Identification

Namedibutyl phthalate
CAS Number84-74-2
EINECS201-557-4
FDA UNII2286E5R2KE
Molecular FormulaC16 H22 O4
Molecular Weight278.34814000
MDL NumberMFCD00009441
Nikkaji NumberJ3.882B
Beilstein1914064
XlogP34.70 (est)

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesFR DOC # 2012-5069
DG SANTE Food Contact Materialsphthalic acid, dibutyl ester
FDA Mainterm (IAUFC)DIBUTYL PHTHALATE
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance colorless clear oily liquid (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.04900 to 1.05300 @ 15.50 °C.
Pounds per Gallon - (est). 8.729 to 8.762
Melting Point -35.00 °C. @ 760.00 mm Hg
Boiling Point 337.00 to 340.00 °C. @ 760.00 mm Hg
Vapor Pressure 1.000000 mmHg @ 147.00 °C.
Vapor Density 9.6 ( Air = 1 )
Flash Point 340.00 °F. TCC ( 171.11 °C. )
logP (o/w) 4.500
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

Organoleptic Properties

Odor Strength low
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 7499 mg/kg
Dermal Toxicityskin-rabbit LD50 > 20 ml/kg
Inhalation Toxicityinhalation-rat LC50 4250 mg/m3

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryindirect food additives: adhesives and components of coatings
Recommendation for dibutyl phthalate usage levels up tonot for fragrance use.
Recommendation for dibutyl phthalate flavor usage levels up tonot for flavor use.

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Potential Uses

fixer insecticide

Natural Occurrence

calamus leaf oil @ 0.40% Data calamus root oil @ 0.15% Data cassie absolute @ 0.02% Data clove oil kohlrabi stem osmanthus absolute @ 0.39% Data rue oil china @ 0.25% Data

Synonyms

o- benzene dicarboxylic acid dibutyl ester ortho- benzene dicarboxylic acid dibutyl ester benzene-o-dicarboxylic acid di-n-butyl ester benzene-o-dicarboxylic acid, di-n-butyl ester benzenedicarboxylic acid dibutyl ester 1,2- benzenedicarboxylic acid dibutyl ester o- benzenedicarboxylic acid dibutyl ester 1,2- benzenedicarboxylic acid, 1,2-dibutyl ester 1,2- benzenedicarboxylic acid, dibutyl ester butyl 2-(butoxycarbonyl)benzoate N- butylphthalate celluflex DPB DBP di-butylphthalate di-n-butyl phthalate di-n-butylorthophthalate dibutyl 1,2-benzene dicarboxylate dibutyl 1,2-benzenedicarboxylate dibutyl benzene-1,2-dicarboxylate dibutyl o-phthalate dibutyl phthalate NF dibutyl-1,2-benzenedicarboxylate dibutyl-o-phthalate dibutylphthatlate elaol ergoplast FDB ergoplast FOB ersoplast FDA genoplast B hatcol DBP hexaplas m/b kodaflex DBP monocizer DBP palatinol C phthalic acid, dibutyl ester polycizer DBP px 104 staflex DBP unimoll DB vestinol C witcizer 300 PubMed: Development of magnetic micro-solid phase extraction for analysis of phthalate esters in packaged food. PubMed: Chemical composition analysis of rose water samples from Iran. PubMed: Intake estimates of phthalate esters for South Delhi population based on exposure media assessment. PubMed: Cumulative risk assessment for plasticizer-contaminated food using the hazard index approach. PubMed: Di-n-butyl phthalate causes estrogenic effects in adult male Murray rainbowfish (Melanotaenia fluviatilis). PubMed: [Preparation of a hydrophilic-lipophilic composite solid phase extraction material and application in food safety inspection]. PubMed: Dermal toxicity elicited by phthalates: evaluation of skin absorption, immunohistology, and functional proteomics. PubMed: Phthalate intake by infants calculated from biomonitoring data. PubMed: Childhood exposure to DEHP, DBP and BBP under existing chemical management systems: a comparative study of sources of childhood exposure in Korea and in Denmark. PubMed: Phthalates in German daycare centers: occurrence in air and dust and the excretion of their metabolites by children (LUPE 3). PubMed: Plasticizer contamination in edible vegetable oil in a U.S. retail market. PubMed: Preliminary toxicological assessment of phthalate esters from drinking water consumed in Portugal. PubMed: Phthalate metabolites in obese individuals undergoing weight loss: Urinary levels and estimation of the phthalates daily intake. PubMed: Pentadecyl ferulate, a potent antioxidant and antiproliferative agent from the halophyte Salicornia herbacea. PubMed: Development of an enzyme-linked immunosorbent assay for dibutyl phthalate in liquor. PubMed: A screen for disruptors of the retinol (vitamin A) signaling pathway. PubMed: Migration of mineral oil, photoinitiators and plasticisers from recycled paperboard into dry foods: a study under controlled conditions. PubMed: Approach to distribution and accumulation of dibutyl phthalate in rats by immunoassay. PubMed: Combined subchronic toxicity of bisphenol A and dibutyl phthalate on male rats. PubMed: Analysis of 16 phthalic acid esters in food simulants from plastic food contact materials by LC-ESI-MS/MS. PubMed: Phthalate analysis by gas chromatography-mass spectrometry: blank problems related to the syringe needle. PubMed: A microflow chemiluminescence sensor for indirect determination of dibutyl phthalate by hydrolyzing based on biological recognition materials. PubMed: Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2). PubMed: Study on the influence of temperature, storage time and packaging type on di-n-butylphthalate and di(2-ethylhexyl)phthalate release into packed meals. PubMed: How dirty are the dirty dozen ingredients in cosmetics? PubMed: Transfer of eight phthalates through the milk chain--a case study. PubMed: Di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) exposure through diet in hospital patients. PubMed: Effect of cooking at home on the levels of eight phthalates in foods. PubMed: Determination of phthalic acid diesters in human milk at low ppb levels. PubMed: Study on chemical composition, anti-inflammatory and anti-microbial activities of extracts from Chinese pear fruit (Pyrus bretschneideri Rehd.). PubMed: Occurrence and profiles of phthalates in foodstuffs from China and their implications for human exposure. PubMed: PVC flooring is related to human uptake of phthalates in infants. PubMed: Socioeconomic factors and phthalate metabolite concentrations among United States women of reproductive age. PubMed: Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach. PubMed: Environmental and food contamination with plasticisers in China. PubMed: Children's exposure to Di(2-ethylhexyl)phthalate and dibutylphthalate plasticizers from school meals. PubMed: Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: a pilot exposure assessment study. PubMed: Phthalates and bisphenols migration in Mexican food cans and plastic food containers. PubMed: Phthalate metabolites in urine from China, and implications for human exposures. PubMed: Identification of LI-F type antibiotics and di-n-butyl phthalate produced by Paenibacillus polymyxa. PubMed: Ginger suppresses phthalate ester-induced airway remodeling. PubMed: A survey of phthalate esters in consumer cosmetic products. PubMed: Determination of phthalate esters in soil by microemulsion electrokinetic chromatography coupled with accelerated solvent extraction. PubMed: [Effect of diisobutyl phthalate on antioxidase activity and DNA damage in mice]. PubMed: Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats. PubMed: Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation. PubMed: Mutagenicity and genotoxicity of tannery effluents used for irrigation at Kanpur, India. PubMed: Assessing exposure to phthalates - the human biomonitoring approach. PubMed: Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity. PubMed: Fast polymer fingerprinting using flowing afterglow atmospheric pressure glow discharge mass spectrometry. PubMed: Development and application of a method for analysis of phthalates in ham sausages by solid-phase extraction and gas chromatography-mass spectrometry. PubMed: Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice. PubMed: Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods. PubMed: Reproductive and developmental toxicity of phthalates. PubMed: Determination of phthalates in diet and bedding for experimental animals using gas chromatography-mass spectrometry. PubMed: Spectroscopic detection of pharmaceutical compounds from an aflatoxigenic strain of Aspergillus parasiticus. PubMed: Analysis and migration of phthalates in infant food packed in recycled paperboard. PubMed: [Determination of trace phthalates in beer by gas chromatography coupled with solid-phase microextraction using a calix[6] arene fiber]. PubMed: Derivation of Biomonitoring Equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP). PubMed: In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig. PubMed: Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces. PubMed: Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. PubMed: Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials. PubMed: Determination of total and free mono-n-butyl phthalate in human urine samples after medication of a di-n-butyl phthalate containing capsule. PubMed: Development and application of an SPME/GC method for the determination of trace phthalates in beer using a calix[6]arene fiber. PubMed: Phthalate exposure through food and consumers' risk perception of chemicals in food. PubMed: Comparison of aromatic and alkyl micelles for the electrokinetic determination of phthalates in virgin olive oil. PubMed: Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development. PubMed: Hazard to the developing male reproductive system from cumulative exposure to phthalate esters--dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate. PubMed: Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. PubMed: Assessing human exposure to phthalic acid and phthalate esters from mineral water stored in polyethylene terephthalate and glass bottles. PubMed: Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor. PubMed: [Matrix solid-phase dispersion and gas chromatography/mass spectrometry for the determination of phthalic acid esters in vegetables]. PubMed: Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells. PubMed: Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus. PubMed: Effects of constructed wetland system on the removal of dibutyl phthalate (DBP). PubMed: Blank problems in trace analysis of diethylhexyl and dibutyl phthalate: investigation of the sources, tips and tricks. PubMed: Oestrogenicity of paper and cardboard extracts used as food containers. PubMed: Comparison and analysis of different approaches for estimating the human exposure to phthalate esters. PubMed: Safe Cosmetics Act aims to lessen cancer risk. PubMed: Determination of phthalate esters from food-contacted materials by on-line microdialysis and liquid chromatography. PubMed: [Analysis of phthalates in plastic food-packaging bags by thin layer chromatography]. PubMed: Toxicity of bisabolangelone from Ostericum koreanum roots to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). PubMed: Analysis of consumer cosmetic products for phthalate esters. PubMed: Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry. PubMed: Human exposure to phthalates via consumer products. PubMed: Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. PubMed: Injector-internal thermal desorption from edible oils. Part 2: chromatographic optimization for the analysis of migrants from food packaging material. PubMed: Functional barriers: properties and evaluation. PubMed: Analysis of the nitrogen mustard mechlorethamine in topical pharmaceutical preparations by high-performance liquid chromatography. PubMed: Determination of partition behavior of organic surrogates between paperboard packaging materials and air. PubMed: Food protective effect of acaricidal components isolated from anise seeds against the stored food mite, Tyrophagus putrescentiae (Schrank). PubMed: Phthalate levels in baby milk powders sold in several countries. PubMed: Acaricidal activity of Paeonia suffruticosa root bark-derived compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae). PubMed: The effects of phthalate esters on the tryptophan-niacin metabolism. PubMed: New methodology for the determination of phthalate esters, bisphenol A, bisphenol A diglycidyl ether, and nonylphenol in commercial whole milk samples. PubMed: Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany). PubMed: [Effects of environmental estrogens on apoptosis induced by estrogen depletion in T47D cells]. PubMed: Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan. PubMed: A simple and reproducible testing method for dialkyl phthalate migration from polyvinyl chloride products into saliva simulant. PubMed: Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home. PubMed: Generation of anticalins with specificity for a nonsymmetric phthalic acid ester. PubMed: [Levels of phthalates and adipates in processed foods and migration of di-isononyl adipate from polyvinyl chloride film into foods]. PubMed: Comparison of embryotoxicity of ESBO and phthalate esters using an in vitro battery system. PubMed: Effects of dibutyl phthalate and monobutyl phthalate on cytotoxicity and differentiation in cultured rat embryonic limb bud cells; protection by antioxidants. PubMed: [Residual chemicals in silicone rubber products for food contact use]. PubMed: A biomarker approach to measuring human dietary exposure to certain phthalate diesters. PubMed: [Residual chemicals in natural rubber products for food contact use]. PubMed: [Contents of eleven phthalates and di(2-ethylhexyl) adipate in retail packed lunches after prohibition of DEHP-containing PVC gloves for cooking purposes]. PubMed: Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy. PubMed: Investigation of migration from paper and board into food--development of methods for rapid testing. PubMed: Phthalates in paper and board packaging and their migration into Tenax and sugar. PubMed: Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment. PubMed: Study of diffusion through LDPE film of Di-n-butyl phthalate. PubMed: Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy. PubMed: Analysis of di-n-butylphthalate biotransformation in cattle by liquid chromatography/ion trap mass spectrometry/mass spectrometry. PubMed: Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. PubMed: UK panics over phthalates in babymilk formulae. PubMed: A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. PubMed: NTP technical report on the toxicity studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice. PubMed: Studies into the transfer and migration of phthalate esters from aluminium foil-paper laminates to butter and margarine. PubMed: Migration of plasticizers from printing inks into foods. PubMed: Non-aqueous size-exclusion chromatography coupled on-line to reversed-phase high-performance liquid chromatography. Interface development and applications to the analysis of low-molecular-weight contaminants and additives in foods. PubMed: Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging. PubMed: Skin-tumour promoting activity of methyl ethyl ketone peroxide--a potent lipid-peroxidizing agent. PubMed: The effect of intestinal esterase inhibition on the in vivo absorption and toxicity of Di-n-butyl phthalate. PubMed: Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. PubMed: Occurrence of dibutyl and di(2-ethylhexyl) phthalate in chicken eggs. PubMed: Absorption and metabolism of three phthalate diesters by the rat small intestine. PubMed: Recent progress in safety evaluation studies on plasticizers and plastics and their controlled use in Japan. PubMed: The retention, distribution, excretion, and metabolism of dibutyl phthalate-7-14 C in the rat.