dibutyl phthalate
phthalic acid, dibutyl ester
Identification
| Name | dibutyl phthalate |
| CAS Number | 84-74-2 |
| EINECS | 201-557-4 |
| FDA UNII | 2286E5R2KE |
| Molecular Formula | C16 H22 O4 |
| Molecular Weight | 278.34814000 |
| MDL Number | MFCD00009441 |
| Nikkaji Number | J3.882B |
| Beilstein | 1914064 |
| XlogP3 | 4.70 (est) |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | FR DOC # 2012-5069 |
| DG SANTE Food Contact Materials | phthalic acid, dibutyl ester |
| FDA Mainterm (IAUFC) | DIBUTYL PHTHALATE |
| FDA Regulation | FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS |
Physical Properties
| Appearance | colorless clear oily liquid (est) |
| Assay | 99.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.04900 to 1.05300 @ 15.50 °C. |
| Pounds per Gallon - (est). | 8.729 to 8.762 |
| Melting Point | -35.00 °C. @ 760.00 mm Hg |
| Boiling Point | 337.00 to 340.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 1.000000 mmHg @ 147.00 °C. |
| Vapor Density | 9.6 ( Air = 1 ) |
| Flash Point | 340.00 °F. TCC ( 171.11 °C. ) |
| logP (o/w) | 4.500 |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | not used anymore |
Organoleptic Properties
| Odor Strength | low |
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | oral-rat LD50 7499 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 20 ml/kg |
| Inhalation Toxicity | inhalation-rat LC50 4250 mg/m3 |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | indirect food additives: adhesives and components of coatings |
| Recommendation for dibutyl phthalate usage levels up to | not for fragrance use. |
| Recommendation for dibutyl phthalate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
o-
benzene dicarboxylic acid dibutyl ester
ortho-
benzene dicarboxylic acid dibutyl ester
benzene-o-dicarboxylic acid di-n-butyl ester
benzene-o-dicarboxylic acid, di-n-butyl ester
benzenedicarboxylic acid dibutyl ester
1,2-
benzenedicarboxylic acid dibutyl ester
o-
benzenedicarboxylic acid dibutyl ester
1,2-
benzenedicarboxylic acid, 1,2-dibutyl ester
1,2-
benzenedicarboxylic acid, dibutyl ester
butyl 2-(butoxycarbonyl)benzoate
N-
butylphthalate
celluflex DPB
DBP
di-butylphthalate
di-n-butyl phthalate
di-n-butylorthophthalate
dibutyl 1,2-benzene dicarboxylate
dibutyl 1,2-benzenedicarboxylate
dibutyl benzene-1,2-dicarboxylate
dibutyl o-phthalate
dibutyl phthalate NF
dibutyl-1,2-benzenedicarboxylate
dibutyl-o-phthalate
dibutylphthatlate
elaol
ergoplast FDB
ergoplast FOB
ersoplast FDA
genoplast B
hatcol DBP
hexaplas m/b
kodaflex DBP
monocizer DBP
palatinol C
phthalic acid, dibutyl ester
polycizer DBP
px 104
staflex DBP
unimoll DB
vestinol C
witcizer 300
PubMed:
Development of magnetic micro-solid phase extraction for analysis of phthalate esters in packaged food.
PubMed:
Chemical composition analysis of rose water samples from Iran.
PubMed:
Intake estimates of phthalate esters for South Delhi population based on exposure media assessment.
PubMed:
Cumulative risk assessment for plasticizer-contaminated food using the hazard index approach.
PubMed:
Di-n-butyl phthalate causes estrogenic effects in adult male Murray rainbowfish (Melanotaenia fluviatilis).
PubMed:
[Preparation of a hydrophilic-lipophilic composite solid phase extraction material and application in food safety inspection].
PubMed:
Dermal toxicity elicited by phthalates: evaluation of skin absorption, immunohistology, and functional proteomics.
PubMed:
Phthalate intake by infants calculated from biomonitoring data.
PubMed:
Childhood exposure to DEHP, DBP and BBP under existing chemical management systems: a comparative study of sources of childhood exposure in Korea and in Denmark.
PubMed:
Phthalates in German daycare centers: occurrence in air and dust and the excretion of their metabolites by children (LUPE 3).
PubMed:
Plasticizer contamination in edible vegetable oil in a U.S. retail market.
PubMed:
Preliminary toxicological assessment of phthalate esters from drinking water consumed in Portugal.
PubMed:
Phthalate metabolites in obese individuals undergoing weight loss: Urinary levels and estimation of the phthalates daily intake.
PubMed:
Pentadecyl ferulate, a potent antioxidant and antiproliferative agent from the halophyte Salicornia herbacea.
PubMed:
Development of an enzyme-linked immunosorbent assay for dibutyl phthalate in liquor.
PubMed:
A screen for disruptors of the retinol (vitamin A) signaling pathway.
PubMed:
Migration of mineral oil, photoinitiators and plasticisers from recycled paperboard into dry foods: a study under controlled conditions.
PubMed:
Approach to distribution and accumulation of dibutyl phthalate in rats by immunoassay.
PubMed:
Combined subchronic toxicity of bisphenol A and dibutyl phthalate on male rats.
PubMed:
Analysis of 16 phthalic acid esters in food simulants from plastic food contact materials by LC-ESI-MS/MS.
PubMed:
Phthalate analysis by gas chromatography-mass spectrometry: blank problems related to the syringe needle.
PubMed:
A microflow chemiluminescence sensor for indirect determination of dibutyl phthalate by hydrolyzing based on biological recognition materials.
PubMed:
Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2).
PubMed:
Study on the influence of temperature, storage time and packaging type on di-n-butylphthalate and di(2-ethylhexyl)phthalate release into packed meals.
PubMed:
How dirty are the dirty dozen ingredients in cosmetics?
PubMed:
Transfer of eight phthalates through the milk chain--a case study.
PubMed:
Di(2-ethylhexyl)phthalate (DEHP) and di-n-butylphthalate (DBP) exposure through diet in hospital patients.
PubMed:
Effect of cooking at home on the levels of eight phthalates in foods.
PubMed:
Determination of phthalic acid diesters in human milk at low ppb levels.
PubMed:
Study on chemical composition, anti-inflammatory and anti-microbial activities of extracts from Chinese pear fruit (Pyrus bretschneideri Rehd.).
PubMed:
Occurrence and profiles of phthalates in foodstuffs from China and their implications for human exposure.
PubMed:
PVC flooring is related to human uptake of phthalates in infants.
PubMed:
Socioeconomic factors and phthalate metabolite concentrations among United States women of reproductive age.
PubMed:
Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach.
PubMed:
Environmental and food contamination with plasticisers in China.
PubMed:
Children's exposure to Di(2-ethylhexyl)phthalate and dibutylphthalate plasticizers from school meals.
PubMed:
Exposure to phthalates among premenstrual girls from rural and urban Gharbiah, Egypt: a pilot exposure assessment study.
PubMed:
Phthalates and bisphenols migration in Mexican food cans and plastic food containers.
PubMed:
Phthalate metabolites in urine from China, and implications for human exposures.
PubMed:
Identification of LI-F type antibiotics and di-n-butyl phthalate produced by Paenibacillus polymyxa.
PubMed:
Ginger suppresses phthalate ester-induced airway remodeling.
PubMed:
A survey of phthalate esters in consumer cosmetic products.
PubMed:
Determination of phthalate esters in soil by microemulsion electrokinetic chromatography coupled with accelerated solvent extraction.
PubMed:
[Effect of diisobutyl phthalate on antioxidase activity and DNA damage in mice].
PubMed:
Effects of in utero exposure to DI(n-Butyl) phthalate on development of male reproductive tracts in Sprague-Dawley rats.
PubMed:
Phthalates and food-contact materials: enforcing the 2008 European Union plastics legislation.
PubMed:
Mutagenicity and genotoxicity of tannery effluents used for irrigation at Kanpur, India.
PubMed:
Assessing exposure to phthalates - the human biomonitoring approach.
PubMed:
Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity.
PubMed:
Fast polymer fingerprinting using flowing afterglow atmospheric pressure glow discharge mass spectrometry.
PubMed:
Development and application of a method for analysis of phthalates in ham sausages by solid-phase extraction and gas chromatography-mass spectrometry.
PubMed:
Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice.
PubMed:
Development of a gas chromatographic/mass spectrometric method for determination of phthalates in oily foods.
PubMed:
Reproductive and developmental toxicity of phthalates.
PubMed:
Determination of phthalates in diet and bedding for experimental animals using gas chromatography-mass spectrometry.
PubMed:
Spectroscopic detection of pharmaceutical compounds from an aflatoxigenic strain of Aspergillus parasiticus.
PubMed:
Analysis and migration of phthalates in infant food packed in recycled paperboard.
PubMed:
[Determination of trace phthalates in beer by gas chromatography coupled with solid-phase microextraction using a calix[6] arene fiber].
PubMed:
Derivation of Biomonitoring Equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP).
PubMed:
In vivo and in vitro skin absorption of lipophilic compounds, dibutyl phthalate, farnesol and geraniol in the hairless guinea pig.
PubMed:
Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces.
PubMed:
Comparison of in vitro hormone activities of selected phthalates using reporter gene assays.
PubMed:
Recent European Food Safety Authority toxicological evaluations of major phthalates used in food contact materials.
PubMed:
Determination of total and free mono-n-butyl phthalate in human urine samples after medication of a di-n-butyl phthalate containing capsule.
PubMed:
Development and application of an SPME/GC method for the determination of trace phthalates in beer using a calix[6]arene fiber.
PubMed:
Phthalate exposure through food and consumers' risk perception of chemicals in food.
PubMed:
Comparison of aromatic and alkyl micelles for the electrokinetic determination of phthalates in virgin olive oil.
PubMed:
Cumulative effects of in utero administration of mixtures of "antiandrogens" on male rat reproductive development.
PubMed:
Hazard to the developing male reproductive system from cumulative exposure to phthalate esters--dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate.
PubMed:
Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats.
PubMed:
Assessing human exposure to phthalic acid and phthalate esters from mineral water stored in polyethylene terephthalate and glass bottles.
PubMed:
Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor.
PubMed:
[Matrix solid-phase dispersion and gas chromatography/mass spectrometry for the determination of phthalic acid esters in vegetables].
PubMed:
Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells.
PubMed:
Toxicity of atractylon and atractylenolide III Identified in Atractylodes ovata rhizome to Dermatophagoides farinae and Dermatophagoides pteronyssinus.
PubMed:
Effects of constructed wetland system on the removal of dibutyl phthalate (DBP).
PubMed:
Blank problems in trace analysis of diethylhexyl and dibutyl phthalate: investigation of the sources, tips and tricks.
PubMed:
Oestrogenicity of paper and cardboard extracts used as food containers.
PubMed:
Comparison and analysis of different approaches for estimating the human exposure to phthalate esters.
PubMed:
Safe Cosmetics Act aims to lessen cancer risk.
PubMed:
Determination of phthalate esters from food-contacted materials by on-line microdialysis and liquid chromatography.
PubMed:
[Analysis of phthalates in plastic food-packaging bags by thin layer chromatography].
PubMed:
Toxicity of bisabolangelone from Ostericum koreanum roots to Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae).
PubMed:
Analysis of consumer cosmetic products for phthalate esters.
PubMed:
Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry.
PubMed:
Human exposure to phthalates via consumer products.
PubMed:
Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis.
PubMed:
Injector-internal thermal desorption from edible oils. Part 2: chromatographic optimization for the analysis of migrants from food packaging material.
PubMed:
Functional barriers: properties and evaluation.
PubMed:
Analysis of the nitrogen mustard mechlorethamine in topical pharmaceutical preparations by high-performance liquid chromatography.
PubMed:
Determination of partition behavior of organic surrogates between paperboard packaging materials and air.
PubMed:
Food protective effect of acaricidal components isolated from anise seeds against the stored food mite, Tyrophagus putrescentiae (Schrank).
PubMed:
Phthalate levels in baby milk powders sold in several countries.
PubMed:
Acaricidal activity of Paeonia suffruticosa root bark-derived compounds against Dermatophagoides farinae and Dermatophagoides pteronyssinus (Acari: Pyroglyphidae).
PubMed:
The effects of phthalate esters on the tryptophan-niacin metabolism.
PubMed:
New methodology for the determination of phthalate esters, bisphenol A, bisphenol A diglycidyl ether, and nonylphenol in commercial whole milk samples.
PubMed:
Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany).
PubMed:
[Effects of environmental estrogens on apoptosis induced by estrogen depletion in T47D cells].
PubMed:
Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan.
PubMed:
A simple and reproducible testing method for dialkyl phthalate migration from polyvinyl chloride products into saliva simulant.
PubMed:
Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home.
PubMed:
Generation of anticalins with specificity for a nonsymmetric phthalic acid ester.
PubMed:
[Levels of phthalates and adipates in processed foods and migration of di-isononyl adipate from polyvinyl chloride film into foods].
PubMed:
Comparison of embryotoxicity of ESBO and phthalate esters using an in vitro battery system.
PubMed:
Effects of dibutyl phthalate and monobutyl phthalate on cytotoxicity and differentiation in cultured rat embryonic limb bud cells; protection by antioxidants.
PubMed:
[Residual chemicals in silicone rubber products for food contact use].
PubMed:
A biomarker approach to measuring human dietary exposure to certain phthalate diesters.
PubMed:
[Residual chemicals in natural rubber products for food contact use].
PubMed:
[Contents of eleven phthalates and di(2-ethylhexyl) adipate in retail packed lunches after prohibition of DEHP-containing PVC gloves for cooking purposes].
PubMed:
Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy.
PubMed:
Investigation of migration from paper and board into food--development of methods for rapid testing.
PubMed:
Phthalates in paper and board packaging and their migration into Tenax and sugar.
PubMed:
Effects of di-n-butyl phthalate (DBP) on male reproductive development in the rat: implications for human risk assessment.
PubMed:
Study of diffusion through LDPE film of Di-n-butyl phthalate.
PubMed:
Critical period for adverse effects on development of reproductive system in male offspring of rats given di-n-butyl phthalate during late pregnancy.
PubMed:
Analysis of di-n-butylphthalate biotransformation in cattle by liquid chromatography/ion trap mass spectrometry/mass spectrometry.
PubMed:
Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist.
PubMed:
UK panics over phthalates in babymilk formulae.
PubMed:
A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic.
PubMed:
NTP technical report on the toxicity studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice.
PubMed:
Studies into the transfer and migration of phthalate esters from aluminium foil-paper laminates to butter and margarine.
PubMed:
Migration of plasticizers from printing inks into foods.
PubMed:
Non-aqueous size-exclusion chromatography coupled on-line to reversed-phase high-performance liquid chromatography. Interface development and applications to the analysis of low-molecular-weight contaminants and additives in foods.
PubMed:
Migration from plasticized films into foods. 3. Migration of phthalate, sebacate, citrate and phosphate esters from films used for retail food packaging.
PubMed:
Skin-tumour promoting activity of methyl ethyl ketone peroxide--a potent lipid-peroxidizing agent.
PubMed:
The effect of intestinal esterase inhibition on the in vivo absorption and toxicity of Di-n-butyl phthalate.
PubMed:
Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice.
PubMed:
Occurrence of dibutyl and di(2-ethylhexyl) phthalate in chicken eggs.
PubMed:
Absorption and metabolism of three phthalate diesters by the rat small intestine.
PubMed:
Recent progress in safety evaluation studies on plasticizers and plastics and their controlled use in Japan.
PubMed:
The retention, distribution, excretion, and metabolism of dibutyl phthalate-7-14 C in the rat.