Identification

Namemethyl carbitol
IUPAC2-(2-methoxyethoxy)ethanol
CAS Number111-77-3
EINECS203-906-6
FDA UNII465DDJ8G8K
Molecular FormulaC5 H12 O3
Molecular Weight120.14824000
MDL NumberMFCD00002871
Nikkaji NumberJ5.114D
Beilstein1697812
XlogP3-0.90 (est)

Regulatory

FDA Mainterm (IAUFC)111-77-3 ; DIETHYLENE GLYCOL MONOMETHYL ETHER
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance colorless clear liquid (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.02000 to 1.02400 @ 20.00 °C.
Pounds per Gallon - (est). 8.497 to 8.531
Refractive Index 1.42400 to 1.42700 @ 20.00 °C.
Melting Point -70.00 °C. @ 760.00 mm Hg
Boiling Point 191.00 to 198.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.118000 mmHg @ 25.00 °C. (est)
Vapor Density 4.14 ( Air = 1 )
Flash Point 191.00 °F. TCC ( 88.00 °C. )
logP (o/w) -1.156 (est)
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

Organoleptic Properties

Odor Strength low
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 4 ml/kg
Dermal Toxicityskin-rabbit LD50 2500 ul/kg
Inhalation Toxicityinhalation-rat LC > 2000 mg/m3/1H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysolvents/deluents for cosmetic and fragrance agents
Recommendation for methyl carbitol usage levels up tonot for fragrance use.
Recommendation for methyl carbitol flavor usage levels up tonot for flavor use.

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Potential Uses

solvents

Natural Occurrence

not found in nature

Synonyms

diethylene glycol monomethyl ether diglycol monomethyl ether DM solvent ethanol, 2-(2-methoxyethoxy)- glycol ether DM MECB methoxydiglycol 2-(2- methoxyethoxy) ethanol 2-(2- methoxyethoxy)-ethanol 2-(2- methoxyethoxy)ethan-1-ol 2-(2- methoxyethoxy)ethanol methyl carbitol methyldiglycol PubMed: A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: Synthesis and characterization of physical and toxicological properties. PubMed: Oxidative metalation as a route to size-mismatched macrocyclic complexes: osmium corroles. PubMed: The effect of amphiphilic polymers on the association, morphology and photophysical properties of hypocrellin coordination polymer/fullerene assemblies. PubMed: Sensitivity improvement in hydrophilic interaction chromatography negative mode electrospray ionization mass spectrometry using 2-(2-methoxyethoxy)ethanol as a post-column modifier for non-targeted metabolomics. PubMed: Os(II) phosphors with near-infrared emission induced by ligand-to-ligand charge transfer transition. PubMed: Peptide hydrogels assembled from nonionic alkyl-polypeptide amphiphiles prepared by ring-opening polymerization. PubMed: Lanthanum(III) catalysts for highly efficient and chemoselective transesterification. PubMed: Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group. PubMed: Detection of DNA damage in workers exposed to JP-8 jet fuel. PubMed: (2-methoxyethoxy)acetic acid: a urinary biomarker of exposure for jet fuel JP-8. PubMed: Lanthanum(III) isopropoxide catalyzed chemoselective transesterification of dimethyl carbonate and methyl carbamates. PubMed: Ligand-assisted rate acceleration in lanthanum(III) isopropoxide catalyzed transesterification of carboxylic esters. PubMed: Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes. PubMed: Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis. PubMed: Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. PubMed: Corrosion of aluminum alloy 2024 by microorganisms isolated from aircraft fuel tanks. PubMed: Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine. PubMed: Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids. PubMed: A Test Procedure for the Determination of (2-Methoxyethoxy)acetic Acid in Urine from Jet Fuel-Exposed Mice. PubMed: Mechanism of the transition between lamellar and gyroid phases formed by a diblock copolymer in aqueous solution. PubMed: A cohesion/tension mechanism explains the gating of water channels (aquaporins) in Chara internodes by high concentration. PubMed: Procedure for the quantification of the biomarker (2-methoxyethoxy)acetic acid in human urine samples. PubMed: Efficacy of two 65% permethrin spot-on formulations against induced infestations of Ctenocephalides felis (Insecta: Siphonaptera) and Amblyomma americanum (Acari: Ixodidae) on beagles. PubMed: Efficacy of two 65 % permethrin spot-on formulations against canine infestations of Ctenocephalides felis and Rhipicephalus sanguineus. PubMed: Maternal exposure to diethylene glycol monomethyl ether: a possible role in the etiology of retrocaval ureter. PubMed: In vitro toxicities of experimental jet fuel system ice-inhibiting agents. PubMed: Identification of rat urinary and biliary metabolites of esonarimod, a novel antirheumatic drug, using liquid chromatography/electrospray ionization tandem mass spectrometry with postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier. PubMed: Assessment of skin absorption and penetration of JP-8 jet fuel and its components. PubMed: Utility of postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier, for metabolite screening with liquid chromatography and negative ion electrospray ionization mass spectrometry. PubMed: To what extent are biomonitoring data available in chemical risk assessment? PubMed: Effects of diethylene glycol monomethyl ether on pregnancy and postnatal development in rats. PubMed: Comparative metabolism of bis(2-methoxyethyl)ether in isolated rat hepatocytes and in the intact rat: effects of ethanol on in vitro metabolism. PubMed: The effect of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether on hepatic gamma-glutamyl transpeptidase. PubMed: First practical colorimetric assay of lithium in serum. PubMed: Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats. PubMed: Induction of r-GTP by ethylene glycol monomethyl ether. PubMed: Bis(2-methoxyethyl) ether: metabolism and embryonic disposition of a developmental toxicant in the pregnant CD-1 mouse. PubMed: A numerical procedure for choosing effective, low toxicity plasticizers for glycol methacrylate embedding. PubMed: Effect of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether on hepatic metabolizing enzymes. PubMed: Acute oral toxicity of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether. PubMed: Aspects of biological monitoring of exposure to glycol ethers. PubMed: Metabolism of bis(2-methoxyethyl) ether in the adult male rat: evaluation of the principal metabolite as a testicular toxicant. PubMed: Evaluation of 60 chemicals in a preliminary developmental toxicity test. PubMed: Teratologic evaluation of dermally applied diethylene glycol monomethyl ether in rabbits. PubMed: Developmental toxicity of diethylene glycol monomethyl ether (diEGME). PubMed: A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig. PubMed: Diethylene glycol monomethyl ether 13-week vapor inhalation toxicity study in rats. PubMed: Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan. PubMed: Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment. PubMed: Absorption of some glycol ethers through human skin in vitro. PubMed: Biocidal properties of anti-icing additives for aircraft fuels.