methyl carbitol
ethanol, 2-(2-methoxyethoxy)-
Identification
| Name | methyl carbitol |
| IUPAC | 2-(2-methoxyethoxy)ethanol |
| CAS Number | 111-77-3 |
| EINECS | 203-906-6 |
| FDA UNII | 465DDJ8G8K |
| Molecular Formula | C5 H12 O3 |
| Molecular Weight | 120.14824000 |
| MDL Number | MFCD00002871 |
| Nikkaji Number | J5.114D |
| Beilstein | 1697812 |
| XlogP3 | -0.90 (est) |
Regulatory
| FDA Mainterm (IAUFC) | 111-77-3 ; DIETHYLENE GLYCOL MONOMETHYL ETHER |
| FDA Regulation | FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 97.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.02000 to 1.02400 @ 20.00 °C. |
| Pounds per Gallon - (est). | 8.497 to 8.531 |
| Refractive Index | 1.42400 to 1.42700 @ 20.00 °C. |
| Melting Point | -70.00 °C. @ 760.00 mm Hg |
| Boiling Point | 191.00 to 198.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.118000 mmHg @ 25.00 °C. (est) |
| Vapor Density | 4.14 ( Air = 1 ) |
| Flash Point | 191.00 °F. TCC ( 88.00 °C. ) |
| logP (o/w) | -1.156 (est) |
| Soluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | not used anymore |
Organoleptic Properties
| Odor Strength | low |
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | oral-rat LD50 4 ml/kg |
| Dermal Toxicity | skin-rabbit LD50 2500 ul/kg |
| Inhalation Toxicity | inhalation-rat LC > 2000 mg/m3/1H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | solvents/deluents for cosmetic and fragrance agents |
| Recommendation for methyl carbitol usage levels up to | not for fragrance use. |
| Recommendation for methyl carbitol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
diethylene glycol monomethyl ether
diglycol monomethyl ether
DM solvent
ethanol, 2-(2-methoxyethoxy)-
glycol ether DM
MECB
methoxydiglycol
2-(2-
methoxyethoxy) ethanol
2-(2-
methoxyethoxy)-ethanol
2-(2-
methoxyethoxy)ethan-1-ol
2-(2-
methoxyethoxy)ethanol
methyl carbitol
methyldiglycol
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A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: Synthesis and characterization of physical and toxicological properties.
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Oxidative metalation as a route to size-mismatched macrocyclic complexes: osmium corroles.
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The effect of amphiphilic polymers on the association, morphology and photophysical properties of hypocrellin coordination polymer/fullerene assemblies.
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Sensitivity improvement in hydrophilic interaction chromatography negative mode electrospray ionization mass spectrometry using 2-(2-methoxyethoxy)ethanol as a post-column modifier for non-targeted metabolomics.
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Os(II) phosphors with near-infrared emission induced by ligand-to-ligand charge transfer transition.
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Peptide hydrogels assembled from nonionic alkyl-polypeptide amphiphiles prepared by ring-opening polymerization.
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Lanthanum(III) catalysts for highly efficient and chemoselective transesterification.
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Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group.
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Detection of DNA damage in workers exposed to JP-8 jet fuel.
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(2-methoxyethoxy)acetic acid: a urinary biomarker of exposure for jet fuel JP-8.
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Lanthanum(III) isopropoxide catalyzed chemoselective transesterification of dimethyl carbonate and methyl carbamates.
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Ligand-assisted rate acceleration in lanthanum(III) isopropoxide catalyzed transesterification of carboxylic esters.
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Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes.
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Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis.
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Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether.
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Corrosion of aluminum alloy 2024 by microorganisms isolated from aircraft fuel tanks.
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Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine.
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Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids.
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A Test Procedure for the Determination of (2-Methoxyethoxy)acetic Acid in Urine from Jet Fuel-Exposed Mice.
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Mechanism of the transition between lamellar and gyroid phases formed by a diblock copolymer in aqueous solution.
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A cohesion/tension mechanism explains the gating of water channels (aquaporins) in Chara internodes by high concentration.
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Procedure for the quantification of the biomarker (2-methoxyethoxy)acetic acid in human urine samples.
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Efficacy of two 65% permethrin spot-on formulations against induced infestations of Ctenocephalides felis (Insecta: Siphonaptera) and Amblyomma americanum (Acari: Ixodidae) on beagles.
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Efficacy of two 65 % permethrin spot-on formulations against canine infestations of Ctenocephalides felis and Rhipicephalus sanguineus.
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Maternal exposure to diethylene glycol monomethyl ether: a possible role in the etiology of retrocaval ureter.
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In vitro toxicities of experimental jet fuel system ice-inhibiting agents.
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Identification of rat urinary and biliary metabolites of esonarimod, a novel antirheumatic drug, using liquid chromatography/electrospray ionization tandem mass spectrometry with postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier.
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Assessment of skin absorption and penetration of JP-8 jet fuel and its components.
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Utility of postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier, for metabolite screening with liquid chromatography and negative ion electrospray ionization mass spectrometry.
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To what extent are biomonitoring data available in chemical risk assessment?
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Effects of diethylene glycol monomethyl ether on pregnancy and postnatal development in rats.
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Comparative metabolism of bis(2-methoxyethyl)ether in isolated rat hepatocytes and in the intact rat: effects of ethanol on in vitro metabolism.
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The effect of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether on hepatic gamma-glutamyl transpeptidase.
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First practical colorimetric assay of lithium in serum.
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Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats.
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Induction of r-GTP by ethylene glycol monomethyl ether.
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Bis(2-methoxyethyl) ether: metabolism and embryonic disposition of a developmental toxicant in the pregnant CD-1 mouse.
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A numerical procedure for choosing effective, low toxicity plasticizers for glycol methacrylate embedding.
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Effect of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether on hepatic metabolizing enzymes.
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Acute oral toxicity of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether.
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Aspects of biological monitoring of exposure to glycol ethers.
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Metabolism of bis(2-methoxyethyl) ether in the adult male rat: evaluation of the principal metabolite as a testicular toxicant.
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Evaluation of 60 chemicals in a preliminary developmental toxicity test.
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Teratologic evaluation of dermally applied diethylene glycol monomethyl ether in rabbits.
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Developmental toxicity of diethylene glycol monomethyl ether (diEGME).
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A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig.
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Diethylene glycol monomethyl ether 13-week vapor inhalation toxicity study in rats.
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Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan.
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Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment.
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Absorption of some glycol ethers through human skin in vitro.
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Biocidal properties of anti-icing additives for aircraft fuels.