myricanone
tricyclo[12.3.1.12,6]nonadeca-1(18),2,4,6(19),14,16-hexaen-9-one, 3,15-dihydroxy-16,17-dimethoxy-
Identification
| Name | myricanone |
| CAS Number | 32492-74-3 |
| FDA UNII | Search |
| Molecular Formula | C21 H24 O5 |
| Molecular Weight | 356.41828000 |
| Nikkaji Number | J19.021G |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 583.69 °C. @ 760.00 mm Hg (est) |
| Flash Point | 404.00 °F. TCC ( 206.70 °C. ) (est) |
| logP (o/w) | 3.790 (est) |
| Soluble in | water, 1.484 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for myricanone usage levels up to | not for fragrance use. |
| Recommendation for myricanone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
3,15-
dihydroxy-16,17-dimethoxytricyclo(12.3.1.12,6)nonadeca-1(18),2,4,6(19),14,16-hexaen-9-one
3,15-
dihydroxy-16,17-dimethoxytricyclo[12.3.1.12,6]nonadeca-1(18),2(19),3,5,14,16-hexaen-9-one
tricyclo(12.3.1.12,6)nonadeca-1(18),2,4,6(19),14,16-hexaen-9-one, 3,15-dihydroxy-16,17-dimethoxy-
tricyclo[12.3.1.12,6]nonadeca-1(18),2,4,6(19),14,16-hexaen-9-one, 3,15-dihydroxy-16,17-dimethoxy-
PubMed:
In vitro Anticancer Activity of Myricanone in Human Lung Adenocarcinoma A549 Cells.
PubMed:
Biological evaluation of secondary metabolites from the roots of Myrica adenophora.
PubMed:
Diarylheptanoid-myricanone isolated from ethanolic extract of Myrica cerifera shows anticancer effects on HeLa and PC3 cell lines: signalling pathway and drug-DNA interaction.
PubMed:
Anticancer potential of myricanone, a major bioactive component of Myrica cerifera: novel signaling cascade for accomplishing apoptosis.
PubMed:
Diarylheptanoid sulfates and related compounds from Myrica rubra bark.
PubMed:
Three new cyclic diarylheptanoids and other phenolic compounds from the bark of Myrica rubra and their melanogenesis inhibitory and radical scavenging activities.
PubMed:
Inhibitors of nitric oxide production from the bark of Myrica rubra: structures of new biphenyl type diarylheptanoid glycosides and taraxerane type triterpene.
PubMed:
Chemopreventive potential of cyclic diarylheptanoids.
PubMed:
Bioactive constituents of Chinese natural medicines. VII. Inhibitors of degranulation in RBL-2H3 cells and absolute stereostructures of three new diarylheptanoid glycosides from the bark of Myrica rubra.
PubMed:
Anti-androgenic activity of Myricae Cortex--isolation of active constituents from bark of Myrica rubra.
PubMed:
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
PubMed:
[Constituents of Acer nikoense and Myrica rubra. On diarylheptanoids].
PubMed:
[Diarylheptanoids in the bark of Myrica rubra Sieb. et Zucc].