Identification

Namebenzyl salicylate
IUPACbenzyl 2-hydroxybenzoate
CAS Number118-58-1
EINECS204-262-9
FDA UNIIWAO5MNK9TU
Molecular FormulaC14 H12 O3
Molecular Weight228.24724000
MDL NumberMFCD00020034
Nikkaji NumberJ36.457F
Beilstein2115365
CoE Number436
XlogP33.20 (est)

Regulatory

JECFA Food Flavoring904 benzyl salicylate
DG SANTE Food Flavourings09.752 benzyl salicylate
FEMA Number2151
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)118-58-1 ; BENZYL SALICYLATE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless to pale yellow clear oily liquid to solid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed Yes
Specific Gravity 1.17300 to 1.18100 @ 25.00 °C., 1.17400 to 1.18200 @ 20.00 °C.
Pounds per Gallon - (est). 9.761 to 9.827
Pounds per Gallon - est. 9.780 to 9.847
Refractive Index 1.57900 to 1.58300 @ 20.00 °C.
Melting Point 22.00 to 25.00 °C. @ 760.00 mm Hg
Boiling Point 208.00 °C. @ 26.00 mm Hg, 168.00 to 170.00 °C. @ 5.00 mm Hg
Congealing Point 23.00 °C.
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.000170 mmHg @ 25.00 °C. (est)
Flash Point 356.00 °F. TCC ( 180.00 °C. )
logP (o/w) 4.209 (est)
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in deluent for candle fragrances
Insoluble in water
Stability acid cleaner
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength low
Substantivity 384 hour(s) at 100.00 %
Odor Description
at 100.00 %.
Floral, Balsamic, Sweet
weak, but very good fixative, sweet-floral, spicy, balsamic, slightly phenolic, azalea, gillyflower, ylang ylang, narcissus
sweet, balsamic, slightly curative
fresh sweet balsam clean herbal oily sweet soft-narcotic frangipanni balsamic aromatic
Sweet-floral, spicy, balsamic, slightly phenolic, typical salicylate
Odor sample from Berje Inc.
Taste Description
sweet balsamic orchid herbal soapy
sweet, balsamic, slightly medical
balsamic, sweet

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience30 % solution: no irritation or sensitization.
Oral/Parenteral Toxicitygavage-rat LD50 [sex: M] 2227 mg/kg
Dermal Toxicityskin-rabbit LD50 14150 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
IFRA Critical EffectDermal sensitization
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%)Category 1: Products applied to the lips
NotesIFRA FLAVOR REQUIREMENTS:
use level in formulae for use in cosmetics15.7900 %
Dermal Systemic Exposure in Cosmetic Products0.40 mg/kg/day (IFRA, 2002)
Maximised Survey-derived Daily Intakes (MSDI-EU)26.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)29.00 (μg/capita/day)
baked goods0.01000
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Advanced Biotech. Inc.

Inspired by Nature

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Augustus Oils Ltd

The Premier Supplier

Augustus Oils Ltd, in harmony with nature - to present it at its best...

View All Website +44 (0)1420 590555 essentials@augustus-oils.ltd.uk

Beijing Lys Chemicals Co, LTD.

From Grams to Tons

Fine chemical high-tech company which contains R&D, production, and sales.

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Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

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BOC Sciences

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ECSA Chemicals

Human Chemistry

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View All Website +41 91 695 88 00 marketing@ecsa.ch

Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

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Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

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Global Essence Inc.

Preferred Partner

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Indukern, S.A. F&F Ingredients Division

Commitment to quality

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Lluch Essence S.L.

A family company dedicated to sales and distribution

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M&U International LLC

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Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

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OQEMA

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Pell Wall Perfumes

Hand-made fragrances

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Penta International Corporation

Chemistry innovation

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PerfumersWorld Ltd.

feeeel... the smell!

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Prodasynth

PRODUCTEUR PAR ESSENCE

Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.

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Robertet, Inc.

HOME OF NATURE, SEED TO SCENT

HOME OF NATURE – natural ingredients from the source.

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Sigma-Aldrich

Complete Supply Chain

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View All Website 800-244-1173 ff@sial.com

SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

View All Website +44 (0) 1284 704076 info@srsaromatics.co.uk

Sunaux International

Buy With Confidence

We have industry leading processes and procedures to ensure nothing but the most reliable product.

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Taytonn ASCC Pte Ltd

Supplying Asia Pacific

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TCI AMERICA

Moving Your Chemistry Forward

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The Good Scents Company

Fragrance Creators

For your fragrance creations.

View All Website 414-764-2659 goodscnt@thegoodscentscompany.com

The John D. Walsh Company, Inc

Suppliers Since 1942

Supplying the fragrance and flavor industry with high quality products.

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The Lermond Company

Your Sourcing Resource

The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.

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R C Treatt and Co Ltd

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Ernesto Ventós S.A.

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Vigon International

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Zanos Ltd.

Distributor of Speciality Chemicals and Natural Ingredients

Sourcing and supplying quality aroma chemicals and prestige natural ingredients for the flavour and fragrance industry.

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Potential Uses

FR acacia aimant FR aldehydic FR amber FR ambergris FR ambrene amour-amour anais anais FR apple FR apple green apple FR apple red apple FR apricot arpege FR baby powder FR balsam FR banana bellodgia FR blue grass FR blue mist FR bluebell FR blueberry FR botanical FR bouquet FR bubble gum cabochard FR carnation FR cassia FR castoreum FR cedar chanel #5 charlie FR cherry FR cherry blossom chloe cinq fleurs forvil FR citrus clean FR clean linen FR clover FR coconut FR coconut tropical coconut FR currant FR elder berry FR elder flower estee FR evergreen FR fetes fidji fleurs de rocailles FR floral FR flower shop FR fresh and clean FR fresh outdoors FR gardenia FR gooseberry FR grape FR grapefruit FR green leaf FR hay new mown hay FR heliotrope FR herbal FR hyacinth FR incense FR jasmin je reviens FR jonquil joy l'air du temps FR leather russian leather FR lemon FR lilac FR lily FR lily of the valley FR lime FR linden flower FR lotus FR magnolia FR mint FR musk my sin FR new car norell FR ophira FR orange FR oriental paris FR peach FR pear FL/FR pennyroyal FR pineapple FR plum FR popcorn FR potpourri presence FR rain FR raspberry FR rose tea rose FR sandalwood FR sea breeze FR spice FR spring rain FR strawberry FR sweet grass FR tuberose FR vanilla FR violet FR wallflower FR wisteria FR woodruff FR ylang ylang

Natural Occurrence

ayou wood oil @ 1.60% Data cananga odorata oil java @ 0.03% Data carnation carnation absolute @ 3.90% Data clove bud clove fruit jasmin PbMd PMC narcissus absolute @ 0.17% Data primula auricula ylang ylang oil @ 1.37% Data ylang ylang oil CO2 extract @ 3.66% Data ylang ylang oil I (cananga odorata hook. f. and thomas.) @ 2.63% Data ylang ylang oil II (cananga odorata hook. f. and thomas.) @ 3.05% Data ylang ylang oil III @ 2.81% Data

Synonyms

benzoic acid, 2-hydroxy-, phenylmethyl ester benzyl 2-hydroxybenzoate benzyl o-hydroxybenzoate benzyl ortho-hydroxybenzoate benzyl salicylate FCC benzyl salicylate natural benzylsalicylate 2- hydroxybenzoic acid phenyl methyl ester 2- hydroxybenzoic acid phenylmethyl ester 2- hydroxybenzoic acid, phenylmethyl ester phenyl methyl 2-hydroxybenzoate phenylmethyl 2-hydroxybenzoate salicyclic acid benzyl ester salicylic acid benzyl ester salicylic acid, benzyl ester salicylsaeurebenzylester PubMed: Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. PubMed: Pigmented contact dermatitis secondary to benzyl salicylate. PubMed: Propolis specimens from different locations of central Italy: chemical profiling and gas chromatography-mass spectrometry (GC-MS) quantitative analysis of the allergenic esters benzyl cinnamate and benzyl salicylate. PubMed: Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. PubMed: Benzyl salicylate: a survey of consumer patch-test sensitization. PubMed: Fragrance material review on benzyl salicylate. PubMed: Smooth muscle relaxant action of benzyl benzoates and salicylic acid derivatives from Brickellia veronicaefolia on isolated guinea-pig ileum. PubMed: Immunobiological [correction of Immunobioloical] activity of a new benzyl benzoate from the aerial parts of Solidago virga-aurea var. gigantea. PubMed: Intensified contact sensitization to benzyl salicylate. Phototoxic effects of topical psoralen therapy. PubMed: INTRA-ARTICULAR BENZYL SALICYLATE THERAPY IN OSTEOARTHRITIS OF THE KNEE. PubMed: Nontargeted GC-MS approach for volatile profile of toasting in cherry, chestnut, false acacia, and ash wood. PubMed: Propolis from northern California and Oregon: chemical composition, botanical origin, and content of allergens. PubMed: Enzymes of the mandelate pathway in Bacterium N.C.I.B. 8250. PubMed: [GC-MS analysis of chemical constituents of volatile oil from flowers of Rhododendron mucronatum]. PubMed: Headspace solid-phase microextraction-gas chromatography-mass spectrometry characterization of propolis volatile compounds. PubMed: Dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry for the rapid and sensitive determination of UV filters in environmental water samples. PubMed: Structural modifications of salicylates: inhibitors of human CD81-receptor HCV-E2 interaction. PubMed: Profiling of volatile compounds of Phyllostachys pubescens shoots in Taiwan. PubMed: Identification of methyl salicylate as the principal volatile component in the methanol extract of root bark of Securidaca longepedunculata Fers. PubMed: Preparation of lipophilic alkyl (hydroxy)benzoates by solvent-free lipase-catalyzed esterification and transesterification. PubMed: Structural basis of ligand interactions of the large extracellular domain of tetraspanin CD81. PubMed: The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. PubMed: Occurrence and profiles of organic sun-blocking agents in surface waters and sediments in Japanese rivers and lakes. PubMed: Determination of suspected allergens in cosmetic products by headspace-programmed temperature vaporization-fast gas chromatography-quadrupole mass spectrometry. PubMed: Hydrostatic countercurrent chromatography and ultra high pressure LC: Two fast complementary separation methods for the preparative isolation and the analysis of the fragrant massoia lactones. PubMed: Male sex pheromone of cockroachEurycotis floridana (walker) (Blattidae, Polyzosteriinae): Role and composition of tergites 2 and 8 secretions. PubMed: Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction. PubMed: Jasminum flexile flower absolute from India--a detailed comparison with three other jasmine absolutes. PubMed: Effect of components of resilient denture-lining materials on the growth, acid production and colonization of Candida albicans. PubMed: Influence of plasticizer on soft polymer gelation. PubMed: Plant extracts affect in vitro rumen microbial fermentation. PubMed: Fragrance contact dermatitis: a worldwide multicenter investigation (Part I). PubMed: Regulation of simultaneous synthesis of floral scent terpenoids by the 1,8-cineole synthase of Nicotiana suaveolens. PubMed: Sensitization to 26 fragrances to be labelled according to current European regulation. Results of the IVDK and review of the literature. PubMed: High-performance liquid chromatographic method for the simultaneous determination of 24 fragrance allergens to study scented products. PubMed: Estrogenic activity of UV filter mixtures. PubMed: Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. PubMed: Allergic contact dermatitis from propolis. PubMed: Leaching of plasticizers from temporary denture soft lining materials. PubMed: Estrogenic activity of tissue conditioners in vitro. PubMed: The historical aspects of sunscreens. PubMed: Studies of new short-period method for delayed contact hypersensitivity assay in the guinea pig. (2). Studies of the enhancement effect of cyclophosphamide. PubMed: Studies of new short-period method for delayed contact hypersensitivity assay in the guinea pig. (I). Development and comparison with other methods. PubMed: [Study of toxicokinetics and cumulative properties of salicylic acid derivatives]. PubMed: Propolis allergy. (III). Sensitization studies with minor constituents. PubMed: Differential hypermelanosis induced by allergic contact dermatitis.