isopropyl palmitate

isopropyl hexadecanoate

CAS: 142-91-6 C19 H38 O2 MW: 298.51026000

Identification

Nameisopropyl palmitate
IUPACpropan-2-yl hexadecanoate
CAS Number142-91-6
EINECS205-571-1
FDA UNII8CRQ2TH63M
Molecular FormulaC19 H38 O2
Molecular Weight298.51026000
MDL NumberMFCD00008993
Nikkaji NumberJ11.002G
Beilstein1786567
CoE Number10732

Regulatory

DG SANTE Food Flavourings09.606 isopropyl hexadecanoate
FDA Mainterm (SATF)142-91-6 ; ISOPROPYL PALMITATE

Physical Properties

Appearance colorless clear oily liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.85200 to 0.85800 @ 25.00 °C.
Pounds per Gallon - (est). 7.089 to 7.139
Refractive Index 1.43300 to 1.43900 @ 20.00 °C.
Melting Point 13.00 °C. @ 760.00 mm Hg
Boiling Point 342.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.000084 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 8.272 (est)
Soluble in alcohol
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantistatic agents

Organoleptic Properties

Odor Strength none
Substantivity 208 Hour(s)
Odor Description at 100.00 %.
Odor sample from Ungerer & Company, Inc.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 [sex: M,F] > 40000 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysolvents/deluents for flavor and/or fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for isopropyl palmitate usage levels up to25.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)3900 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
Dairy products, excluding products of category 02.0 (01.0)7.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)5.00000
Edible ices, including sherbet and sorbet (03.0)10.00000
Processed fruit (04.1)7.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)10.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)5.00000
Bakery wares (07.0)10.00000
Meat and meat products, including poultry and game (08.0)2.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)2.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)5.00000
Foodstuffs intended for particular nutritional uses (13.0)10.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)5.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)10.00000
Ready-to-eat savouries (15.0)20.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)5.00000

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Jiangyin Healthway International Trade Co., Ltd

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Vigon International

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Manufacturer and supplier of high quality flavor and fragrance ingredients.

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Potential Uses

antistatic agents binding agents emollients skin conditioning solvents

Natural Occurrence

acacia concinna buckwheat citrus fruits PMC macadamia nut - up to 0.04 mg/kg psidium salutare

Synonyms

crestalan crodamol IPP deltyl deltyl prime NF dermol IPP edenor IEP 19 emcol-IP emerest 2316 hallstar IPP hallstar IPP-NF hexadecanoic acid 1-methyl ethyl ester hexadecanoic acid 1-methylethyl ester hexadecanoic acid isopropyl ester hexadecanoic acid, 1-methylethyl ester liponate IPP 1- methyl ethyl hexadecanoate 1- methylethyl hexadecanoate nikkol IPP nikkol IPP-EX iso pal palmitato de isopropila palmitic acid isopropyl ester propal propan-2-yl hexadecanoate iso propyl hexadecanoate iso propyl N-hexadecanoate iso propyl palmitate NF iso propylpalmitate sinnoester PIT unimate IPP wickenol 111 PubMed: Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery. PubMed: Evaluation of nicotinamide microemulsion on the skin penetration enhancement. PubMed: Preparation and in vitro evaluation of a pluronic lecithin organogel containing ricinoleic acid for transdermal delivery. PubMed: Permeation study through bacterial cellulose membrane. PubMed: FA-loaded lipid drug delivery systems: preparation, characterization and biological studies. PubMed: Propolis organogel as a novel topical delivery system for treating wounds. PubMed: Mechanistic investigation and reversible effect of 2-isopropyl-5-methylcyclohexyl heptanoate on the in vitro percutaneous absorption of indomethacin. PubMed: Chemical composition and antifungal activity of Matricaria recutita flower essential oil against medically important dermatophytes and soil-borne pathogens. PubMed: Analysis of isopropyl para-toluenesulphonate in palm-based esters by gas chromatography with flame ionization detection and confirmed with mass spectrometry. PubMed: Effect of the stability of hydrogen-bonded ion pairs with organic amines on transdermal penetration of teriflunomide. PubMed: Polyglycerol fatty acid ester surfactant-based microemulsions for targeted delivery of ceramide AP into the stratum corneum: formulation, characterisation, in vitro release and penetration investigation. PubMed: Effect of (E)-2-isopropyl-5-methylcyclohexyl octadec-9-enoate on transdermal delivery of Aconitum alkaloids. PubMed: Topical delivery of flurbiprofen from pluronic lecithin organogel. PubMed: Foreign body reaction to bone wax an unusual cause of persistent serous discharge from iliac crest graft donor site and the possible means to avoid such complication - a case report. PubMed: Pluronic lecithin organogel as a topical drug delivery system. PubMed: Aggregation pheromone compounds of the black larder beetle Dermestes haemorrhoidalis Kuster (Coleoptera: Dermestidae). PubMed: Microemulsions as a surrogate carrier for dermal drug delivery. PubMed: Aerosol OT microemulsions as carriers for transdermal delivery of hydrophobic and hydrophilic local anesthetics. PubMed: The role of capillary force promoters in dry coating procedures--evaluation of acetylated monoglyceride, isopropyl myristate and palmitate. PubMed: Preparation and evaluation of diltiazem hydrochloride diffusion-controlled transdermal delivery system. PubMed: Comedogenicity in rabbit: some cosmetic ingredients/vehicles. PubMed: [Screening of Panax notoginsenoside water in oil microemulsion formulations and their evaluation in vitro and in vivo]. PubMed: Enhancement of the skin permeation of clindamycin phosphate by Aerosol OT/1-butanol microemulsions. PubMed: Assessment of oil polarity: comparison of evaluation methods. PubMed: Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions. PubMed: Transdermal permeability of N-acetyl-D-glucosamine. PubMed: Effect of penetration enhancers on skin permeation of trazodone hydrochloride from matrix type transdermal formulation through mouse and human cadaver epidermis. PubMed: Lecithin organogels used as bioactive compounds carriers. A microdomain properties investigation. PubMed: Characterisation of microstructures formed in isopropyl palmitate/water/Aerosol OT:1-butanol (2:1) system. PubMed: Effects of isopropyl palmitate on the skin permeation of drugs. PubMed: Microemulsions as transdermal drug delivery vehicles. PubMed: Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments. PubMed: The hairless guinea-pig as a model for treatment of acute irritation in humans. PubMed: Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/water/Brij 97:1-butanol. PubMed: [Analysis of constituents of essential oil from the skin of water caltrop]. PubMed: Effect of oil phase lipophilicity on in vitro drug release from o/w microemulsions with low surfactant content. PubMed: The hairless guinea-pig as a model for treatment of cumulative irritation in humans. PubMed: Phase behavior of the microemulsions and the stability of the chloramphenicol in the microemulsion-based ocular drug delivery system. PubMed: Biocompatible lecithin organogels: structure and phase equilibria. PubMed: New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. PubMed: Microemulsions for dermal drug delivery studied by dynamic light scattering: effect of interparticle interactions in oil-in-water microemulsions. PubMed: Effect of hydrophobic permeation enhancers on the release and skin permeation kinetics from matrix type transdermal drug delivery system of ketotifen fumarate. PubMed: A repeat-batch membrane bioreactor with a phase inversion for the desaturation of isopropyl palmitate by a mutant Rhodococcus strain. PubMed: Stable reversed vesicles in oil: characterization studies and encapsulation of model compounds. PubMed: Direct micellar systems as a tool to improve the efficiency of aromatic substrate conversion for fine chemicals production. PubMed: Production of isopropyl cis-6-hexadecenoate by regiospecific desaturation of isopropyl palmitate by a double mutant of a Rhodococcus strain. PubMed: Studies on the kinetics of Isopropyl Palmitate synthesis in packed bed bioreactor using immobilized lipase. PubMed: Skin healing preparations: compared in vitro diffusion of the active ingredients. PubMed: Human skin irritation studies of a lecithin microemulsion gel and of lecithin liposomes. PubMed: The adjuvancy of silicones: dependency on compartmentalization. PubMed: [The effect of ibuprofen on the composition of tissue lipids in an experiment]. PubMed: Lecithin organogel as matrix for transdermal transport of drugs. PubMed: Osseous regeneration in the presence of four common hemostatic agents. PubMed: Solubilization and activity of yeast cells in water-in-oil microemulsion. PubMed: Iatrogenic fenestration of a semicircular canal: a method of closure. PubMed: Solubilization of bacterial cells in organic solvents via reverse micelles. PubMed: Histological changes in rabbits after application of medicaments and cosmetic bases (III). PubMed: Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear. PubMed: Selection of the acceptor medium in in vitro measurements of drug release from dermatological ointments. PubMed: Contact allergy to benzyl alcohol and isopropyl palmitate, ingredients of topical corticosteroid. PubMed: Eye and skin irritation tests on the rabbit of several fatty acid esters.