acetyl-laevo-aspartic acid

acetylaspartic acid

CAS: 997-55-7 C6 H9 N O5 MW: 175.14073000

Identification

Nameacetyl-laevo-aspartic acid
IUPAC(2S)-2-acetamidobutanedioic acid
CAS Number997-55-7
EINECS213-643-9
FDA UNII445Y04YIWR
Molecular FormulaC6 H9 N O5
Molecular Weight175.14073000
MDL NumberMFCD00020500
Nikkaji NumberJ62.824G
Beilstein1726198
XlogP3-1.10 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 1e+006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for acetyl-laevo-aspartic acid usage levels up tonot for fragrance use.
Recommendation for acetyl-laevo-aspartic acid flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

(2S)-2- acetamidobutanedioic acid acetyl aspartic acid acetyl-L-aspartic acid N- acetyl-laevo-aspartic acid acetylaspartic acid aspartic acid, N-acetyl-, L- (8CI) PubMed: A multi-matrix HILIC-MS/MS method for the quantitation of endogenous small molecule neurological biomarker N-acetyl aspartic acid (NAA). PubMed: The positive effects of high-frequency right dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation on memory, correlated with increases in brain metabolites detected by proton magnetic resonance spectroscopy in recently detoxified alcohol-dependent patients. PubMed: Evaluation of skin firmness by the DynaSKIN, a novel non-contact compression device, and its use in revealing the efficacy of a skincare regimen featuring a novel anti-ageing ingredient, acetyl aspartic acid. PubMed: Elevated Glutamate Levels in the Left Dorsolateral Prefrontal Cortex Are Associated with Higher Cravings for Alcohol. PubMed: rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System. PubMed: Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS. PubMed: Structural activity relationship analysis (SAR) and in vitro testing reveal the anti-ageing potential activity of acetyl aspartic acid. PubMed: In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmness. PubMed: Pre-clinical formulation screening, development and stability of acetyl aspartic acid for cosmetic application. PubMed: In vitro and in vivo dermal absorption assessment of acetyl aspartic acid: a compartmental study. PubMed: Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proof. PubMed: Safety assessment of a novel active ingredient, acetyl aspartic acid, according to the EU Cosmetics Regulation and the Scientific Committee on Consumer Safety guidelines. PubMed: The use of gene arrays and corresponding connectivity mapping (Cmap) to identify novel anti-ageing ingredients. PubMed: Making the White Matter Matters: Progress in Understanding Canavan's Disease and Therapeutic Interventions Through Eight Decades. PubMed: A facile means for the identification of indolic compounds from plant tissues. PubMed: Oral cysteamine bitartrate and N-acetylcysteine for patients with infantile neuronal ceroid lipofuscinosis: a pilot study. PubMed: Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer's disease mouse model. PubMed: Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods. PubMed: [Megalencephaly with dystonia revealing Canavan disease]. PubMed: [Analysis of ¹H-MRS in patients with depression after basal ganglia infarction]. PubMed: Computational analysis of deleterious missense mutations in aspartoacylase that cause Canavan's disease. PubMed: Proton magnetic resonance spectroscopy in the evaluation of infiltration zone of cerebral alveolar echinococcosis. PubMed: A mutation of aspartoacylase gene in a Turkish patient with Canavan disease. PubMed: Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry. PubMed: A missense mutation (p.G274R) in gene ASPA causes Canavan disease in a Pakistani family. PubMed: Direct detection of diverse metabolic changes in virally transformed and tax-expressing cells by mass spectrometry. PubMed: Functional changes in the frontal cortex in Parkinson's disease using a rat model. PubMed: T2 corrected quantification method of L-p-boronophenylalanine using proton magnetic resonance spectroscopy for boron neutron capture therapy. PubMed: [Canavan disease or N-acetyl aspartic aciduria: a case report]. PubMed: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter]. PubMed: Metabolic parameters of epilepsy: adjuncts to established antiepileptic drug therapy. PubMed: Overexpression of a bacterial indole-3-acetyl-l-aspartic acid hydrolase in Arabidopsis thaliana. PubMed: [Magnetic resonance spectroscopy and functional magnetic resonance images: non-invasive alternatives for identifying epileptogenic foci]. PubMed: High-resolution proton nuclear magnetic resonance spectroscopy of ovarian cyst fluid. PubMed: Brain imaging of affective disorders and schizophrenia. PubMed: [The EAA-ergic modulation of the brain dopaminergic system as a basis for creating new nootropic agents with stress-protective activity]. PubMed: [MRI, SPECT and MRS findings in a case of acute hemiplegia syndrome with a marked hemispheric brain edema]. PubMed: The gene for indole-3-acetyl-L-aspartic acid hydrolase from Enterobacter agglomerans: molecular cloning, nucleotide sequence, and expression in Escherichia coli. PubMed: Metabolism of indole-3-acetic acid in Arabidopsis. PubMed: High-resolution 1H NMR spectroscopy following experimental brain trauma. PubMed: Methylphenidate increases rat cerebral cortex levels of N-acetyl-aspartic acid and N-acetyl-aspartyl-glutamic acid. PubMed: Analysis of cerebral structural changes in systemic lupus erythematosus by proton MR spectroscopy. PubMed: [The evaluation of the effects of piracetam and N-acetylaspartic acid on memory and the content of mediator amino acids in the brain in a model neurotic state in rats]. PubMed: [Effects of N-acetylasparaginic acid during frontal lobectomy in the rat: antiamnestic action and effect on monoamine level]. PubMed: [Longitudinal change of H-1 spectroscopy in cerebral infarction]. PubMed: [The effect of N-acetylaspartic acid on the processes of memory and learning in rats]. PubMed: N-acetylaspartic aciduria in Canavan disease: another proof in two infants. PubMed: N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. PubMed: Effects of gibberellic Acid on endogenous indole-3-acetic Acid and indoleacetyl aspartic Acid levels in a dwarf pea. PubMed: The influence of small direct electric currents on the transport of auxin in intact plants. PubMed: [Transport of [(14)C] auxin from young pods of Vicia faba L]. PubMed: Studies on the movement of indole auxins in willow (Salix viminalis L.). PubMed: The transport and metabolism of (14)C-labelled indoleacetic acid in intact pea seedlings. PubMed: [Studies on the uptake of naphthalene-1-acetic acid and its aspartic acid conjugate into wheat coleoptile tissue]. PubMed: Growth substances from Veratrum tenuipetalum. PubMed: Acetyl transport mechanisms. Involvement of N-acetyl aspartic acid in de novo fatty acid biosynthesis in the developing rat brain. PubMed: Brain amino acid uptake: the effect of L-aspartic acid, L-N-acetyl aspartic acid, and L-asparagine administration in the rat. PubMed: Utilization in vivo of glucose and volatile fatty acids by sheep brain for the synthesis of acidic amino acids. PubMed: A method for the gas-chromatographic analysis of N-acetyl-aspartic acid in brain. PubMed: [On the use of acetyl-aspartic acid and of citrulline in the treatment and prevention of flight fatigue]. PubMed: Studies on the function of N-acetyl aspartic acid in brain. PubMed: FUNCTION OF N-ACETYL ASPARTIC ACID IN THE BRAIN: EFFECTS OF CERTAIN DRUGS. PubMed: [N-ACETYL-ASPARTIC ACID IN NERVE TISSUE. QUANTITATIVE CHANGES IN THE BRAIN OF GROWING ANIMALS].