butylated hydroxymethyl phenol
benzenemethanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-
Identification
| Name | butylated hydroxymethyl phenol |
| IUPAC | 2,6-di-tert-butyl-4-(hydroxymethyl)phenol |
| CAS Number | 88-26-6 |
| EINECS | 201-815-6 |
| FDA UNII | 46ND6GQI48 |
| Molecular Formula | C15 H24 O2 |
| Molecular Weight | 236.35468000 |
| MDL Number | MFCD00017254 |
| Nikkaji Number | J12.804J |
| Beilstein | 2052291 |
Regulatory
| FDA Mainterm (SATF) | 88-26-6 ; 4-HYDROXYMETHYL-2,6-DI-TERTBUTYLPHENOL |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 306.00 to 307.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000330 mmHg @ 25.00 °C. (est) |
| Flash Point | 268.00 °F. TCC ( 131.20 °C. ) (est) |
| logP (o/w) | 3.504 (est) |
| Soluble in | water, 312.6 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LDLo 7000 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antioxidants and stabilizers |
| Recommendation for butylated hydroxymethyl phenol usage levels up to | not for fragrance use. |
| Recommendation for butylated hydroxymethyl phenol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
antioxidant 754
benzenemethanol, 3,5-bis (1,1-dimethylethyl)-4-hydroxy-
benzenemethanol, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-
benzyl alcohol, 3,5-di-t-butyl-4-hydroxy-
benzyl alcohol, 3,5-di-tert-butyl-4-hydroxy-
BHT alcohol
2,6-bis(tert-
butyl)-4-(hydroxymethyl)phenol
3,5-
di-t-butyl-4-hydroxybenzyl alcohol
2,6-
di-t-butyl-4-hydroxymethylphenol
2,6-
di-tert-butyl-4-(hydroxymethyl)benzolol
2,6-
di-tert-butyl-4-(hydroxymethyl)phenol
3,5-
di-tert-butyl-4-hydroxybenzyl alcohol
3,5-
di-tert-butyl-4-hydroxybenzylalcohol
di-tert-butyl-4-hydroxymethyl phenol
2,6-
di-tert-butyl-4-hydroxymethyl phenol
2,6-
di-tert-butyl-4-hydroxymethylphenol
3,5-bis(1,1-
dimethyl ethyl)-4-hydroxybenzene methanol
2,6-bis(1,1-
dimethylethyl)-4-(hydroxymethyl)phenol
3,5-bis(1,1-
dimethylethyl)-4-hydroxybenzene methanol
3,5-bis(1,1-
dimethylethyl)-4-hydroxybenzenemethanol
alpha-
hydroxy-2,6-di-tert-butyl-p-cresol
alpha-
hydroxy-2,6-di-tert-butyl-para-cresol
4-
hydroxymethyl-2,6-di-tert-butylphenol
4-
hydroxymethyl-2,6-di-tertbutylphenol
4-(
hydroxymethyl)-2,6-bis(2-methyl-2-propanyl)phenol
butylated
hydroxymethylphenol
ionox 100 antioxidant
PubMed:
Oxidation of synthetic phenolic antioxidants during water chlorination.
PubMed:
Identification of phenolic dermal sensitizers in a wound closure tape.
PubMed:
Comparative study on the antioxidant and biological activities of carvacrol, thymol, and eugenol derivatives.
PubMed:
Simultaneous determination of five synthetic antioxidants in edible vegetable oil by GC-MS.
PubMed:
The relationship between the physicochemical properties of antioxidants and their ability to inhibit lipid oxidation in bulk oil and oil-in-water emulsions.
PubMed:
Antioxidants reversibly inhibit the spontaneous resumption of meiosis.
PubMed:
Selective induction of apoptosis in mouse and human lung epithelial cell lines by the tert-butyl hydroxylated metabolite of butylated hydroxytoluene: a proposed role in tumor promotion.
PubMed:
Contact allergy to 2-hydroxy-5-tert-butyl benzylalcohol and 2,6-bis(hydroxymethyl)-4-tert-butylphenol, components of a phenolic resin used in marking pens.
PubMed:
DNA cleavage by metabolites of butylated hydroxytoluene.
PubMed:
Butylated hydroxyanisole specifically inhibits tumor necrosis factor-induced cytotoxicity and growth enhancement.
PubMed:
A metabolite of butylated hydroxytoluene with potent tumor-promoting activity in mouse lung.
PubMed:
Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice.
PubMed:
Bisulfite induced lipid oxidation.