astacin

beta,beta- carotene-3,3',4,4'-tetrone 4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-(3,4- diketo-2,6,6-trimethyl-1-cyclohexenyl)-3,7,12,16-tetramethyl-octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethyl-cyclohex-3-ene-1,2-quinone 3,5,5- trimethyl-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-3,4-dioxocyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohex-3-ene-1,2-dione PubMed: Characterisation of protein families in spider digestive fluids and their role in extra-oral digestion. PubMed: Cleavage of the Drosophila seminal protein Acp36DE in mated females enhances its sperm storage activity. PubMed: First insight into structure-activity relationships of selective meprin β inhibitors. PubMed: Investigating proteins and proteases composing amniotic and allantoic fluids during chicken embryonic development. PubMed: Meprin β and BMP-1 are differentially regulated by CaCl2. PubMed: Duplications and Positive Selection Drive the Evolution of Parasitism-Associated Gene Families in the Nematode Strongyloides papillosus. PubMed: Heterologous Expression of the Astacin Protease Meprin β in Pichia pastoris. PubMed: Functional Elucidation of Nemopilema nomurai and Cyanea nozakii Nematocyst Venoms' Lytic Activity Using Mass Spectrometry and Zymography. PubMed: The seahorse genome and the evolution of its specialized morphology. PubMed: Parasitological and transcriptomic comparison of Strongyloides ratti infections in natural and in suboptimal permissive hosts. PubMed: Recombinant fetuin-B protein maintains high fertilization rate in cumulus cell-free mouse oocytes. PubMed: Exocrine glands of Lepeophtheirus salmonis (Copepoda: Caligidae): Distribution, developmental appearance, and site of secretion. PubMed: High throughput techniques to reveal the molecular physiology and evolution of digestion in spiders. PubMed: Expression and immunological cross-reactivity of LALP3, a novel astacin-like metalloprotease from brown spider (Loxosceles intermedia) venom. PubMed: Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis. PubMed: Insights from Analysis of Binding Sites of Human Meprins: Screening of Inhibitors by Molecular Dynamics Simulation Study. PubMed: Handling Metalloproteinases. PubMed: The genomic basis of parasitism in the Strongyloides clade of nematodes. PubMed: Exceptional material requirement for reproduction in mouse oocytes. PubMed: Global Transcriptome Analysis of the Tentacle of the Jellyfish Cyanea capillata Using Deep Sequencing and Expressed Sequence Tags: Insight into the Toxin- and Degenerative Disease-Related Transcripts. PubMed: Sturgeon hatching enzyme and the mechanism of egg envelope digestion: Insight into changes in the mechanism of egg envelope digestion during the evolution of ray-finned fish. PubMed: Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity. PubMed: Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors. PubMed: Origin and Diversification of Meprin Proteases. PubMed: Expression, purification and initial characterization of human meprin β from Pichia pastoris. PubMed: Proteomics of ionomycin-induced ascidian sperm reaction: Released and exposed sperm proteins in the ascidian Ciona intestinalis. PubMed: The venomous cocktail of the vampire snail Colubraria reticulata (Mollusca, Gastropoda). PubMed: Metalloproteinases: A parade of functions in matrix biology and an outlook for the future. PubMed: Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis. PubMed: Biochemical, transcriptomic and proteomic analyses of digestion in the scorpion Tityus serrulatus: insights into function and evolution of digestion in an ancient arthropod. PubMed: Identification of the Mamestra configurata (Lepidoptera: Noctuidae) peritrophic matrix proteins and enzymes involved in peritrophic matrix chitin metabolism. PubMed: A highly conserved, inhibitable astacin metalloprotease from Teladorsagia circumcincta is required for cuticle formation and nematode development. PubMed: A novel mechanism of latency in matrix metalloproteinases. PubMed: Plectreurys tristis venome: A proteomic and transcriptomic analysis. PubMed: Xhe2 is a member of the astacin family of metalloproteases that promotes Xenopus hatching. PubMed: Comparison of hatching mode in pelagic and demersal eggs of two closely related species in the order pleuronectiformes. PubMed: Biochemical and proteomic characterisation of haemolymph serum reveals the origin of the alkali-labile phosphate (ALP) in mussel (Mytilus galloprovincialis). PubMed: Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis. PubMed: Characterization and neutralization of Nemopilema nomurai (Scyphozoa: Rhizostomeae) jellyfish venom using polyclonal antibody. PubMed: Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins. PubMed: A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity. PubMed: Structure and mechanism of a type III secretion protease, NleC. PubMed: Physicochemical properties of the modeled structure of astacin metalloprotease moulting enzyme NAS-36 and mapping the druggable allosteric space of Heamonchus contortus, Brugia malayi and Ceanorhabditis elegans via molecular dynamics simulation. PubMed: Functional similarity and molecular divergence of a novel reproductive transcriptome in two male-pregnant Syngnathus pipefish species. PubMed: Spit and venom from scytodes spiders: a diverse and distinct cocktail. PubMed: Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study. PubMed: Meprin-β regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages. PubMed: SAS1B protein [ovastacin] shows temporal and spatial restriction to oocytes in several eutherian orders and initiates translation at the primary to secondary follicle transition. PubMed: Differential metalloprotease content and activity of three Loxosceles spider venoms revealed using two-dimensional electrophoresis approaches. PubMed: [Structural properties and functional importance of metzincin metalloproteinases]. PubMed: Potential tumor biomarkers identified in ovarian cyst fluid by quantitative proteomic analysis, iTRAQ. PubMed: Meprin A metalloproteinase and its role in acute kidney injury. PubMed: Molecular cloning and characterisation of in vitro immune response against astacin-like metalloprotease Ace-MTP-2 from Ancylostoma ceylanicum. PubMed: Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3. PubMed: Functional and structural insights into astacin metallopeptidases. PubMed: An oocyte-specific astacin family protease, alveolin, is released from cortical granules to trigger egg envelope hardening during fertilization in medaka (Oryzias latipes). PubMed: Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration. PubMed: Theoretical investigation of astacin proteolysis. PubMed: Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish. PubMed: Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy. PubMed: Molecular cloning and characterization of hatching enzyme-like geneII (BmHELII) in the silkworm, Bombyx mori. PubMed: Differential expression profiling of orange-spotted grouper larvae, Epinephelus coioides (Hamilton), that survived a betanodavirus outbreak. PubMed: Metal preferences of zinc-binding motif on metalloproteases. PubMed: Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis. PubMed: The Drosophila melanogaster seminal fluid protease "seminase" regulates proteolytic and post-mating reproductive processes. PubMed: Expression profiling, gene silencing and transcriptional networking of metzincin metalloproteases in the cattle tick, Rhipicephalus (Boophilus) microplus. PubMed: Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta. PubMed: Life cycle stage-resolved proteomic analysis of the excretome/secretome from Strongyloides ratti--identification of stage-specific proteases. PubMed: First transcriptome of the testis-vas deferens-male accessory gland and proteome of the spermatophore from Dermacentor variabilis (Acari: Ixodidae). PubMed: Spinning gland transcriptomics from two main clades of spiders (order: Araneae)--insights on their molecular, anatomical and behavioral evolution. PubMed: Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. PubMed: Bone morphogenetic protein (BMP)1-3 enhances bone repair. PubMed: Strongyloides stercoralis excretory/secretory protein strongylastacin specifically recognized by IgE antibodies in infected human sera. PubMed: Transcripts analysis of infective larvae of an intestinal nematode, Strongyloides venezuelensis. PubMed: Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. PubMed: The astacin metalloprotease moulting enzyme NAS-36 is required for normal cuticle ecdysis in free-living and parasitic nematodes. PubMed: Intron-loss evolution of hatching enzyme genes in Teleostei. PubMed: Crystal structure of zebrafish hatching enzyme 1 from the zebrafish Danio rerio. PubMed: Astacin proteases cleave dentin sialophosphoprotein (Dspp) to generate dentin phosphoprotein (Dpp). PubMed: Cloning, characterisation and heterologous expression of an astacin metalloprotease, Sc-AST, from the entomoparasitic nematode Steinernema carpocapsae. PubMed: A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis. PubMed: Processing of procollagen III by meprins: new players in extracellular matrix assembly? PubMed: First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles. PubMed: Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. PubMed: Proenzyme structure and activation of astacin metallopeptidase. PubMed: Hatching mechanism of the Chinese soft-shelled turtle Pelodiscus sinensis. PubMed: Characterization of the astacin family of metalloproteases in C. elegans. PubMed: Collagen processing and cuticle formation is catalysed by the astacin metalloprotease DPY-31 in free-living and parasitic nematodes. PubMed: Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles). PubMed: Activation of mammalian Tolloid-like 1 expression by hypoxia in human neuroblastoma SH-SY5Y cells. PubMed: A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice. PubMed: Acclimatory responses of the Daphnia pulex proteome to environmental changes. II. Chronic exposure to different temperatures (10 and 20 degrees C) mainly affects protein metabolism. PubMed: Ecological function of myroilysin, a novel bacterial M12 metalloprotease with elastinolytic activity and a synergistic role in collagen hydrolysis, in biodegradation of deep-sea high-molecular-weight organic nitrogen. PubMed: Tolliod-like gene in Crassostrea ariakensis: Molecular cloning, structural characterization and expression by RLO stimulation. PubMed: [The astacin family of metalloproteinases]. PubMed: News from an ancient world: two novel astacin metalloproteases from the horseshoe crab. PubMed: Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases. PubMed: Special issue: metzincin metalloproteinases. PubMed: Meprins, membrane-bound and secreted astacin metalloproteinases. PubMed: A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin. PubMed: Analysis of genes isolated from plated hemocytes of the Pacific oyster, Crassostreas gigas. PubMed: The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion. PubMed: Identification of softness syndrome-associated candidate genes and DNA sequence variation in the sea squirt, Halocynthia roretzi. PubMed: Comparative expression and tissue distribution analyses of astacin-like squid metalloprotease in squid and cuttlefish. PubMed: cDNA microarray analyses reveal candidate marker genes for the detection of ascidian disease in Korea. PubMed: Biotechnological applications of brown spider (Loxosceles genus) venom toxins. PubMed: The midgut transcriptome of Lutzomyia longipalpis: comparative analysis of cDNA libraries from sugar-fed, blood-fed, post-digested and Leishmania infantum chagasi-infected sand flies. PubMed: Identifying common metalloprotease inhibitors by protein fold types using Fourier transform mass spectrometry. PubMed: Identification of midgut microvillar proteins from Tenebrio molitor and Spodoptera frugiperda by cDNA library screenings with antibodies. PubMed: Identification, cloning, expression and functional characterization of an astacin-like metalloprotease toxin from Loxosceles intermedia (brown spider) venom. PubMed: Two alpha subunits and one beta subunit of meprin zinc-endopeptidases are differentially expressed in the zebrafish Danio rerio. PubMed: The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains. PubMed: Microarray analyses of newborn mouse ovaries lacking Nobox. PubMed: Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus. PubMed: Compartmentalised expression of meprin in small intestinal mucosa: enhanced expression in lamina propria in coeliac disease. PubMed: Molecular cloning and characterization of Ac-MTP-2, an astacin-like metalloprotease released by adult Ancylostoma caninum. PubMed: Pf-ALMP, a novel astacin-like metalloproteinase with cysteine arrays, is abundant in hemocytes of pearl oyster Pinctada fucata. PubMed: Gene cooption without duplication during the evolution of a male-pregnancy gene in pipefish. PubMed: Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster. PubMed: Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin. PubMed: Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer. PubMed: Evolution of teleostean hatching enzyme genes and their paralogous genes. PubMed: cDNA cloning, purification and properties of Paralithodes camtschatica metalloprotease. PubMed: The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1. PubMed: Developmental roles of the BMP1/TLD metalloproteinases. PubMed: Characterization of astaxanthin esters in Haematococcus pluvialis by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. PubMed: A survey of the intestinal transcriptomes of the hookworms, Necator americanus and Ancylostoma caninum, using tissues isolated by laser microdissection microscopy. PubMed: Evolution of astacin-like metalloproteases in animals and their function in development. PubMed: Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains. PubMed: Overexpression and mechanistic characterization of blastula protease 10, a metalloprotease involved in sea urchin embryogenesis and development. PubMed: Astacin family metallopeptidases and serine peptidase inhibitors in spider digestive fluid. PubMed: Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. PubMed: Biomimetic zinc funnel complexes based on calix[6]N3ArO ligands: an acid-base switch for guest binding. PubMed: Expression and tissue distribution of astacin-like squid metalloprotease (ALSM). PubMed: Cloning of a quail homologue of hatching enzyme: its conserved function and additional function in egg envelope digestion. PubMed: Identification of an astacin-like metallo-proteinase transcript from the infective larvae of Strongyloides stercoralis. PubMed: cimp1, a novel astacin family metalloproteinase gene from East African cichlids, is differentially expressed between species during growth. PubMed: Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1). PubMed: Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi. PubMed: Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target. PubMed: Metalloproteases with EGF, CUB, and thrombospondin-1 domains function in molting of Caenorhabditis elegans. PubMed: Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish. PubMed: Structure and developmental expression of hatching enzyme genes of the Japanese eel Anguilla japonica: an aspect of the evolution of fish hatching enzyme gene. PubMed: Solubility properties of a 65-kDa peptide prepared by restricted digestion of myosin with astacin-like squid metalloprotease. PubMed: Purification and cloning of an endogenous protein inhibitor of carp nephrosin, an astacin metalloproteinase. PubMed: The astacin protein family in Caenorhabditis elegans. PubMed: The role of the matrix metalloproteinases in human endometrial and ovarian cycles. PubMed: Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. PubMed: Meprin proteolytic complexes at the cell surface and in extracellular spaces. PubMed: Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease. PubMed: Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity. PubMed: Differences in the activation mechanism between the alpha and beta subunits of human meprin. PubMed: Characterization and cloning of metallo-proteinase in the excretory/secretory products of the infective-stage larva of Trichinella spiralis. PubMed: Expression of meprins in health and disease. PubMed: The Cu(II) acetate complex of the heteroscorpionate ligand (2-hydroxy-3-t-butyl-methylphenyl)bis(3,5-dimethylpyrazolyl)methane: a structural model for copper-substituted serralysin and astacin. PubMed: Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin. PubMed: Activation mechanism of pro-astacin: role of the pro-peptide, tryptic and autoproteolytic cleavage and importance of precise amino-terminal processing. PubMed: Zinc ligands in an astacin family metalloprotease meprin A. PubMed: Cloning and biochemical characterization of astacin-like squid metalloprotease. PubMed: Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion. PubMed: Structure, expression, and developmental function of early divergent forms of metalloproteinases in hydra. PubMed: Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system. PubMed: Purification and Biochemical Characterization of the Hatching Enzyme from Xenopus laevis. PubMed: The 1.35 A structure of cadmium-substituted TM-3, a snake-venom metalloproteinase from Taiwan habu: elucidation of a TNFalpha-converting enzyme-like active-site structure with a distorted octahedral geometry of cadmium. PubMed: Mechanistic studies of the astacin-like Serratia metalloendopeptidase serralysin: highly active (>2000%) Co(II) and Cu(II) derivatives for further corroboration of a "metallotriad" mechanism. PubMed: Arylamidase activity of neutral proteinase from Saccharomonospora canescens. Comparison with other Zn-proteinases that exhibit the same activity. PubMed: Characterization of the proteolytic enzymes in the midgut of the European Cockchafer, Melolontha melolontha (Coleoptera: Scarabaeidae). PubMed: Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen. PubMed: Expression cloning in ascidians: isolation of a novel member of the asctacin protease family. PubMed: A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. PubMed: Properties of the hatching enzyme from Xenopus laevis. PubMed: Simultaneous immunoblotting analysis with activity gel electrophoresis in a single polyacrylamide gel. PubMed: Comparing protein structures: a Gaussian-based approach to the three-dimensional structural similarity of proteins. PubMed: Activation of pro-astacin. Immunological and model peptide studies on the processing of immature astacin, a zinc-endopeptidase from the crayfish Astacus astacus. PubMed: Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity. PubMed: Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. PubMed: The roles of Glu93 and Tyr149 in astacin-like zinc peptidases. PubMed: Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. PubMed: Structure and function of procollagen C-proteinase (mTolloid) domains determined by protease digestion, circular dichroism, binding to procollagen type I, and computer modeling. PubMed: Identification and cDNA cloning of alveolin, an extracellular metalloproteinase, which induces chorion hardening of medaka (Oryzias latipes) eggs upon fertilization. PubMed: Hydra metalloproteinase 1: a secreted astacin metalloproteinase whose apical axis expression is differentially regulated during head regeneration. PubMed: Human N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin): genomic structure of the alpha and beta subunits. PubMed: Identification and characterization of hydra metalloproteinase 2 (HMP2): a meprin-like astacin metalloproteinase that functions in foot morphogenesis. PubMed: Heterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitro. PubMed: cDNA cloning, bacterial expression, in vitro renaturation and affinity purification of the zinc endopeptidase astacin. PubMed: Identification of an astacin matrix metalloprotease as target gene for Hydra foot activator peptides. PubMed: Purification and characterization of a novel isoform of myosinase from spear squid liver. PubMed: The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases. PubMed: Identification and localization of MEP1A-like sequences (MEP1AL1-4) in the human genome. PubMed: The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. PubMed: N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolyticprocessing and subsequent secretion. PubMed: A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11). PubMed: Nonpolarized secretion of human meprin alpha in colorectal cancer generates an increased proteolytic potential in the stroma. PubMed: Regulation of BMP signaling by the BMP1/TLD-related metalloprotease, SpAN. PubMed: Secretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunits. PubMed: The active site structure of tetanus neurotoxin resolved by multiple scattering analysis in X-Ray absorption spectroscopy. PubMed: A toxin homology domain in an astacin-like metalloproteinase of the jellyfish Podocoryne carnea with a dual role in digestion and development. PubMed: Cloning and characterization of a cDNA coding for Astacus embryonic astacin, a member of the astacin family of metalloproteases from the crayfish Astacus astacus. PubMed: Phosphinic peptides, the first potent inhibitors of astacin, behave as extremely slow-binding inhibitors. PubMed: Reprolysins and astacins...alive, alive-o. PubMed: Activation mechanism of meprins, members of the astacin metalloendopeptidase family. PubMed: C-cytosolic and transmembrane domains of the N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha subunit (human meprin alpha) are essential for its retention in the endoplasmic reticulum and C-terminal processing. PubMed: Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells. PubMed: Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the astacin family. PubMed: Kinetic characterization of the serralysins: a divergent catalytic mechanism pertaining to astacin-type metalloproteases. PubMed: Correlation of the exon/intron organization to the secondary structures of the protease domain of mouse meprin alpha subunit. PubMed: Species-dependent migration of fish hatching gland cells that express astacin-like proteases in common [corrected]. PubMed: Molecular cloning of Xenopus hatching enzyme and its specific expression in hatching gland cells. PubMed: Genomic organization of the zinc-endopeptidase astacin. PubMed: Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. PubMed: Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface. PubMed: A HhaI polymorphism in the human MEP1A gene encoding the alpha subunit of the metalloendopeptidase meprin. PubMed: hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1. PubMed: Structure of astacin with a transition-state analogue inhibitor. PubMed: Structure of the gene encoding the sea urchin blastula protease 10 (BP10), a member of the astacin family of Zn2+-metalloproteases. PubMed: BMP-1 and the astacin family of metalloproteinases: a potential link between the extracellular matrix, growth factors and pattern formation. PubMed: Characterization of a SpAN promoter sufficient to mediate correct spatial regulation along the animal-vegetal axis of the sea urchin embryo. PubMed: The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. PubMed: Different exon-intron organizations of the genes for two astacin-like proteases, high choriolytic enzyme (choriolysin H) and low choriolytic enzyme (choriolysin L), the constituents of the fish hatching enzyme. PubMed: X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily. PubMed: Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures. PubMed: X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin. PubMed: A novel meprin beta' mRNA in mouse embryonal and human colon carcinoma cells. PubMed: Mapping of the active site zinc ligands of peptide deformylase. PubMed: Matrilysin: expression, purification, and characterization. PubMed: Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin. PubMed: The astacin family of metalloendopeptidases. PubMed: A 25.7 x 10(3) M(r) hydra metalloproteinase (HMP1), a member of the astacin family, localizes to the extracellular matrix of Hydra vulgaris in a head-specific manner and has a developmental function. PubMed: Molecular cloning and sequence analysis of flavastacin: an O-glycosylated prokaryotic zinc metalloendopeptidase. PubMed: The metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases. PubMed: cDNA cloning and deduced amino acid sequence of prothrombin activator (ecarin) from Kenyan Echis carinatus venom. PubMed: Astacin. PubMed: Characterization of tolloid-related-1: a BMP-1-like product that is required during larval and pupal stages of Drosophila development. PubMed: The univin gene encodes a member of the transforming growth factor-beta superfamily with restricted expression in the sea urchin embryo. PubMed: Families of zinc metalloproteases. PubMed: The cleavage of the bait region of alpha 2-macroglobulin by human immunodeficiency virus proteinases and by astacin. PubMed: Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells. PubMed: The crystal structure of adamalysin II, a zinc-endopeptidase from the snake venom of the eastern diamondback rattlesnake Crotalus adamanteus. PubMed: Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself. PubMed: Crystal structures, spectroscopic features, and catalytic properties of cobalt(II), copper(II), nickel(II), and mercury(II) derivatives of the zinc endopeptidase astacin. A correlation of structure and proteolytic activity. PubMed: Refined 2.0 A X-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin. PubMed: Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain. PubMed: Retrospective analysis of a secondary structure prediction: the catalytic domain of matrix metalloproteinases. PubMed: Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A. PubMed: Expression of rat endopeptidase-24.18 in COS-1 cells: membrane topology and activity. PubMed: Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. PubMed: A kinetic comparison of the homologous proteases astacin and meprin A. PubMed: Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation. PubMed: Characterization of a homolog of human bone morphogenetic protein 1 in the embryo of the sea urchin, Strongylocentrotus purpuratus. PubMed: Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic. PubMed: Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor. PubMed: Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. PubMed: A new member to the astacin family of metalloendopeptidases: a novel 1,25-dihydroxyvitamin D-3-stimulated mRNA from chorioallantoic membrane of quail. PubMed: Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells. PubMed: Rat endopeptidase-24.18 alpha subunit is secreted into the culture medium as a zymogen when expressed by COS-1 cells. PubMed: Assignments for the main-chain nuclear magnetic resonances and delineation of the secondary structure of the catalytic domain of human stromelysin-1 as obtained from triple-resonance 3D NMR experiments. PubMed: The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications. PubMed: First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases. PubMed: Cloning, expression, and chromosomal localization of the mouse meprin beta subunit. PubMed: Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'. PubMed: Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif. PubMed: Implications of the three-dimensional structure of astacin for the structure and function of the astacin family of zinc-endopeptidases. PubMed: Refined 1.8 A X-ray crystal structure of astacin, a zinc-endopeptidase from the crayfish Astacus astacus L. Structure determination, refinement, molecular structure and comparison with thermolysin. PubMed: Families of metalloendopeptidases and their relationships. PubMed: Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development. PubMed: Structure of astacin and implications for activation of astacins and zinc-ligation of collagenases. PubMed: The alpha subunit of meprin A. Molecular cloning and sequencing, differential expression in inbred mouse strains, and evidence for divergent evolution of the alpha and beta subunits. PubMed: The astacin family of metalloendopeptidases. PubMed: Kinetics of nitroanilide cleavage by astacin. PubMed: [Incidence of astacin in neonfish].