diethyl malate
malic acid, diethyl ester
Identification
| Name | diethyl malate |
| CAS Number | 7554-12-3 |
| EINECS | 231-444-5 |
| FDA UNII | 59W97T99HI |
| Molecular Formula | C8 H14 O5 |
| Molecular Weight | 190.19558000 |
| MDL Number | MFCD00048556 |
| Nikkaji Number | J44.123F |
| CoE Number | 382 |
Regulatory
| JECFA Food Flavoring | 620 diethyl malate |
| DG SANTE Food Flavourings | 09.439 diethyl malate |
| FEMA Number | 2374 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 7554-12-3 ; DIETHYL MALATE |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 99.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.12000 to 1.12800 @ 25.00 °C. |
| Pounds per Gallon - (est). | 9.320 to 9.386 |
| Refractive Index | 1.43600 to 1.44600 @ 20.00 °C. |
| Boiling Point | 254.00 °C. @ 760.00 mm Hg, 91.00 to 92.00 °C. @ 1.00 mm Hg |
| Vapor Pressure | 0.000410 mmHg @ 25.00 °C. (est) |
| Flash Point | 185.00 °F. TCC ( 85.00 °C. ) |
| logP (o/w) | 0.300 (est) |
| Soluble in | alcohol |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | perfuming agents |
Organoleptic Properties
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavoring agents and cosmetic fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for diethyl malate usage levels up to | 0.1000 % in the fragrance concentrate. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 3.70 (μg/capita/day) |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Sigma-Aldrich
Complete Supply Chain
The perfect blend of products and services that bring your creativity to life.
Synerzine, Inc.
Innovation. Customization. Aroma Ingredients.
Synerzine is a leading supplier of flavor and fragrance ingredients.
WholeChem, LLC
Connecting Innovators To the Building Blocks Of the Universe
Custom manufacturer and distributor of specialty ingredients. We make global local.
Potential Uses
Natural Occurrence
Synonyms
butanedioic acid, 2-hydroxy-, diethyl ester
butanedioic acid, hydroxy-, diethyl ester
butanedioic acid, hydroxy-, diethyl ester, (±)-
diethyl 2-hydroxy-1,4-butane dioate
diethyl 2-hydroxybutanedioate
diethyl DL-malate
diethyl hydroxybutane dioate
diethyl hydroxybutanedioate
diethyl-2-hydroxybutandioat
ethyl malate
hydroxybutane dioic acid diethyl ester
malic acid diethyl ester
malic acid, diethyl ester
PubMed:
Investigation for antimicrobial resistance modulating activity of diethyl malate and 1-methyl malate against beta-lactamase class A from Bacillus licheniformis by molecular dynamics, in vitro and in vivo studies.
PubMed:
Role of glutathione in lung retention of 99mTc-hexamethylpropyleneamine oxime in two unique rat models of hyperoxic lung injury.
PubMed:
Effectiveness of high-throughput miniaturized sorbent- and solid phase microextraction techniques combined with gas chromatography-mass spectrometry analysis for a rapid screening of volatile and semi-volatile composition of wines--a comparative study.
PubMed:
Acidic sphingomyelinase induced by electrophiles promotes proinflammatory cytokine production in human bladder carcinoma ECV-304 cells.
PubMed:
Acute depletion of reduced glutathione causes extensive carbonylation of rat brain proteins.
PubMed:
Cadmium-induced astroglial death proceeds via glutathione depletion.
PubMed:
Na-K-ATPase in rat cerebellar granule cells is redox sensitive.
PubMed:
Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.
PubMed:
Altered differentiation in rat and rabbit limb bud micromass cultures by glutathione modulating agents.
PubMed:
Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis.
PubMed:
Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway.
PubMed:
Determination of 5-hydroperoxyeicosatetraenoic acid produced in rat basophilic leukemia cell line RBL-2H3 by high-performance liquid chromatography with chemiluminescence detection.
PubMed:
Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase.
PubMed:
Mechanisms involved in aggravation of ethanol-induced gastric mucosal lesions in adrenalectomized rats.
PubMed:
Glutathione protects against exogenous oxidant injury to rabbit renal proximal tubules.
PubMed:
Association of substrates with alpha-chymotrypsin, diethyl alpha-acetoxysuccinate, and diethyl malate.