pangamic acid
vitamin B15
Identification
| Name | pangamic acid |
| IUPAC | (2R,3S,4R,5R)-6-[2,2-bis[di(propan-2-yl)amino]acetyl]oxy-2,3,4,5-tetrahydroxyhexanoic acid |
| CAS Number | 13149-69-4 |
| EINECS | 236-088-4 |
| FDA UNII | Search |
| Molecular Formula | C10 H19 N O8 |
| Molecular Weight | 281.26203000 |
| Nikkaji Number | J317.836F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1e+006 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for pangamic acid usage levels up to | not for fragrance use. |
| Recommendation for pangamic acid flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
(2R,3S,4R,5R)-6-[2,2-bis[
di(propan-2-yl)amino]acetyl]oxy-2,3,4,5-tetrahydroxyhexanoic acid
dimethyl-amino-acetyl gluconic acid
D-
gluconic acid, 6-(bis(1-methylethyl)amino)acetate)
D-
gluconic acid, 6-ester with N,N-dimethylglycine
6-(bis(bis(iso
propyl)amino)acetate)-D-gluconic acid
vitamin B15
PubMed:
Communication and education for families dealing with end-of-life decisions.
PubMed:
A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance - part 28.
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Studies on the chemical identity and biological functions of pangamic acid.
PubMed:
[Chemotherapy of destructive pulmonary tuberculosis with antioxidants and antihypoxic agents].
PubMed:
[The nutritional prevention of postradiation effects].
PubMed:
[Effects of administration of vitamin A, B 2 and B 15 to guinea pigs during the larval stage of ascariasis on alpha-amylase activity in the lungs and kidneys].
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[The prevention of neurotoxic reactions during the treatment of pulmonary tuberculosis in middle-aged and elderly patients].
PubMed:
Examination of toxicity of diisopropylammonium dichloracetate (DADA), remedies for cardiac diseases, toward isolated rat hepatocytes.
PubMed:
[Pringle's adenoma of the sebaceous glands combined with vitiligo and logoneurosis].
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The effect of long-term enrichment of diet with selenium, vitamin E and B15 on the activity of certain enzymes in rat brain.
PubMed:
[The effect of pangamic acid on the course of larval ascariasis and riboflavin levels in the liver of guinea pigs].
PubMed:
[Combined focal scleroderma with generalized myasthenia].
PubMed:
[Bile secretion in chronic cholecystitis patients undergoing intragastric oxygen therapy combined with vitamin B15].
PubMed:
The effect of vitamin and mineral supplements and health foods on physical endurance and performance.
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[Oxygen therapy in the complex treatment of patients with chronic cholecystitis associated with reactive hepatitis].
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[Differential treatment children who have sustained closed craniocerebral injuries].
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Effect of long-term diet enrichment with selenium, vitamin E and vitamin B15 on the degree of fatty infiltration of the liver.
PubMed:
[Existence of "pangamic acid" alias "vitamin B 15"?].
PubMed:
[Effect of pangamic acid on the course of larval ascariasis and vitamin C concentrations in the adrenal glands and liver of guinea pigs].
PubMed:
[Effect of calcium pangamate on the cholesterol index of atherogenicity in cerebral arteriosclerosis patients].
PubMed:
[Autopsy of a phantom: pangamic acid, alias vitamin B15].
PubMed:
Pangamic acid, a stamina building, antistress and anti-hyperlipidemic principle from Cicer arietinum L.
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[Effect of vitamin B15 on cholesterol levels in the intestinal wall of rabbits].
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Effects of commercial preparations of pangamic acid (B15) on exercised rats.
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[Effect of oxygen therapy on liver functional indices in chronic cholecystitis].
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The effect of pangamic acid on maximal treadmill performance.
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Critical evaluation of the current studies on pangamic acid--vitamin B15.
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Mutagenicity of diisopropylamine dichloroacetate, the "active constituent" of vitamin B15 (pangamic acid).
PubMed:
Vitamins and cancer prevention: issues and dilemmas.
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[Effect of calcium pangamate on catecholamine metabolism in rheumatoid arthritis patients].
PubMed:
[Reflections on some vitamins and a modern vitaminology].
PubMed:
[Effect of orotic acid, calcium pangamate, and lipamide on ultrastructural changes in lipocytes in hepatic dystrophy].
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Effects of pangamic acid (B-15) ingestion on metabolic response to exercise.
PubMed:
[Effect of methionine and vitamins B12 and B15 on the content and distribution of proteins, glycogen and lipids in the hepatic lobules of chickens].
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FDA's hands loosely tied.
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Vitamin B15--whatever it is, it won't help.
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Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15").
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Mutagenicity of dimethylglycine when mixed with nitrite: possible significance in human use of pangamates.
PubMed:
From those wonderful people who brought you laetrile.
PubMed:
[Pathogenesis and treatment of rosacea and perioral dermatitis].
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Vitamin B15.
PubMed:
Pangamic acid ("vitamin B15").
PubMed:
The effects of vitamin B15 on contraction of striated muscle.
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FDA notes lack of evidence on pangamic acid claims.
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[Vitamin B15 and oxygen treatment of chronic cholecystocholangitis].
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Pangamic acid ('vitamin B15'). A review.
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Alpha adrenergic blocking effect exerted by vitamin B15.
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[Use of pangamic acid in hyperlipidemia].
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The application of ferrihydroxamic complexes to photocolorimetric determination of drugs. Part 2: Quantitative determination of calcium pangamate (vitamin B15) and its calcium gluconate mixtures.
PubMed:
[Effect of pangamic acid (Calgam) in type II hyperlipidemia].
PubMed:
[Vitamin B15 as a choleretic agent].
PubMed:
[Some biochemical indices of the clinical course of infectious hepatitis (Botkin's disease) in children and the effect of vitamin B15].
PubMed:
[Effect of pangamic acid (vitamin B 15) on the functional state of the thyroid gland of rats during a dietary deficiency of iodine].
PubMed:
Participation of pangamic acid (vitamin B 15 ) in synthesis of methyl group of methionine and biosynthesis of corrinoids.
PubMed:
[Effect of vitamin B15 on the excretion of vanilylamygdalic acid and catecholamines in cardiac ischemia].
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[Effect of pangamic acid (vitamin B15) during starvation].
PubMed:
[Effect of vitamin B15 on blood serum transaminases in experimental disease of the liver].
PubMed:
[Present state of research on pangamic acid (Vitamin B 15)].
PubMed:
[Experience with the use of pangamic acid (vitamin B-15) in arteriosclerosis of the vessels of the brain with mental disorders].
PubMed:
[Effect of pangamic acid on oxidative phosphorylation in skeletal muscle mitochondria].
PubMed:
[Effect of galascorbin and pangamic acid on activity of oxidative enzymes of liver mitochondria of rats in experimental toxic hepatitis].
PubMed:
[Pangamic acid in migraine].
PubMed:
[Distribution of injected pangamic acid (vitamin B 15) in the organism and its effect on oxidative metabolism of the brain].
PubMed:
[Effect of galascorbin and pangamic acid on some indices of energy metabolism of mitochondria of livers from rats with experimental toxic hepatitis].
PubMed:
[Mechanism of the effect of physical work on cholesterol metabolism. Effect of prolonged administration of pangamic acid (vitamin B 15) on muscle chemism].
PubMed:
[Effect of pangamic acid on biochemical changes in the blood and tissues of aging organisms during muscular exertion and rest].
PubMed:
[Vitamin B15 therapy in diabetes mellitus].
PubMed:
Partial characterization of synthetic pangamic acid vitamin B 15.
PubMed:
[Effect of pangamic acid on experimental myocarditis in rabbits].
PubMed:
[The effect of vitamin B15 on the cholinesterase-acetylcholine system in exudative diathesis].
PubMed:
[The effect of diisopropyl-ammonium dichloroacetate--a pangamic acid synthetic analogue (vitamin B 15)--on some metabolic indices in experimental toxic chronic hepatitis].
PubMed:
[Pangamic acid--vitamin B 15 (clinical review)].
PubMed:
[The effect of pangamic acid, methionine and of combinations of calcium gluconate and glycine on biochemical changes in the blood of sportsmen performing physical exercises].
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The effect of pangamic acid on fatty liver in experimental alcohol intoxication.
PubMed:
[Effect of pangamic acid (vitamin B 15) on the efficiency of experimental training].
PubMed:
[An analysis of the effect of pangamic acid on lipid metabolism during muscular efforts].
PubMed:
[Experiences with the use of vitamin B15 in the treatment of certain diseases of the liver].
PubMed:
Pangamic acid (vitamin B 15, pangametin, sopangamine): Its composition and determination in pharmaceutical dosage forms.
PubMed:
[An analysis of the influence exerted by pangamic acid (vitamin B 15) on the carbohydrate-phosphorus metabolism in muscle activity].
PubMed:
[Vitamin B15 and B13 in the treatment of some skin diseases].
PubMed:
[Pangamic acid in migraine].
PubMed:
[Effect of pangamic acid, methionine and a mixture of gluconate and glycine on the metabolism in the myocardium and on the ECG during muscular activity].
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PREVENTIVE EFFECT OF VITAMIN B15 IN EXPERIMENTAL FATTY INFILTRATION OF LIVER.
PubMed:
[Psoriasis and pangamic acid (vitamin B-15)].
PubMed:
[Pangamic acid (vitamin B-15), its nature, properties and production].
PubMed:
[Pangamic acid or vitamin B-15].
PubMed:
Some pharmacologic properties of pangamic acid (vitamin B-15).
PubMed:
Transmethylation in cardiopathies: the role of pangamic acid (vitamin B15).
PubMed:
A clinical study and evaluation on pangamic acid.
PubMed:
[Dichloroacetate of diisopropylammonium as molecule responsible for several pharmacological activities attributed to the so-called pangamic acid].
PubMed:
[Clinical applications of vitamin B15 or pangamic acid].
PubMed:
[The supposed methylating action of pangamic acid (so-called vitamin B15)].
PubMed:
[Pangamic acid or vitamin B15; physiological and therapeutic properties].
PubMed:
[Comparative clinical evaluation of the effects of the hypothetical octamethyl pangamic acid & dichloroethanoate of diisopropylammonium in dermatological pathology].
PubMed:
[Vitamin B15 (pangamic acid)].
PubMed:
[Analysis of commercial samples of vitamin B15].
PubMed:
[Clinical research on pangamic acid].
PubMed:
[Effects of pangamic acid in persons with cerebral sclerotic vascular disease].
PubMed:
[Pangamic acid in human therapy; pangamic acid and chronic liver diseases].
PubMed:
[Clinical evaluation of cardiotrophic effect of a new salt of pangamic acid].
PubMed:
[Pharmacological notes on pangamic acid].
PubMed:
[Pangamic acid in cerebral damages induced by sclerotic vasculopathy].
PubMed:
[Adrenal stimulation by pangamic acid and salicylic acid administered in association].
PubMed:
[Effect of pangamic acid on various tests of antirheumatic activity].
PubMed:
[Pharmacology and therapeutic role of a new biocatalase; pangamic acid or vitamin B15].
PubMed:
Preliminary observations in the treatment of cyanide poisoning with pangametin (vitamin B15).
PubMed:
Preliminary observations on the therapeutic effects of pangametin (vitamin B15).
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The effect of administration of synthetic vitamin B15 H8 upon creatine formation in the rat.
PubMed:
Pangamic acid (Vitamin B15) in heart disease; preliminary report of ten cases.
PubMed:
Pangamic acid sodium: a newly isolated crystalline water-soluble factor; a preliminary report.