Identification

Namevanillyl ethyl ether
IUPAC4-(ethoxymethyl)-2-methoxyphenol
CAS Number13184-86-6
EINECS236-136-4
FDA UNII1423UFT5P6
Molecular FormulaC10 H14 O3
Molecular Weight182.21918000
MDL NumberMFCD06409999
Nikkaji NumberJ213.731C
XlogP30.90 (est)

Regulatory

JECFA Food Flavoring887 vanillyl ethyl ether
DG SANTE Food Flavourings04.094 ethyl 4-hydroxy-3-methoxybenzyl ether
FEMA Number3815
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)13184-86-6 ; VANILLYL ETHYL ETHER

Physical Properties

Appearance pale yellow to amber yellow clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.10600 to 1.11300 @ 25.00 °C.
Pounds per Gallon - (est). 9.203 to 9.261
Refractive Index 1.52800 to 1.53200 @ 20.00 °C.
Boiling Point 212.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.003000 mmHg @ 25.00 °C. (est)
Flash Point 248.00 °F. TCC ( 120.00 °C. )
logP (o/w) 1.571 (est)
Soluble in alcohol

Organoleptic Properties

Odor Strength medium
Substantivity > 400 hour(s) at 20.00 % in ethyl alcohol
Odor Description
at 20.00 % in ethyl alcohol.
alcoholic rum sweet chocolate creamy vanilla spicy nutmeg smoky
Odor sample from Alfrebro LLC/ Archer Daniels Midland Company
Taste Description
sweet rummy chocolate creamy vanilla
sweet rummy chocolate creamy vanilla

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 > 2000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for vanillyl ethyl ether usage levels up to0.6000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)20.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)22.00 (μg/capita/day)
baked goods5.00000
beverages(nonalcoholic)30.00000
beverages(alcoholic)30.00000
breakfast cereal5.00000
cheese-
chewing gum200.00000
condiments / relishes-
confectionery froastings100.00000
egg products-
fats / oils-
fish products-
frozen dairy3.00000
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy100.00000
imitation dairy-
instant coffee / tea3.00000
jams / jellies-
meat products-
milk products20.00000
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods50.00000
soft candy100.00000
soups-
sugar substitutes-
sweet sauces-

Alfrebro LLC/ Archer Daniels Midland Company

Let's get reacquainted

Building great taste with aroma chemicals, extracts, and distillates

View All Website 513-539-7373 sforbis@alfrebro.com

Axxence Aromatic GmbH

We bring nature to your flavour

Dedicated to provide the best possible quality and supply service of natural aroma ingredients.

View All Website +49.2822.68561.0 service@axxence.com

Beijing Lys Chemicals Co, LTD.

From Grams to Tons

Fine chemical high-tech company which contains R&D, production, and sales.

View All Website 86-10-68418738 jiayanyong@lyschem.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Charkit Chemical Corporation

The Specialty Chemical Specialists

Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.

View All Website 203-299-3220 sales@charkit.com

Excellentia International

Ingredients by Nature

Exceptional quality and excellence in meeting our customers requirements.

View All Website 732.749.9840 info@excellentiaint.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Tianjin Danjun International Trade Co., LTD.

Quality Products

We know the Chinese chemical market well.

View All Website +86-15822601686 songshasha@danjunchem.com

WholeChem, LLC

Connecting Innovators To the Building Blocks Of the Universe

Custom manufacturer and distributor of specialty ingredients. We make global local.

View All Website +1 (262) 995.8668 info@wholechem.com

Potential Uses

FR amber FL smoke FR vanilla FR woody

Natural Occurrence

vanilla bean wine

Synonyms

p- cresol, a-ethoxy-2-methoxy- alpha- ethoxy-2-methoxy-p-cresol alpha- ethoxy-2-methoxy-para-cresol 4-( ethoxymethyl)-2-methoxyphenol ethyl 4-hydroxy-3-methoxybenzyl ether ethyl vanillyl ether 4- hydroxy-3-methoxybenzyl ethyl ether phenol, 4-(ethoxymethyl)-2-methoxy- vanillin ethyl ether US Patents: 4,657,700 - Fragrance compositions containing benzyl ethers PubMed: [Chemical constituents from tubers of Cremastra appendiculata]. PubMed: [Chemical constituents of Cudrania cochinchinensis]. PubMed: [Phenolic derivatives from Wisteria sinensis sweet caulis]. PubMed: Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera. PubMed: Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera. PubMed: A study on anticancer activity of Caulis Spatholobi extract on human osteosarcoma Saos-2 cells. PubMed: Biodegradation of 2,4-dichlorophenol by shiitake mushroom (Lentinula edodes) using vanillin as an activator. PubMed: [Chemical constituents from aqueous extract of Gastrodia elata]. PubMed: Effects of glucam P-20, vanillin, and fixolide on mosquito repellency of citronella oil lotions. PubMed: Simultaneous determination of five active compounds in chimonanthus nitens by double-development HPTLC and scanning densitometry. PubMed: Lignin structural variation in hardwood species. PubMed: Triacylglyceride measurement in small quantities of homogenised insect tissue: comparisons and caveats. PubMed: Artificial aging of Uva di Troia and Primitivo wines using oak chips inoculated with Penicillium purpurogenum. PubMed: Identification of DypB from Rhodococcus jostii RHA1 as a lignin peroxidase. PubMed: Improved iterative synthesis of linearly disassembling dendrons. PubMed: Physicochemical, nutritional, and functional characterization of fruits xoconostle (Opuntia matudae) pears from Central-México Region. PubMed: Total synthesis of (+)-schweinfurthins B and E. PubMed: A rapid and precise method for determination of D/H ratios of plant methoxyl groups. PubMed: [Studies on the chemical constituents of Litsea lancifolia]. PubMed: Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. PubMed: Oxidation of lignin using aqueous polyoxometalates in the presence of alcohols. PubMed: Evaluation of a Hypocrea jecorina enzyme preparation for hydrolysis of Tifton 85 bermudagrass. PubMed: Vanillin, 4-hydroxybenzyl aldehyde and 4-hydroxybenzyl alcohol prevent hippocampal CA1 cell death following global ischemia. PubMed: Protective effects of several components of Gastrodia elata on lipid peroxidation in gerbil brain homogenates. PubMed: [Chemical constituents from roots of Ardisia punctata]. PubMed: In vitro androgenicity in pulp and paper mill effluents. PubMed: The effects of sample preparation and gas chromatograph injection techniques on the accuracy of measuring guaiacol, 4-methylguaiacol and other volatile oak compounds in oak extracts by stable isotope dilution analyses. PubMed: Application of solid-phase extraction for determination of phenolic compounds in barrique wines. PubMed: Guaiacylglycerol-7'-O-methyl 8'-vanillic acid ether and related compounds from Boreava orientalis. PubMed: Chemical analysis and antifungal activity of the essential oil of Calea clematidea. PubMed: Maturing wines in oak barrels. Effects of origin, volume, and age of the barrel on the wine volatile composition. PubMed: Production of oxychemicals from precipitated hardwood lignin. PubMed: Formation and Degradation of Furfuryl Alcohol, 5-Methylfurfuryl Alcohol, Vanillyl Alcohol, and Their Ethyl Ethers in Barrel-Aged Wines. PubMed: Inhibition of oxidation of human low-density lipoproteins by phenolic substances in different essential oils varieties. PubMed: Network of C-H...O interactions in 4-benzyloxy-3-methoxybenzaldehyde (vanillin benzyl ether). PubMed: Characterization of the key aroma compounds in dried fruits of the West African peppertree Xylopia aethiopica (Dunal) A. Rich (Annonaceae) using aroma extract dilution analysis. PubMed: Concentrations of salinomycin in eggs and tissues of laying chickens fed medicated feed for 14 days followed by withdrawal for 3 days. PubMed: Oxidation of phenolic arylglycerol beta-aryl ether lignin model compounds by manganese peroxidase from Phanerochaete chrysosporium: oxidative cleavage of an alpha-carbonyl model compound. PubMed: Degradation of non-phenolic beta-o-4 lignin substructure model compounds by Acinetobacter sp. PubMed: Devil's-claw (Proboscidea louisianica), essential oil and its components : Potential allelochemical agents on cotton and wheat. PubMed: Thiol-mediated oxidation of nonphenolic lignin model compounds by manganese peroxidase of Phanerochaete chrysosporium. PubMed: Isolation and characterization of an anaerobic dehydrodivanillin-degrading bacterium. PubMed: [Simultaneous analysis of aromatic aldehydes and coumarins with high pressure liquid chromatography. Application to wines and brandies stored in oak barrels]. PubMed: Anaerobic degradation of veratrylglycerol-beta-guaiacyl ether and guaiacoxyacetic acid by mixed rumen bacteria. PubMed: Alarm substances of the stingless bee,Trigona silvestriana. PubMed: Catabolism of arylglycerol-beta-aryl ethers lignin model compounds by Pseudomonas cepacia 122. PubMed: Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus. PubMed: Biosynthesis, deposition, and partial characterization of potato suberin phenolics. PubMed: Gas-chromatographic estimation of 3-methoxy-4-hydroxy phenylglycol after transformation to vanillin methoxime trimethylsilyl ether. PubMed: Gas-chromatographic estimation of urinary vanillylmandelic acid after transformation to vanillin methoxime trimethylsilyl ether. PubMed: [Benzoins, benzils and benzilic acids of o-vanillin- and o-novovanillin ether].