ivalin
2,8-dihydroxyeudesma-4(14),11(13)-dien-12-oic acid gamma-lactone
Identification
| Name | ivalin |
| IUPAC | (3aR,4aS,7S,8aR,9aR)-7-hydroxy-8a-methyl-3,5-dimethylidene-3a,4,4a,6,7,8,9,9a-octahydrobenzo[f][1]benzofuran-2-one |
| CAS Number | 5938-03-4 |
| FDA UNII | Search |
| Molecular Formula | C15 H20 O3 |
| Molecular Weight | 248.32200000 |
| Nikkaji Number | J12.745K |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 416.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 350.00 °F. TCC ( 176.90 °C. ) (est) |
| logP (o/w) | 1.740 (est) |
| Soluble in | water, 2205 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ivalin usage levels up to | not for fragrance use. |
| Recommendation for ivalin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2,8-
dihydroxyeudesma-4(14),11(13)-dien-12-oic acid gamma-lactone
eudesma-4(14),11(13)-dien-12-oic acid, 2,8-dihydroxy-, gamma-lactone
(3aR,4aS,7S,8aR,9aR)-7-
hydroxy-8a-methyl-3,5-dimethylidene-3a,4,4a,6,7,8,9,9a-octahydrobenzo[f][1]benzofuran-2-one
PubMed:
Sesquiterpenes from an Egyptian herbal medicine, Pulicaria undulate, with inhibitory effects on nitric oxide production in RAW264.7 macrophage cells.
PubMed:
Phytochemical constituents of Carpesium macrocephalum F(R). et S(AV).
PubMed:
Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones.
PubMed:
Cytotoxic sesquiterpene lactones from Carpesium abrotanoides.
PubMed:
2D 1H and 13C NMR evidence for stereoselective formation of a new bond C-N, C-S or C-C in the reaction of ivalin acetate with substituted pyrimidines.
PubMed:
The influence of the sesquiterpene lactones from Geigeria on mast cell degranulation.
PubMed:
The effect of the sesquiterpene lactones from Geigeria on glycolytic enzymes.
PubMed:
Sesquiterpenlactone aus Arnica chamissonis IV.1,2 Ivalin und andere Sesquiterpenlactone aus den Blütenkörbchen der Subspecies genuina.
PubMed:
Influence of phomopsin and ivalin on steroid-hormone binding and growth of MCF-7 human breast cancer cells.
PubMed:
Steroid hormone-receptor activity in the presence of a mycotoxic phomopsin toxin and the sesquiterpene ivalin toxin.