prephenic acid

1-(2- carboxy-2-oxoethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic acid 1- carboxy-4-hydroxy-2,5-cyclohexadiene-1-pyruvic acid 2,5- cyclohexadiene-1-propanoic acid, 1-carboxy-4-hydroxy-alpha-oxo- PubMed: Steered Molecular Dynamics Methods Applied to Enzyme Mechanism and Energetics. PubMed: Screening of Satureja subspicata Vis. Honey by HPLC-DAD, GC-FID/MS and UV/VIS: Prephenate Derivatives as Biomarkers. PubMed: Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis. PubMed: In vivo instability of chorismate causes substrate loss during fermentative production of aromatics. PubMed: Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. PubMed: Mapping enzymatic catalysis using the effective fragment molecular orbital method: towards all ab initio biochemistry. PubMed: Identification of a metagenome-derived prephenate dehydrogenase gene from an alkaline-polluted soil microorganism. PubMed: Interaction between DAHP synthase and chorismate mutase endows new regulation on DAHP synthase activity in Corynebacterium glutamicum. PubMed: Characterisation of volatile and non-volatile metabolites in etiolated leaves of tea (Camellia sinensis) plants in the dark. PubMed: Molecular dynamics simulation of the last step of a catalytic cycle: product release from the active site of the enzyme chorismate mutase from Mycobacterium tuberculosis. PubMed: Stereochemical outcome at four stereogenic centers during conversion of prephenate to tetrahydrotyrosine by BacABGF in the bacilysin pathway. PubMed: Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis. PubMed: Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. PubMed: An N-terminal protein degradation tag enables robust selection of highly active enzymes. PubMed: Crystal structure of prephenate dehydrogenase from Streptococcus mutans. PubMed: A "diels-alderase" at last. PubMed: Identification of genes in the phenylalanine metabolic pathway by ectopic expression of a MYB transcription factor in tomato fruit. PubMed: Complementation of the pha2 yeast mutant suggests functional differences for arogenate dehydratases from Arabidopsis thaliana. PubMed: Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. PubMed: Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis. PubMed: Mechanism and plasticity of isochorismate pyruvate lyase: a computational study. PubMed: Genetic and biochemical identification of the chorismate mutase from Corynebacterium glutamicum. PubMed: On-the-path random walk sampling for efficient optimization of minimum free-energy path. PubMed: Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases. PubMed: Computer-aided rational design of catalytic antibodies: The 1F7 case. PubMed: Vitamin K1 accumulation in tobacco plants overexpressing bacterial genes involved in the biosynthesis of salicylic acid. PubMed: Multiple-steering QM-MM calculation of the free energy profile in chorismate mutase. PubMed: Investigation of ligand binding and protein dynamics in Bacillus subtilis chorismate mutase by transverse relaxation optimized spectroscopy-nuclear magnetic resonance. PubMed: Differential transition-state stabilization in enzyme catalysis: quantum chemical analysis of interactions in the chorismate mutase reaction and prediction of the optimal catalytic field. PubMed: How an enzyme surmounts the activation energy barrier. PubMed: The near attack conformation approach to the study of the chorismate to prephenate reaction. PubMed: Just a near attack conformer for catalysis (chorismate to prephenate rearrangements in water, antibody, enzymes, and their mutants). PubMed: Investigation of solvent effects for the Claisen rearrangement of chorismate to prephenate: mechanistic interpretation via near attack conformations. PubMed: Comparison of formation of reactive conformers (NACs) for the Claisen rearrangement of chorismate to prephenate in water and in the E. coli mutase: the efficiency of the enzyme catalysis. PubMed: Efficiency of lignin biosynthesis: a quantitative analysis. PubMed: Understanding the role of active-site residues in chorismate mutase catalysis from molecular-dynamics simulations. PubMed: Mapping of chorismate mutase and prephenate dehydrogenase domains in the Escherichia coli T-protein. PubMed: The mechanism of catalysis of the chorismate to prephenate reaction by the Escherichia coli mutase enzyme. PubMed: HARO7 encodes chorismate mutase of the methylotrophic yeast Hansenula polymorpha and is derepressed upon methanol utilization. PubMed: Probing the catalytic mechanism of prephenate dehydratase by site-directed mutagenesis of the Escherichia coli P-protein dehydratase domain. PubMed: Identifying groups involved in the binding of prephenate to prephenate dehydrogenase from Escherichia coli. PubMed: New insight into the catalytic mechanism of chorismate mutases from structural studies. PubMed: Monofunctional chorismate mutase from Bacillus subtilis: FTIR studies and the mechanism of action of the enzyme. PubMed: 13C NMR studies of the enzyme-product complex of Bacillus subtilis chorismate mutase. PubMed: Monofunctional chorismate mutase from Serratia rubidaea: a paradigm system for the three-isozyme gene family of enteric bacteria. PubMed: Remnants of an ancient pathway to L-phenylalanine and L-tyrosine in enteric bacteria: evolutionary implications and biotechnological impact. PubMed: A single cyclohexadienyl dehydrogenase specifies the prephenate dehydrogenase and arogenate dehydrogenase components of the dual pathways to L-tyrosine in Pseudomonas aeruginosa. PubMed: Monofunctional chorismate mutase from Bacillus subtilis: kinetic and 13C NMR studies on the interactions of the enzyme with its ligands. PubMed: Catalysis of concerted reactions by antibodies: the Claisen rearrangement. PubMed: Synthesis of bacilysin by Bacillus subtilis branches from prephenate of the aromatic amino acid pathway. PubMed: A simple spectrophotometric assay for arogenate dehydratase. PubMed: Purification of chorismate, prephenate, and arogenate by HPLC. PubMed: The postprephenate biochemical pathways to phenylalanine and tyrosine: an overview. PubMed: Tyrosine biosynthesis in Sorghum bicolor: isolation and regulatory properties of arogenate dehydrogenase. PubMed: Incorporation of chorismic acid and 4-aminobenzoic acid into the 4-hydroxyaniline moiety of N-(gamma-L-glutamyl)-4-hydroxyaniline in Agaricus bisporus. PubMed: Mechanisms of enzymatic and acid-catalyzed decarboxylations of prephenate. PubMed: Biosynthesis of ketomycin. PubMed: Secondary tritium isotope effects as probes of the enzymic and nonenzymic conversion of chorismate to prephenate. PubMed: Co-accumulation of prephenate, L-arogenate, and spiro-arogenate in a mutant of Neurospora. PubMed: Isolation and structure determination of a novel spiro-gamma-lactam, spiro-arogenate. PubMed: [Biosynthesis of phenylalanine and tyrosine in Streptomycetes]. PubMed: Synthesis and separation of tritium-labeled intermediates of the shikimate pathway. PubMed: Chorismate mutase-prephenate dehydrogenase from Escherichia coli. Kinetic mechanism of the prephenate dehydrogenase reaction. PubMed: Conversion of phenylalanine into tyrosine by portulaca callus. PubMed: Regulation of tyrosine biosynthesis by phenylalanine in anthramycin-producing Streptomyces refuineus. PubMed: A novel method for purification of prephenic acid. PubMed: Allosteric enzyme-tRNA complexes as regulators of transcription or translation. PubMed: Aromatic amino acid biosynthesis in Alcaligenes eutrophus H16. II. The isolation and characterization of mutants auxotrophic for phenylalanine and tyrosine. PubMed: THE BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE; ENZYMES CONVERTING CHORISMIC ACID INTO PREPHENIC ACID AND THEIR RELATIONSHIPS TO PREPHENATE DEHYDRATASE AND PREPHENATE DEHYDROGENASE. PubMed: PREPARATION OF PREPHENIC ACID AND ITS CONVERSION TO PHENYLALANINE AND TYROSINE BY PLANT ENZYMES. PubMed: Aromatic biosynthesis. XVI. Aromatization of prephenic acid to p-hydroxyphenylpyruvic acid, a step in tyrosine biosynthesis in Escherichia coli. PubMed: Isolation of prephenic acid from Neurospora.