cohumulone
5-(alpha,beta-dibromophenethyl)-5-methylhydantoin
Identification
| Name | cohumulone |
| IUPAC | 3,5,6-trihydroxy-4,6-bis(3-methylbut-2-enyl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one |
| CAS Number | 511-25-1 |
| FDA UNII | 2Y34G4NIC8 |
| Molecular Formula | C20 H28 O5 |
| Molecular Weight | 348.43916000 |
| Nikkaji Number | J22.573H |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 6.681 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cohumulone usage levels up to | not for fragrance use. |
| Recommendation for cohumulone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2,5-
cyclohexadien-1-one, 3,4,5-trihydroxy-2-isobutyryl-4,6-bis(3-methyl-2-butenyl)-
5-(alpha,beta-
dibromophenethyl)-5-methylhydantoin
3,4,5-
trihydroxy-2-isobutyryl-4,6-bis(3-methyl-2-butenyl)-2,5-cyclohexadien-1-one
3,5,6-
trihydroxy-4,6-bis(3-methylbut-2-enyl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one
PubMed:
Fast Sampling, Analyses and Chemometrics for Plant Breeding: Bitter Acids, Xanthohumol and Terpenes in Lupulin Glands of Hops (Humulus lupulus).
PubMed:
Vibrational spectroscopy and chemometrics for rapid, quantitative analysis of bitter acids in hops (Humulus lupulus).
PubMed:
Hyperforin and deoxycohumulone as a larvicidal agent against Culex pipiens (Diptera: Culicidae).
PubMed:
Simultaneous determination of prenylflavonoid and hop bitter acid in beer lee by HPLC-DAD-MS.
PubMed:
Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro.
PubMed:
[Analysis of six acidic components in hops extracts by high performance liquid chromatography].
PubMed:
Prenylated acylphloroglucinol derivatives: isoprenomics-based design, syntheses and antioxidative activities.
PubMed:
Evaluation of genetic variability of wild hops (Humulus lupulus L.) in Canada and the Caucasus region by chemical and molecular methods.
PubMed:
18O stable isotope labeling, quantitative model experiments, and molecular dynamics simulation studies on the trans-specific degradation of the bitter tasting iso-alpha-acids of beer.
PubMed:
Deodorant effects of a supercritical hops extract: antibacterial activity against Corynebacterium xerosis and Staphylococcus epidermidis and efficacy testing of a hops/zinc ricinoleate stick in humans through the sensory evaluation of axillary deodorancy.
PubMed:
Effect of HLA DQ2, dietary exposure and coeliac disease on the development of antibody response to gliadin in children.
PubMed:
Biosynthetic experiments with tall plants under field conditions. 18O2 incorporation into humulone from Humulus lupulus.
PubMed:
Comparative chemical attributes of native North American hop, Humulus lupulus var. lupuloides E. Small.
PubMed:
An improved NMR method for the quantification of alpha-acids in hops and hop products.