2,4-hexadienal
hexa-2,4-dienal
Identification
| Name | 2,4-hexadienal |
| CAS Number | 80466-34-8 |
| FDA UNII | Search |
| Molecular Formula | C6 H8 O |
| Molecular Weight | 96.12896000 |
Regulatory
Physical Properties
| Appearance | pale yellow to yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 155.86 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 2.970000 mmHg @ 25.00 °C. (est) |
| Flash Point | 143.00 °F. TCC ( 61.70 °C. ) (est) |
| logP (o/w) | 1.381 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Organoleptic Properties
| Odor Strength | high , |
| Substantivity | > 1 hour(s) at 100.00 % |
| Odor Description |
at 1.00 % in dipropylene glycol. Fatty, sweet, green aldehydic odor with a spicy finish
|
| Taste Description |
green creamy Sweet, green, creamy
|
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavoring agents |
| IFRA Critical Effect | Insufficient data |
| Recommendation for 2,4-hexadienal usage levels up to | PROHIBITED: Should not be used as a fragrance ingredient. |
Bedoukian Research, Inc.
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Potential Uses
Natural Occurrence
Synonyms
hexa-2,4-dienal
2,4-
hexadien-1-al
PubMed:
Comprehensive analysis of the catalytic and structural properties of a mu-class glutathione s-transferase from Fasciola gigantica.
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Degradation of Diphenyl Ether in Sphingobium phenoxybenzoativorans SC_3 Is Initiated by a Novel Ring Cleavage Dioxygenase.
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Multi-trait analysis of post-harvest storage in rocket salad (Diplotaxis tenuifolia) links sensorial, volatile and nutritional data.
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PARTICIPATION OF Y89 AND Y97 IN THE CONJUGATING ACTIVITY OF Drosophila melanogaster GLUTATHIONE S-TRANSFERASE D3 (DmGSTD3).
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Use of TD-GC-TOF-MS to assess volatile composition during post-harvest storage in seven accessions of rocket salad (Eruca sativa).
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Change of volatile compounds in fresh fish meat during ice storage.
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exo-Selective asymmetric Diels-Alder reaction of 2,4-dienals and nitroalkenes by trienamine catalysis.
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Laboratory investigation on the role of organics in atmospheric nanoparticle growth.
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Volatile composition of four southern highbush blueberry cultivars and effect of growing location and harvest date.
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Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.
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The fate of benzene-oxide.
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Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels.
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Effect of soybean volatile compounds on Aspergillus flavus growth and aflatoxin production.
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A kinetic and mechanistic study of the amino acid catalyzed aldol condensation of acetaldehyde in aqueous and salt solutions.
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Characterization of Taenia solium cysticerci microsomal glutathione S-transferase activity.
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The atmospheric photolysis of E-2-hexenal, Z-3-hexenal and E,E-2,4-hexadienal.
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Volatile emissions from Aesculus hippocastanum induced by mining of larval stages of Cameraria ohridella influence oviposition by conspecific females.
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Metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4.
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Syntheses of (-)-TAN-2483A, (-)-massarilactone B, and the fusidilactone B ring system. Revision of the structures of and syntheses of (+/-)-Waol A (FD-211) and (+/-)-Waol B (FD-212).
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Purification, characterization and kinetic properties of the Taenia solium glutathione S-transferase isoform 26.5 kDa.
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NTP toxicology and carcinogensis Studies of 2,4-hexadienal (89% trans,trans isomer, CAS No. 142-83-6; 11% cis,trans isomer) (Gavage Studies).
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Volatile constituents from the leaves of Callicarpa japonica Thunb. and their antibacterial activities.
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Particle growth by acid-catalyzed heterogeneous reactions of organic carbonyls on preexisting aerosols.
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Alpha,beta-unsaturated carbonyl compounds: induction of oxidative DNA damage in mammalian cells.
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Forestomach tumor induction by 2,4-hexadienal in F344N rats and B6C3F1 mice.
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Synthesis of (-)-TAN-2483A. Revision of the structures and syntheses of (+/-)-FD-211 (waol A) and (+/-)-FD-212 (waol B).
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Short term feeding of hexadienal to postnatal rats: effects on stomach aldehyde dehydrogenase.
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Thresholds of carcinogenicity of flavors.
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Identification of aroma compounds in Parmigiano-Reggiano cheese by gas chromatography/olfactometry.
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The influence of the solvents DMSO and ethanol on the genotoxicity of alpha,beta-unsaturated aldehydes in the SOS chromotest.
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Glutathione S-transferase pi expression in forestomach carcinogenesis process induced by gavage-administered 2,4-hexadienal in the F344 rat.
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DNA-damaging potential and glutathione depletion of 2-cyclohexene-1-one in mammalian cells, compared to food relevant 2-alkenals.
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Structure-activity relationships in the induction of DNA-protein cross-links by hematotoxic ring-opened benzene metabolites and related compounds in HL60 cells.
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Appearance of cross linked proteins in human atheroma and rat pre-fibrotic liver detected by a new monoclonal antibody.
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Reactive ring-opened aldehyde metabolites in benzene hematotoxicity.
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Neighboring Group Effects in Intramolecular Aldol Condensations. Rate Enhancement by gamma Substituents(1).
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Chemistry and antimicrobial activity of caryoynencins analogs.
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Iron-stimulated ring-opening of benzene in a mouse liver microsomal system. Mechanistic studies and formation of a new metabolite.
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The hematotoxic effects of 6-hydroxy-trans,trans-2,4-hexadienal, a reactive metabolite of trans,trans-muconaldehyde, in CD-1 mice.
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Interaction of trans,trans-muconaldehyde with bovine serum albumin.
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Mutagenicity of trans,trans-muconaldehyde and its metabolites in V79 cells.
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Reaction of (E,E)-muconaldehyde and its aldehydic metabolites, (E,E)-6-oxohexadienoic acid and (E,E)-6-hydroxyhexa-2,4-dienal, with glutathione.
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Identification and characterization of deoxyguanosine adducts of mutagenic beta-alkyl-substituted acrolein congeners.
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Pathways of trans,trans-muconaldehyde metabolism in mouse liver cytosol: reversibility of monoreductive metabolism and formation of end products.
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Cell spreading on collagen that has been exposed to reactive aldehydes.
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Mutagenicity of beta-alkyl substituted acrolein congeners in the Salmonella typhimurium strain TA100 and genotoxicity testing in the SOS chromotest.
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Pseudo malonaldehyde activity in the thiobarbituric acid test.