valerenic acid

(2E)-3-[(4S,7R,7aR)-3,7- dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylacrylic acid (2E)-3-[(4S,7R,7aR)-3,7- dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid (E)-3-[(4S,7R,7aR)-3,7- dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl]-2-methylprop-2-enoic acid (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a- hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid (4S-(4alpha(E),7beta,7aalpha))-3-(2,4,5,6,7,7a- hexahydro-3,7-dimethyl-1H-inden-4-yl)-2-methyl-2-propenoic acid 2- propenoic acid, 3-[(4S,7R,7aR)-2,4,5,6,7,7a-hexahydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-, (2E)- valerenicacid valerinic acid PubMed: Esters of valerenic acid as potential prodrugs. PubMed: Revised structures of nardal and nardin: identity with valerenal and valerenic acid. PubMed: Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. PubMed: Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansii in comparison to Valeriana officinalis. PubMed: Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. PubMed: Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity. PubMed: Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors. PubMed: Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). PubMed: Pharmacokinetics of valerenic acid in rats after intravenous and oral administrations. PubMed: Efficient and scalable one-pot synthesis of 2,4-dienols from cycloalkenones: optimized total synthesis of valerenic acid. PubMed: Three phases hollow fiber LPME combined with HPLC-UV for extraction, preconcentration and determination of valerenic acid in Valeriana officinalis. PubMed: Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes. PubMed: Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice. PubMed: Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women. PubMed: Concise synthesis of Valerena-4,7(11)-diene, a highly active sedative, from valerenic acid. PubMed: Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. PubMed: Highly potent modulation of GABA(A) receptors by valerenic acid derivatives. PubMed: Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. PubMed: Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L. PubMed: Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle. PubMed: Total synthesis of valerenic acid, a potent GABAA receptor modulator. PubMed: Hepatic metabolism and biliary excretion of valerenic acid in isolated perfused rat livers: role of Mrp2 (Abcc2). PubMed: Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier. PubMed: GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. PubMed: HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes. PubMed: [Studies on chemical constituents of Valeriana officinalis]. PubMed: Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation. PubMed: Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. PubMed: [GC-MS analysis of volatile constituents from five different kinds of Chinese eaglewood]. PubMed: Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity. PubMed: Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro. PubMed: NF-kappaB modulators from Valeriana officinalis. PubMed: Commercial valerian interactions with [3H]Flunitrazepam and [3H]MK-801 binding to rat synaptic membranes. PubMed: Chemical fingerprinting of valeriana species: simultaneous determination of valerenic acids, flavonoids, and phenylpropanoids using liquid chromatography with ultraviolet detection. PubMed: Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. PubMed: Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. PubMed: Extraction of valerenic acids from valerian (Valeriana officinalis L.) rhizomes. PubMed: In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. PubMed: Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. PubMed: Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. PubMed: Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. PubMed: Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. PubMed: The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. PubMed: In vitro release of valerenic and hydroxyvalerenic acids from valerian tablets. PubMed: (-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis. PubMed: Valepotriates and valerenic acids in commercial preparations of valerian available in Australia. PubMed: Analysis of sesquiterpenes in Valeriana officinalis by capillary electrophoresis. PubMed: Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia. PubMed: Valerenic acid derivatives and valepotriates among individuals, varieties and species of Valeriana. PubMed: The scientific basis for the reputed activity of Valerian. PubMed: Cytotoxic potential of valerian constituents and valerian tinctures. PubMed: Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines. PubMed: In vitro study on the interaction of Valeriana officinalis L. extracts and their amino acids on GABAA receptor in rat brain. PubMed: Central nervous depressant activity of valerenic Acid in the mouse. PubMed: Central nervous depressant activity of valerenic acid in the mouse. PubMed: [Inhibition of gamma-aminobutyric acid catabolism by valerenic acid derivatives].