phenyl butyrate

phenyl butanoate

CAS: 4346-18-3 C10 H12 O2 MW: 164.20404000

Identification

Namephenyl butyrate
CAS Number4346-18-3
EINECS224-405-9
FDA UNIIR9K49A127H
Molecular FormulaC10 H12 O2
Molecular Weight164.20404000
Nikkaji NumberJ121.748H
XlogP32.70 (est)

Regulatory

JECFA Food Flavoring2019 phenyl butyrate
FEMA Number4621
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)4346-18-3 ; PHENYL BUTYRATE

Physical Properties

Appearance colorless to pale yellow clear liquid (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.03700 to 1.03900 @ 20.00 °C.
Pounds per Gallon - (est). 8.639 to 8.656
Boiling Point 225.00 to 226.00 °C. @ 760.00 mm Hg, 85.00 °C. @ 8.00 mm Hg
Vapor Pressure 0.065000 mmHg @ 25.00 °C. (est)
Flash Point 194.00 °F. TCC ( 90.00 °C. )
logP (o/w) 2.672 (est)
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description sweet floral

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for phenyl butyrate usage levels up tonot for fragrance use.
Structure ClassI
baked goods-
beverages(nonalcoholic)0.10000
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices0.20000
gelatins / puddings0.20000
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

butanoic acid phenyl ester butanoic acid, phenyl ester butanoic acid, phenylester butyrate phenyl butyric acid phenyl ester butyric acid, phenyl ester fragerol phenyl butanoate PubMed: Molecular diagnosis of urea cycle disorders: current global scenario. PubMed: Epigenetic changes during hematopoietic cell granulocytic differentiation--comparative analysis of primary CD34+ cells, KG1 myeloid cells and mature neutrophils. PubMed: GHB receptor targets in the CNS: focus on high-affinity binding sites. PubMed: Functional analysis and in vitro correction of splicing FAH mutations causing tyrosinemia type I. PubMed: Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations. PubMed: Susceptibility of hepatoma-derived cells to histone deacetylase inhibitors is associated with ID2 expression. PubMed: In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors. PubMed: Nickel-Catalyzed Cross-Coupling of Aryl Halides with Alkyl Halides: Ethyl 4-(4-(4-methylphenylsulfonamido)-phenyl)butanoate. PubMed: DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling. PubMed: Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells. PubMed: Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4. PubMed: Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells. PubMed: C/EBPα and PU.1 are involved in distinct differentiation responses of acute promyelocytic leukemia HL-60 and NB4 cells via chromatin remodeling. PubMed: Novel radioiodinated {gamma}-hydroxybutyric acid analogues for radiolabeling and Photolinking of high-affinity {gamma}-hydroxybutyric acid binding sites. PubMed: IL-1beta induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells. PubMed: Response of retinoic acid-resistant KG1 cells to combination of retinoic acid with diverse histone deacetylase inhibitors. PubMed: [Ornithine transcarbamylase deficiency in adolescence and adulthood: first manifestation with life-threatening decompensation]. PubMed: Lipid-induced ER stress: synergistic effects of sterols and saturated fatty acids. PubMed: Light induced functionalization of PCL-PEG block copolymers for the covalent immobilization of biomolecules. PubMed: Detection of metabolite changes in C6 glioma cells cultured with antimitotic oleyl glycoside by 1H MAS NMR. PubMed: Surface functionalization of a poly(butylene terephthalate) (PBT) melt-blown filtration membrane by wet chemistry and photo-grafting. PubMed: Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting. PubMed: Sodium phenyl butyrate downregulates endothelin-1 expression in cultured human endothelial cells: relevance to sickle-cell disease. PubMed: Effects of histone deacetylase inhibitors, sodium phenyl butyrate and vitamin B3, in combination with retinoic acid on granulocytic differentiation of human promyelocytic leukemia HL-60 cells. PubMed: [Phenol butyrate inhibits cell cycle of leukemia cell lines through up-regulation of p21WAF1/CIP1 gene]. PubMed: Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment. PubMed: Fetal haemoglobin augmentation in E/beta(0) thalassaemia: clinical and haematological outcome. PubMed: A practical molecular clip for immobilization of receptors and biomolecules on devices' surface: synthesis, grafting protocol and analytical assay. PubMed: Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia. PubMed: Pharmacological approaches to correcting the ion transport defect in cystic fibrosis. PubMed: [cDNA array in the establishment of a gene expression profile associated with differentiation inducing the glioma cells]. PubMed: Fc-receptor-mediated targeting of antibody-bearing liposomes containing dideoxycytidine triphosphate to human monocyte/macrophages. PubMed: In vitro and in vivo activity of 1-aryl-3-(2-chloroethyl) urea derivatives as new antineoplastic agents. PubMed: Haloketone transition state analog inhibitors of cholesterol esterase. PubMed: 1-Aryl-3-(2-chloroethyl) ureas: synthesis and in vitro assay as potential anticancer agents. PubMed: Further studies on the antineoplastic activity of homo-aza-steroidal esters. PubMed: Identity of purified monoacylglycerol lipase, palmitoyl-CoA hydrolase and aspirin-metabolizing carboxylesterase from rat liver microsomal fractions. A comparative study with enzymes purified in different laboratories. PubMed: New compounds: antitumor activity of 3beta-hydroxy-13alpha-amino-13,17-seco-5alpha-androstan-17-oic-13,17-lactam 4-[p-[bis(2-chloroethyl)amino]phenyl]butyrate. PubMed: Carboxylesterases (EC 3.1.1). A comparison of some kinetic properties of horse, sheep, chicken, pig, and ox liver carboxylesterases. PubMed: Sterility in the Mexican Fruit Fly Caused by Chemicals. PubMed: Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation. PubMed: ER stress induced by the OCH1 mutation triggers changes in lipid homeostasis in Kluyveromyces lactis.