vernolide

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ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-

CAS: 17610-24-1 C17 H24 O MW: 244.37748000
All Ingredients Aromatic Ingredients CAS Numbers EINECS Numbers Fragrance Ingredients

Identification

Namevernolide
IUPAC1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethanone
CAS Number17610-24-1
EINECS241-585-4
FDA UNIISearch
Molecular FormulaC17 H24 O
Molecular Weight244.37748000
MDL Numberverdoxan
Nikkaji NumberJ287.087H

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 347.00 to 348.00 °C. @ 760.00 mm Hg (est)
Flash Point 295.00 °F. TCC ( 146.30 °C. ) (est)
logP (o/w) 4.527 (est)
Soluble in alcohol
Insoluble in water

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryfragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for vernolide flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)- 1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one 1-(3,5,5,8,8- pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethanone 1-(3,5,5,8,8- pentamethyl-6,7-dihydronaphthalen-2-yl)ethanone 1-(5,6,7,8- tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)ethan-1-one 1-(5,6,7,8- tetrahydro-3',5',5',8',8'-pentamethyl-2-naphthalenyl)-ethanone 5',6',7',8'- tetrahydro-3',5',5',8',8'-pentamethyl-2'-acetonaphthone PubMed: A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). PubMed: Modulation of cytotoxic T lymphocyte, natural killer cell, antibody-dependent cellular cytotoxicity, and antibody-dependent complement-mediated cytotoxicity by Vernonia cinerea L. and vernolide-A in BALB/c mice via enhanced production of cytokines IL-2 and IFN-γ. PubMed: Vernolide-A inhibits radiation-induced hypoxia-mediated tumor angiogenesis by regulating HIF-1α, MMP-2, MMP-9, and VEGF. PubMed: Antimetastatic potential of vernolide-A, a sesquiterpenoid from Vernonia cinerea L. PubMed: Vernolide-A, a sesquiterpene lactone from Vernonia cinerea, induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation. PubMed: Vernolide-A inhibits tumour specific angiogenesis by regulating proinflammatory cytokines, VEGF, MMPs and TIMP. PubMed: Effect of vernolide-A, a sesquiterpene lactone from Vernonia cinerea L., on cell-mediated immune response in B16F-10 metastatic melanoma-bearing mice. PubMed: Antimalarial activity of sesquiterpene lactones from Vernonia cinerea. PubMed: Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina. PubMed: Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis. PubMed: Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. PubMed: Isolation and identification of antibacterial compounds from Vernonia colorata leaves. PubMed: Use of Vernonia amygdalina by wild chimpanzee: possible roles of its bitter and related constituents.