hydrocortisone acetate

21-(acetyl oxy)-11,17-pregn-4-ene-3,20-dione

CAS: 50-03-3 C23 H32 O6 MW: 404.50324000

Identification

Namehydrocortisone acetate
CAS Number50-03-3
EINECS200-004-4
FDA UNII3X7931PO74
Molecular FormulaC23 H32 O6
Molecular Weight404.50324000
MDL NumberMFCD00037714
Nikkaji NumberJ4.096G
Beilstein2066841
XlogP32.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 223.00 °C. @ 760.00 mm Hg
Boiling Point 576.56 °C. @ 760.00 mm Hg (est)
Flash Point 385.00 °F. TCC ( 196.20 °C. ) (est)
logP (o/w) 2.190
Soluble in water, 38.71 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 2300 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 45050 ug/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for hydrocortisone acetate usage levels up tonot for fragrance use.
Recommendation for hydrocortisone acetate flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

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Penta International Corporation

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

ab bocort abbocort acepolcort-H acetate-AS aceto-cort 21-( acetyl oxy)-11,17-pregn-4-ene-3,20-dione 21-O- acetylcortisol alfacorton allocort bacicoline bambicort berlison biocortar caldecort carmol HC carmol-HC chemysone chloromycetin hydrocortisone ophthalmic clear-aid colifoam collusul-HC colofoam cortacream cortaid cortef acetate cortell cortes corti crema transcutan crematranscutan derminovag dermosa hidrocortisona [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17- dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate dricort efcolin efcorlin efzem ekzemsalbe F epifoam fenitral fernisone glycocortison hemsol-HC hipokort hycor eye oitment hycortole acetate hyderm hydrin-2 hydrison hydrocal 17a- hydrocorticosterone-21-acetate hydrocortisat hydrocortison hydrocortisone 21-acetate hydrocortistab hydrocortole acetate hydrocortone acetate hydrosone 17- hydroxycorticosterone 21-acetate 17-a- hydroxycorticosterone 21-acetate hydroxycorticosterone acetate 17-a- hydroxycorticosterone acetate 17- hydroxycorticosterone, 21-acetate hysone-A idrocort iracetisone korti lanacort latimit lenirit lidaform-HC lidamantle-HC mantadil medithane micort-HC ophticor orabase HCA pabracort pannocort pregn-4-ene-3, 20-dione, 11b,17,21-trihydroxy-, 21-acetate pregn-4-ene-3, 20-dione, 21- (acetyloxy)-11,17-dihydroxy-, (11b)- pregn-4-ene-3,20-dione, 11-b,17,21-trihydroxy-, 21-acetate pregn-4-ene-3,20-dione, 11b,17,21-trihydroxy-, 21-acetate pregn-4-ene-3,20-dione, 21-(acetoxy)-11,17-dihydroxy-, (11-b)- iso pto-hydrocortisone resicort sagittacortin sanadermil sigma cort sigmacort siguent hycor sintotrat soenol hydrocortison squibb-HC supralef urecortyn velopural wycort PubMed: [Detection of glucocorticoids by pressurized capillary electrochromatography with ultra-violet detection and its application in hair analysis]. PubMed: Comparison of HPLC and multivariate regression methods for hydrocortisone and lidocaine analysis of pharmaceutical preparations. PubMed: Food restriction-like effects of dehydroepiandrosterone: decreased lymphocyte numbers and functions with increased apoptosis. PubMed: Pulmonary pathohistological changes in mice in experimental infection with Pneumocystis carinii. PubMed: Influence of hydrocortisone acetate of the longissimus dorsi muscle during gestation of rats. PubMed: Influence of gestation and hydrocortisone-acetate treatment on the nutritive utilization of protein. PubMed: Effect of cortisol on some nutritional and biochemical parameters in pregnant rats and their foetuses. PubMed: Effects of hydrocortisone acetate and estradiol in normal and adrenalectomized salt deficient rabbits.