hexylene glycol

1,3,3-trimethyl-1,3-propanediol

CAS: 107-41-5 C6 H14 O2 MW: 118.17598000

Identification

Namehexylene glycol
IUPAC2-methylpentane-2,4-diol
CAS Number107-41-5
EINECS203-489-0
FDA UNIIKEH0A3F75J
Molecular FormulaC6 H14 O2
Molecular Weight118.17598000
MDL NumberMFCD00004547
Nikkaji NumberJ3.614E
Beilstein1098298

Regulatory

FDA Mainterm (IAUFC)107-41-5 ; HEXYLENE GLYCOL

Physical Properties

Appearance colorless clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.92400 @ 25.00 °C.
Melting Point -40.00 °C. @ 760.00 mm Hg
Boiling Point 197.00 to 199.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.096000 mmHg @ 25.00 °C. (est)
Vapor Density 4.1 ( Air = 1 )
Flash Point > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w) 0.004 (est)
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength none
Substantivity 400 Hour(s)
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3700 mg/kg
Dermal Toxicityskin-rabbit LD50 8560 ul/kg
Inhalation Toxicityinhalation-rat LC50 > 310 mg/m3/1H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic ingredient for skin and hair care
Recommendation for hexylene glycol usage levels up tonot for fragrance use.
Recommendation for hexylene glycol flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Charkit Chemical Corporation

The Specialty Chemical Specialists

Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.

View All Website 203-299-3220 sales@charkit.com

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

Innovation and commitment in the name of excellence.

View All Website +39 039.685.6262

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Potential Uses

blender emulsifying agents skin conditioning solvents surfactants

Natural Occurrence

can be nature identical

Synonyms

2,4- dihydroxy-2-methyl pentane 2,4- dihydroxy-2-methylpentane 1,3- dimethyl-3-hydroxybutanol diolane hexylen glycol (±)- hexylene glycol isol 2- methyl pentane-2,4-diol 2- methyl-2,4-pentandiol 4- methyl-2,4-pentane diol 2- methyl-2,4-pentanediol 2- methylpentane-2,4-diol 2,4- pentanediol, 2-methyl- pinakon 1,1,3- trimethyl trimethylene diol alpha,alpha,alpha'- trimethyl trimethylene glycol 1,1,3- trimethyl-1,3-propanediol 1,3,3- trimethyl-1,3-propanediol 1,1,3- trimethyltrimethylenediol PubMed: Refolding of SDS-denatured proteins using amphipathic cosolvents and osmolytes. PubMed: Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Thermus thermophilus HB8. PubMed: Crystal structure of silkworm Bombyx mori JHBP in complex with 2-methyl-2,4-pentanediol: plasticity of JH-binding pocket and ligand-induced conformational change of the second cavity in JHBP. PubMed: Nanolitre-scale crystallization using acoustic liquid-transfer technology. PubMed: Sequence-dependent effects of cryoprotectants on the active sites of the human ABO(H) blood group A and B glycosyltransferases. PubMed: Structure-property relationship in new photo-cured dimethacrylate-based dental resins. PubMed: A strategy for purifying glutathione S-transferase in the presence of sodium dodecyl sulfate. PubMed: Atomic force microscopy imaging of human metaphase chromosomes in liquid. PubMed: The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. PubMed: 2-Methyl-2,4-pentanediol induces spontaneous assembly of staphylococcal α-hemolysin into heptameric pore structure. PubMed: Diffusion in ternary aqueous systems containing human serum albumin and precipitants of different classes. PubMed: Properties of a new mouthrinse for patients receiving radiation therapy. PubMed: PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler. PubMed: Formulation of creams with betamethasone dipropionate: evaluation of chemical stability. PubMed: Contact urticaria with systemic symptoms due to hexylene glycol in a topical corticosteroid: case report and review of hypersensitivity to glycols. PubMed: Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution. PubMed: Protecting role of cosolvents in protein denaturation by SDS: a structural study. PubMed: Efficient low-power heteronuclear decoupling in 13C high-resolution solid-state NMR under fast magic angle spinning. PubMed: Refolding SDS-denatured proteins by the addition of amphipathic cosolvents. PubMed: High-resolution solid-state MAS NMR of proteins-Crh as an example. PubMed: The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: a novel homodimer assembling and the implication for effector-binding mode. PubMed: Aqueous self-assembly of phytantriol in ternary systems: effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents. PubMed: Isolation of Arabidopsis nuclei and measurement of gene transcription rates using nuclear run-on assays. PubMed: A family of nanoporous materials based on an amino acid backbone. PubMed: Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. PubMed: Preferential hydration of DNA: the magnitude and distance dependence of alcohol and polyol interactions. PubMed: Effect of organic cosolvents on the free solution mobility of curved and normal DNA molecules. PubMed: Atomic force microscopy of native human metaphase chromosomes in a liquid. PubMed: Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium. PubMed: Pentane-1,5-diol as a percutaneous absorption enhancer. PubMed: Polar body formation in Spisula oocytes: function of the peripheral aster. PubMed: Induction of cytokinesis is independent of precisely regulated microtubule dynamics. PubMed: A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase. PubMed: Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. PubMed: Crystalization and preliminary X-ray crystallographic analysis of the laminarinase endo-beta-1,3-glucanase from Pyrococcus furiosus. PubMed: A redetermination of the structure of the triple mutant (K53,56,120M) of phospholipase A2 at 1.6 A resolution using sulfur-SAS at 1.54 A wavelength. PubMed: Exclusion of alcohols from spermidine-DNA assemblies: probing the physical basis of preferential hydration. PubMed: Characteristics of migration patterns of DNA oligomers in gels and the relationship to the question of intrinsic DNA bending. PubMed: Microtubule plus-end dynamics in Xenopus egg extract spindles. PubMed: The OH-initiated oxidation of hexylene glycol and diacetone alcohol. PubMed: Increased temperature and 2-methyl-2,4-pentanediol change the DNA structure of both curved and uncurved adenine/thymine-rich sequences. PubMed: Development of indomethacin Carbopol ETD 2001 gels and the influence of storage time and temperature on their stability. PubMed: The crystal structure and stereospecificity of levodione reductase from Corynebacterium aquaticum M-13. PubMed: Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2. PubMed: Influence of storage time and temperature on the stability of indomethacin Pluronic F-127 gels. PubMed: An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules. PubMed: Determination of glycols in biological specimens by gas chromatography-mass spectrometry. PubMed: Pluronic F-127 gels as a vehicle for topical formulations of indomethacin and rheological behaviour of these formulations. PubMed: KNI-272, a highly selective and potent peptidic HIV protease inhibitor. PubMed: The 1.19 A X-ray structure of 2'-O-Me(CGCGCG)(2) duplex shows dehydrated RNA with 2-methyl-2,4-pentanediol in the minor groove. PubMed: An open study of efficacy and safety of long-term treatment with mometasone furoate fatty cream in the treatment of adult patients with atopic dermatitis. PubMed: Crystallization, structure solution and refinement of hen egg-white lysozyme at pH 8.0 in the presence of MPD. PubMed: Bivariate flow cytometry DNA/BrdUrd analysis of plant cell cycle. PubMed: Crystallographic studies on a family B DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis strain KOD1. PubMed: Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure. PubMed: Non-flammable preparative reversed-phase liquid chromatography of recombinant human insulin-like growth factor-I. PubMed: Division of polar bodies induced by their enlargement in the starfish Asterina pectinifera. PubMed: Effects of neutral salts on RNA chain elongation and pausing by Escherichia coli RNA polymerase. PubMed: Effect of the crystallizing agent 2-methyl-2,4-pentanediol on the structure of adenine tract DNA in solution. PubMed: Comparison of the solution and crystal conformations of (G + C)-rich fragments of DNA. PubMed: The organic crystallizing agent 2-methyl-2,4-pentanediol reduces DNA curvature by means of structural changes in A-tracts. PubMed: Cosolvent-induced adsorption and desorption of serum proteins on an amphiphilic mercaptomethylene pyridine-derivatized agarose gel. PubMed: MPD and DNA bending in crystals and in solution. PubMed: What is the basis of sequence-directed curvature in DNAs containing A tracts? PubMed: Dehydrating agents sharply reduce curvature in DNAs containing A tracts. PubMed: Contribution of the surface free energy perturbation to protein-solvent interactions. PubMed: High resolution structures of the 4-4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity. PubMed: High resolution detection of uncoated metaphase chromosomes by means of field emission scanning electron microscopy. PubMed: Effect of hexylene glycol-altered microtubule distributions on cytokinesis and polar lobe formation in fertilized eggs of Ilyanassa obsoleta. PubMed: Cosolvent modulation of the tubulin-colchicine GTPase-activating conformational change: strength of the enzymatic activity. PubMed: Further evaluation of a new penetration enhancer, HPE-101. PubMed: The alpha-helical content of calmodulin is increased by solution conditions favouring protein crystallisation. PubMed: A high-yield procedure for isolation of metaphase chromosomes from root tips of Vicia faba L. PubMed: Conditions for assembly of tubulin-based structures in unfertilized sea urchin eggs. Spirals, monasters and cytasters. PubMed: The ultrastructure of Pityrosporum pachydermatis. PubMed: Preparation and flow cytometric analysis of metaphase chromosomes of tomato. PubMed: Change in the heterogeneous distribution of tubulin isotypes in mitotic microtubules of the sea urchin egg by treatment with microtubule depolymerizing or stabilizing drugs. PubMed: Antibacterial and antifungal properties of propylene glycol, hexylene glycol, and 1,3-butylene glycol in vitro. PubMed: Crystal structure of thioredoxin from Escherichia coli at 1.68 A resolution. PubMed: [Effect of hexylene glycol on microtubular structures in starfish oocytes and sea urchin eggs]. PubMed: Skin reactions to hexylene glycol. PubMed: Three-dimensional structure of a fluorescein-Fab complex crystallized in 2-methyl-2,4-pentanediol. PubMed: The genetic toxicology of some hydrocarbon and oxygenated solvents. PubMed: Differences in crystal properties and ligand affinities of an antifluorescyl Fab (4-4-20) in two solvent systems. PubMed: Phase diagrams for DNA crystallization systems. PubMed: [The use of phase diagrams in the crystallization of oligonucleotide duplexes. I. A model of crystallization of the (pGpT)n.(pApC)n + spermine system]. PubMed: Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F. PubMed: Cytoskeleton of the unfertilized sea urchin egg. PubMed: Oxygen consumption by tumor cells during membrane vesicle shedding. PubMed: Dual effect of procaine in sea urchin eggs. Inducer and inhibitor of microtubule assembly. PubMed: Effect of a nonsteroidal antiandrogen, flutamide, on androgen receptor dynamics and ornithine decarboxylase gene expression in mouse kidney. PubMed: Nuclear androgen receptors in different stages of the seminiferous epithelial cycle and the interstitial tissue of rat testis. PubMed: Nonaqueous fractionation of HeLa cells in glycols. PubMed: Composition of the isolated mitotic apparatus: analysis by polyacrylamide gel electrophoresis. PubMed: [Study of a lysis medium stabilizing microfilaments and microtubules in vitro and in vivo]. PubMed: Structure of variant-3 scorpion neurotoxin from Centruroides sculpturatus Ewing, refined at 1.8 A resolution. PubMed: Localization of estrogen receptor regulatory factor in the uterine nucleus. PubMed: Selective crystallization of horse isoferritins. PubMed: Chinese hamster metaphase chromosomes isolated under physiological conditions. A partial characterization of associated non-histone proteins and protein cores. PubMed: Possible role of microtubules in tumor cell surface membrane shedding, permeability, and lympholysis. PubMed: Preparation of calmodulin crystals. PubMed: Stereo electron microscope studies of mitotic chromosomes from Chinese hamster ovary cells. PubMed: Safety evaluation of some humectants and moisturizers used in cosmetic formulations. PubMed: Parthenogenetic activation of sea urchin egg induces a cyclical variation of the cytoplasmic resistance to hexylene glycol-Triton X-100 treatment. PubMed: Six polymorphic crystal forms of alpha-cobratoxin. PubMed: A new method for the preparation of metaphase chromosomes for flow analysis. PubMed: Packing DNA into chromosomes. PubMed: Experimental determinations of tubulin in the in vivo mitotic apparatus of sea urchin zygotes. PubMed: An analysis of spindle ultrastructure during prometaphase and metaphase of micronuclear division in Tetrahymena. PubMed: Induction of cleavage in nucleated and enucleated frog eggs by injection of isolated sea-urchin mitotic apparatus. PubMed: Studies on the de novo formation of centrioles: aster formation in the activated eggs of sea urchin. PubMed: Cytochemical and ultrastructural studies on the synaptonemal complex of rat spermatocytes. PubMed: Isolation of nuclei using hexylene glycol. PubMed: Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components. PubMed: The effect of vinblastine, colchicine and hexylene glycol on migration of human monocytes. PubMed: Spindle birefringence of isolated mitotic apparatus analysed by pressure treatment. PubMed: Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. II. Inhibition of antimicrotubular agents. PubMed: The avian erythrocyte: a study of fixation for electron microscopy. PubMed: Colchicine-binding protein and the secretion of thyroid hormone. PubMed: Electron probe analysis of freeze-substituted, epoxy resin embedded tissue for ion transport studies in plants. PubMed: Purification of intact microtubules from brain. PubMed: The mitotic apparatus. Physical chemical characterization of the 22S protein component and its subunits. PubMed: The mitotic apparatus. Identification of the major soluble component of the glycol-isolated mitotic apparatus. PubMed: The toxicity of 2-methylpentan-2, 4-diol (hexylene glycol) by chronic oral administration to rats and mice. PubMed: The excretion of hexylene glycol (2-methyl-2,4-pentane diol) in man. PubMed: Determination of 2-methyl-2,4-pentane diol (hexylene glycol) in the urine of man and rats. PubMed: Local and systemic effects of 2-methyl 2,4 pentanediol (hexylene glycol).