artesunate
artesunic acid
Identification
| Name | artesunate |
| CAS Number | 88495-63-0 |
| FDA UNII | 60W3249T9M |
| Molecular Formula | C19 H28 O8 |
| Molecular Weight | 384.42576000 |
| MDL Number | MFCD00866204 |
| Nikkaji Number | J258.545F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 507.12 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 3.200000 mmHg @ 25.00 °C. (est) |
| Flash Point | 348.00 °F. TCC ( 175.60 °C. ) (est) |
| logP (o/w) | 3.291 (est) |
| Soluble in | water, 56.25 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for artesunate usage levels up to | not for fragrance use. |
| Recommendation for artesunate flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Potential Uses
Natural Occurrence
Synonyms
arsumax
artesunatum
artesunic acid
butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-
decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-
decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate
dihydroartemisinine-12-alpha-succinate
dihydroqinghasu hemsuccinate
plasmotrim
plasmotrin
qinghaozhi
quinghaosu reduced succinate ester
succinyl dihydroartemisinin
1,5,9-
trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadec-10-yl propionicacid
4-oxo-4-{[(4S,5R,8S,9R,10S,12R,13R)-1,5,9-
trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadec-10-yl]oxy}butanoic acid
4-oxo-4-{[(1S,4S,5R,8S,9R,10S,12R,13R)-1,5,9-
trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy}butanoic acid
4-oxo-4-{[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-
trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid
4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-
trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-yl]oxy}butanoic acid
4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-
trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
PubMed:
Embryotoxicity and toxicokinetics of the antimalarial artesunate in rats.
PubMed:
Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial.
PubMed:
Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
PubMed:
Pharmacokinetic properties and bioequivalence of two sulfadoxine/pyrimethamine fixed-dose combination tablets: a parallel-design study in healthy Chinese male volunteers.
PubMed:
Management of imported malaria in Europe.
PubMed:
Pyronaridine-artesunate combination therapy for the treatment of malaria.
PubMed:
Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice.
PubMed:
Malaria: severe, life-threatening.
PubMed:
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production.
PubMed:
Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view.
PubMed:
Effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices in rats.
PubMed:
Intravenous artesunate for the treatment of severe malaria.
PubMed:
Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone.
PubMed:
Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.
PubMed:
Bioavailability of a co-formulated combination of amodiaquine and artesunate under fed and fasted conditions. A randomised, open-label crossover study.
PubMed:
Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon.
PubMed:
A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR - implications for therapeutic failure and drug resistance.
PubMed:
Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate.
PubMed:
Artemisinins and synthetic trioxolanes in the treatment of helminth infections.
PubMed:
[The treatment of falciparum malaria].
PubMed:
Malaria: severe, life-threatening.
PubMed:
Malaria: uncomplicated, caused by Plasmodium falciparum.
PubMed:
Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.
PubMed:
Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277).
PubMed:
Effect of artesunate and artemether against Clonorchis sinensis and Opisthorchis viverrini in rodent models.
PubMed:
Counterfeit and substandard antimalarial drugs in Cambodia.
PubMed:
Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria.
PubMed:
Artemisinin-based combination therapies for uncomplicated malaria.
PubMed:
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
PubMed:
Drugs. Reinventing an ancient cure for malaria.
PubMed:
Studies of the neurotoxicity of oral artemisinin derivatives in mice.
PubMed:
Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses.
PubMed:
Antiparasitic agents.
PubMed:
Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria.
PubMed:
Artemisinin enhances heme-catalysed oxidation of lipid membranes.
PubMed:
The iron environment in heme and heme-antimalarial complexes of pharmacological interest.
PubMed:
Antimalarial agents, 2. Artesunate, an inhibitor of cytochrome oxidase activity in Plasmodium berghei.