artesunate

artesunic acid

CAS: 88495-63-0 C19 H28 O8 MW: 384.42576000

Identification

Nameartesunate
CAS Number88495-63-0
FDA UNII60W3249T9M
Molecular FormulaC19 H28 O8
Molecular Weight384.42576000
MDL NumberMFCD00866204
Nikkaji NumberJ258.545F

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 507.12 °C. @ 760.00 mm Hg (est)
Vapor Pressure 3.200000 mmHg @ 25.00 °C. (est)
Flash Point 348.00 °F. TCC ( 175.60 °C. ) (est)
logP (o/w) 3.291 (est)
Soluble in water, 56.25 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for artesunate usage levels up tonot for fragrance use.
Recommendation for artesunate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

arsumax artesunatum artesunic acid butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester (3R,5aS,6R,8aS,9R,10S,12R,12aR)- decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate (3R,5aS,6R,8aS,9R,10S,12R,12aR)- decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate dihydroartemisinine-12-alpha-succinate dihydroqinghasu hemsuccinate plasmotrim plasmotrin qinghaozhi quinghaosu reduced succinate ester succinyl dihydroartemisinin 1,5,9- trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadec-10-yl propionicacid 4-oxo-4-{[(4S,5R,8S,9R,10S,12R,13R)-1,5,9- trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadec-10-yl]oxy}butanoic acid 4-oxo-4-{[(1S,4S,5R,8S,9R,10S,12R,13R)-1,5,9- trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy}butanoic acid 4-oxo-4-{[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9- trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid 4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9- trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-yl]oxy}butanoic acid 4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9- trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid PubMed: Embryotoxicity and toxicokinetics of the antimalarial artesunate in rats. PubMed: Efficacy of artesunate-amodiaquine and artemether-lumefantrine fixed-dose combinations for the treatment of uncomplicated Plasmodium falciparum malaria among children aged six to 59 months in Nimba County, Liberia: an open-label randomized non-inferiority trial. PubMed: Defining the timing of action of antimalarial drugs against Plasmodium falciparum. PubMed: Pharmacokinetic properties and bioequivalence of two sulfadoxine/pyrimethamine fixed-dose combination tablets: a parallel-design study in healthy Chinese male volunteers. PubMed: Management of imported malaria in Europe. PubMed: Pyronaridine-artesunate combination therapy for the treatment of malaria. PubMed: Genotoxicity assessment of the antimalarial compound artesunate in somatic cells of mice. PubMed: Malaria: severe, life-threatening. PubMed: Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. PubMed: Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view. PubMed: Effects of co-administration of artesunate and amodiaquine on some cardiovascular disease indices in rats. PubMed: Intravenous artesunate for the treatment of severe malaria. PubMed: Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone. PubMed: Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects. PubMed: Bioavailability of a co-formulated combination of amodiaquine and artesunate under fed and fasted conditions. A randomised, open-label crossover study. PubMed: Treatment of malaria from monotherapy to artemisinin-based combination therapy by health professionals in urban health facilities in Yaoundé, central province, Cameroon. PubMed: A stratified random survey of the proportion of poor quality oral artesunate sold at medicine outlets in the Lao PDR - implications for therapeutic failure and drug resistance. PubMed: Dynamic RNA profiling in Plasmodium falciparum synchronized blood stages exposed to lethal doses of artesunate. PubMed: Artemisinins and synthetic trioxolanes in the treatment of helminth infections. PubMed: [The treatment of falciparum malaria]. PubMed: Malaria: severe, life-threatening. PubMed: Malaria: uncomplicated, caused by Plasmodium falciparum. PubMed: Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia. PubMed: Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277). PubMed: Effect of artesunate and artemether against Clonorchis sinensis and Opisthorchis viverrini in rodent models. PubMed: Counterfeit and substandard antimalarial drugs in Cambodia. PubMed: Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria. PubMed: Artemisinin-based combination therapies for uncomplicated malaria. PubMed: Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues. PubMed: Drugs. Reinventing an ancient cure for malaria. PubMed: Studies of the neurotoxicity of oral artemisinin derivatives in mice. PubMed: Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses. PubMed: Antiparasitic agents. PubMed: Pharmacokinetics of mefloquine combined with artesunate in children with acute falciparum malaria. PubMed: Artemisinin enhances heme-catalysed oxidation of lipid membranes. PubMed: The iron environment in heme and heme-antimalarial complexes of pharmacological interest. PubMed: Antimalarial agents, 2. Artesunate, an inhibitor of cytochrome oxidase activity in Plasmodium berghei.