3,5,7,8,3',4'-hexahydroxyflavone-8-glucoside

CAS: 652-78-8 C21 H20 O13 MW: 480.38000000

Identification

Namegossypin
CAS Number652-78-8
FDA UNIIA3Q367XWX9
Molecular FormulaC21 H20 O13
Molecular Weight480.38000000
MDL NumberMFCD00017429
Nikkaji NumberJ94.552H
Beilstein0071526

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 229.00 to 230.00 °C. @ 760.00 mm Hg
Boiling Point 886.00 °C. @ 760.00 mm Hg (est)
Flash Point 591.00 °F. TCC ( 310.80 °C. ) (est)
logP (o/w) -1.320 (est)
Soluble in water, 4.391e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-guinea pig LD50 26300 ug/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for gossypin usage levels up tonot for fragrance use.
Recommendation for gossypin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

hibiscus vitifolious flowers

Synonyms

2-(3,4- dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one 2-(3,4- dihydroxyphenyl)-8-(beta-D-glucopyranosyloxy)-3,5,7-trihydroxy-4H-1-benzopyran-4-one 2-(3,4- dihydroxyphenyl)-8-(beta-dextro-glucopyranosyl oxy)-3,5,7-trihydroxy-4H-1-benzopyran-4-one gossypetin-8-glucoside 3,5,7,8,3',4'- hexahydroxyflavone-8-glucoside PubMed: Neuroprotective activity of gossypin from Hibiscus vitifolius against global cerebral ischemia model in rats. PubMed: Isolation of methyl 27-caffeoyloxyoleanolate--a new oleanane Triterpenoid from the roots of Hibiscus vitifolius. PubMed: Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. PubMed: Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. PubMed: Antidiabetic activity of gossypin, a pentahydroxyflavone glucoside, in streptozotocin-induced experimental diabetes in rats. PubMed: [Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase]. PubMed: Evaluation of anti-allergic activity of gossypin and suramin in mast cell-mediated allergy model. PubMed: Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats. PubMed: The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice. PubMed: Antiinflammatory and antinociceptive activities of gossypin and procumbentin--cyclooxygenase-2 (COX-2) inhibition studies. PubMed: Gossypin up-regulates LDL receptor through activation of ERK pathway: a signaling mechanism for the hypocholesterolemic effect. PubMed: Comparative evaluation of some flavonoids and tocopherol acetate against the systemic toxicity induced by sulphur mustard. PubMed: Influence of some bioflavonoids on the transport of nitrendipine. PubMed: A flavonoid gossypin binds to cyclin-dependent kinase 2. PubMed: Prophylactic effect of gossypin against percutaneously administered sulfur mustard. PubMed: Interaction of flavonoids and intestinal facilitated glucose transporters. PubMed: Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. PubMed: Gossypin protects primary cultured rat cortical cells from oxidative stress- and beta-amyloid-induced toxicity. PubMed: Free radical scavenging, antitumor and anticarcinogenic activity of gossypin. PubMed: Interaction of hydrated electron with dietary flavonoids and phenolic acids: rate constants and transient spectra studied by pulse radiolysis. PubMed: Influence of gossypin on the development of acute tolerance to morphine induced antinociception. PubMed: A study on the role of cholinergic and gamma amino butyric acid systems in the anti-nociceptive effect of gossypin. PubMed: Protective effects of phenolic compounds on CCl4-induced toxicity in isolated rat hepatocytes. PubMed: Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. PubMed: Dermal intoxication of mice with bis(2-chloroethyl)sulphide and the protective effect of flavonoids. PubMed: Possible development of dependence on gossypin: role of gossypin on morphine dependence. PubMed: Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. PubMed: Loss of plasmid linked antibiotic resistance in Escherichia coli on treatment with some phenolic compounds. PubMed: Anti-inflammatory and anti-allergic properties of flavonoids. PubMed: Studies on possible tolerance and mechanism of gossypin analgesia. PubMed: Flavonoid-induced delay in the small intestinal transit: possible mechanism of action. PubMed: Gossypin-induced analgesia in mice. PubMed: Effect of gossypin, a flavonoid, on the formation of galactose-induced cataracts in rats. PubMed: SOME OBSERVATIONS ON THE INFLUENCE OF RUTIN AND GOSSYPIN IN EXPERIMENTAL FROST-BITE.