norwogonin

5,7,8-trihydroxyflavone

CAS: 4443-09-8 C15 H10 O5 MW: 270.24070000

Identification

Namenorwogonin
CAS Number4443-09-8
FDA UNII70U0WT21IB
Molecular FormulaC15 H10 O5
Molecular Weight270.24070000
Nikkaji NumberJ126.069C
Beilstein0272168

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 528.40 °C. @ 760.00 mm Hg (est)
Flash Point 403.00 °F. TCC ( 206.00 °C. ) (est)
logP (o/w) 1.970 (est)
Soluble in water, 67.79 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for norwogonin usage levels up tonot for fragrance use.
Recommendation for norwogonin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

4H-1- benzopyran-4-one, 2-phenyl-5,7,8-trihydroxy- (9CI) 4H-1- benzopyran-4-one, 5,7,8-trihydroxy-2-phenyl- flavone, 5,7,8-trihydroxy- 2- phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one 5,7,8- trihydroxy-2-phenyl-4H-chromen-4-one 5,7,8- trihydroxy-2-phenylchromen-4-one 5,7,8- trihydroxyflavone PubMed: Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots. PubMed: Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii. PubMed: Suppressive effects of T-412, a flavone on interleukin-4 production in T cells. PubMed: Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone. PubMed: Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells. PubMed: Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages. PubMed: Studies on the constituents of roots of Scutellaria planipes. PubMed: The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis. PubMed: Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships. PubMed: Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids. PubMed: [Studies on the structures of new flavonoids from the root of Scutellaria amoena]. PubMed: Flavone mutagenicity in Salmonella typhimurium: dependence on the pKM101 plasmid and excision-repair deficiency. PubMed: Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships.