norwogonin
5,7,8-trihydroxyflavone
Identification
| Name | norwogonin |
| CAS Number | 4443-09-8 |
| FDA UNII | 70U0WT21IB |
| Molecular Formula | C15 H10 O5 |
| Molecular Weight | 270.24070000 |
| Nikkaji Number | J126.069C |
| Beilstein | 0272168 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 528.40 °C. @ 760.00 mm Hg (est) |
| Flash Point | 403.00 °F. TCC ( 206.00 °C. ) (est) |
| logP (o/w) | 1.970 (est) |
| Soluble in | water, 67.79 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for norwogonin usage levels up to | not for fragrance use. |
| Recommendation for norwogonin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 2-phenyl-5,7,8-trihydroxy- (9CI)
4H-1-
benzopyran-4-one, 5,7,8-trihydroxy-2-phenyl-
flavone, 5,7,8-trihydroxy-
2-
phenyl-5,7,8-trihydroxy-4H-1-benzopyran-4-one
5,7,8-
trihydroxy-2-phenyl-4H-chromen-4-one
5,7,8-
trihydroxy-2-phenylchromen-4-one
5,7,8-
trihydroxyflavone
PubMed:
Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots.
PubMed:
Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii.
PubMed:
Suppressive effects of T-412, a flavone on interleukin-4 production in T cells.
PubMed:
Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone.
PubMed:
Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells.
PubMed:
Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages.
PubMed:
Studies on the constituents of roots of Scutellaria planipes.
PubMed:
The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis.
PubMed:
Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships.
PubMed:
Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids.
PubMed:
[Studies on the structures of new flavonoids from the root of Scutellaria amoena].
PubMed:
Flavone mutagenicity in Salmonella typhimurium: dependence on the pKM101 plasmid and excision-repair deficiency.
PubMed:
Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships.