vanilmandelic acid
hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
Identification
| Name | vanilmandelic acid |
| CAS Number | 55-10-7 |
| EINECS | 200-224-0 |
| FDA UNII | 0DQI268449 |
| Molecular Formula | C9 H10 O5 |
| Molecular Weight | 198.17470000 |
| MDL Number | MFCD00004235 |
| Nikkaji Number | J27.583B |
| Beilstein | 2213227 |
| XlogP3 | -0.20 (est) |
Regulatory
| JECFA Food Flavoring | 2020 hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid |
| DG SANTE Food Flavourings | 08.134 4-hydroxy-3-methoxymandelic acid |
| FEMA Number | 4660 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 55-10-7 ; HYDROXY(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID |
Physical Properties
| Appearance | white to pale yellow powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 132.00 °C. @ 760.00 mm Hg |
| Boiling Point | 421.33 °C. @ 760.00 mm Hg (est) |
| Flash Point | 344.00 °F. TCC ( 173.33 °C. ) |
| logP (o/w) | -0.212 (est) |
| Shelf Life | 12.00 month(s) or longer if stored properly. |
| Storage | refrigerate in tightly sealed containers. |
| Soluble in | alcohol, slightly |
No sensory data available
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavoring agents |
| Recommendation for vanilmandelic acid usage levels up to | not for fragrance use. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 120.00 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 5000 (μg/person/day) |
| Threshold of Concern | 1800 (μg/person/day) |
| Structure Class | I |
| baked goods | 10.00000 |
| beverages(nonalcoholic) | 5.00000 |
| beverages(alcoholic) | 10.00000 |
| breakfast cereal | 10.00000 |
| cheese | - |
| chewing gum | 5.00000 |
| condiments / relishes | - |
| confectionery froastings | 10.00000 |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | 10.00000 |
| fruit ices | 10.00000 |
| gelatins / puddings | 20.00000 |
| granulated sugar | - |
| gravies | - |
| hard candy | 5.00000 |
| imitation dairy | 10.00000 |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | 10.00000 |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | 10.00000 |
| Dairy products, excluding products of category 02.0 (01.0) | 10.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | - |
| Edible ices, including sherbet and sorbet (03.0) | 10.00000 |
| Processed fruit (04.1) | - |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | 10.00000 |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | 10.00000 |
| Bakery wares (07.0) | 10.00000 |
| Meat and meat products, including poultry and game (08.0) | - |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | - |
| Eggs and egg products (10.0) | - |
| Sweeteners, including honey (11.0) | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | 10.00000 |
| Foodstuffs intended for particular nutritional uses (13.0) | - |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | 5.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | 10.00000 |
| Ready-to-eat savouries (15.0) | - |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | 20.00000 |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Potential Uses
Natural Occurrence
Synonyms
benzeneacetic acid, a,4-dihydroxy-3-methoxy-
alpha-4-
dihydroxy-3-methoxybenzeneacetic acid
4-
hydroxy 3-methoxymandelic acid
2-
hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
DL-4-
hydroxy-3-methoxy mandelic acid
4-
hydroxy-3-methoxy-DL-mandelic acid
(±)-4-
hydroxy-3-methoxymandelic acid
4-
hydroxy-3-methoxymandelic acid
dextro,laevo-4-
hydroxy-3-methoxymandelic acid
DL-4-
hydroxy-3-methoxymandelic acid
4-
hydroxy-3-methoxymandelicacid
4-
hydroxy-3-methoxyphenyl(hydroxy)acetic acid
(4-
hydroxy-3-methoxyphenyl) glycolic acid
(4-
hydroxy-3-methoxyphenyl)glycolic acid
hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
mandelic acid, 4-hydroxy-3-methoxy-
3-
methoxy-4-hydroxyphenylhydroxyacetic acid
nibovan
vanillinemandelic acid
vanillomandelic acid
vanillyl mandelic acid
vanillylmandelic acid
(±)-
vanillylmandelic acid
(±)-
vanilmandelic acid
PubMed:
Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial.
PubMed:
Evaluation of plasma 3,4-dihydroxyphenylacetic acid (DOPAC) and plasma 3,4-dihydroxyphenylalanine (DOPA) as tumor markers in children with neuroblastoma.
PubMed:
Increased urinary HVA levels in neuroblastoma screens related to diet, not tumor.
PubMed:
Energy expenditure during carbohydrate overfeeding in obese and nonobese adolescents.
PubMed:
Simultaneous determination of the major acidic metabolites of catecholamines and serotonin in urine by liquid chromatography with electrochemical detection after a one-step sample clean-up on Sephadex G-10; influence of vanilla and banana ingestion.
PubMed:
Diethylstilbestrol on urinary catecholamines and on food intake in castrated male rats.
PubMed:
[Circadian rhythm of 3-methoxy-4-hydroxymandelic acid and 3-methoxy-4-hydroxyphenylacetic acid in the urine].
PubMed:
Effects of diet on urinary excretion of MHPG in normal preadolescent boys.
PubMed:
Random one-hour urine catecholamine and 4-hydroxy-3-methoxymandelic acid assays for diagnosis of pheochromocytoma.
PubMed:
The effect of refeeding after semistarvation on catecholamine and thyroid metabolism.
PubMed:
Urinary excretion values in 2-day food-deprived, unrestrained chimpanzees.