cirsilineol

4',5-dihydroxy-3',6,7-trimethoxyflavone

CAS: 41365-32-6 C18 H16 O7 MW: 344.31992000

Identification

Namecirsilineol
IUPAC5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one
CAS Number41365-32-6
FDA UNII08DZZ529FE
Molecular FormulaC18 H16 O7
Molecular Weight344.31992000
MDL NumberMFCD01083015
Nikkaji NumberJ372.166C
Beilstein1355108

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 585.00 °C. @ 760.00 mm Hg (est)
Flash Point 419.00 °F. TCC ( 215.20 °C. ) (est)
logP (o/w) 1.670 (est)
Soluble in water, 45.53 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for cirsilineol usage levels up tonot for fragrance use.
Recommendation for cirsilineol flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

hyssop lippia citriodora sage plant tarragon plant thyme leaf

Synonyms

4H-1- benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy- cirsileneol 4',5- dihydroxy-3',6,7-trimethoxyflavone eupatrin 5- hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one 5- hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one PubMed: Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation. PubMed: Chemistry and biological activities of Tanacetum chiliophyllum var. oligocephalum extracts. PubMed: [Chemical constituents from twigs and leaves of Melodinus hemsleyanus]. PubMed: [Chemical constituents from twigs and leaves of Melodinus hemsleyanus]. PubMed: Artemisia herba alba: a popular plant with potential medicinal properties. PubMed: Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris. PubMed: Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation. PubMed: New terpenes from Salvia palaestina Benth. and Salvia syriaca L. growing wild in Jordan. PubMed: A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M. PubMed: Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats. PubMed: Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. PubMed: Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway. PubMed: Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita. PubMed: The anti-Helicobacter pylori flavones in a Brazilian plant, Hyptis fasciculata, and the activity of methoxyflavones. PubMed: [Study on chemical constituents in herbs of Anoectochilus roxburghii II]. PubMed: [Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC]. PubMed: Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity. PubMed: [Studies on chemical constituents in buds of Artemisia scoparia]. PubMed: [Determination of cirsilineol in Herba Artemisiae scopariae collected in autumn by HPLC]. PubMed: Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. PubMed: Protective effect of 4',5-dihydroxy-3',6,7-trimethoxyflavone from Artemisia asiatica against Abeta-induced oxidative stress in PC12 cells. PubMed: Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. PubMed: Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control. PubMed: Protective effects of some flavonoids on the renal cellular membrane. PubMed: Protein glycation inhibitors from thyme (Thymus vulgaris). PubMed: Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. PubMed: [Flavones isolated from Thymus carnosus Boiss].