cirsilineol
4',5-dihydroxy-3',6,7-trimethoxyflavone
Identification
| Name | cirsilineol |
| IUPAC | 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one |
| CAS Number | 41365-32-6 |
| FDA UNII | 08DZZ529FE |
| Molecular Formula | C18 H16 O7 |
| Molecular Weight | 344.31992000 |
| MDL Number | MFCD01083015 |
| Nikkaji Number | J372.166C |
| Beilstein | 1355108 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 585.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 419.00 °F. TCC ( 215.20 °C. ) (est) |
| logP (o/w) | 1.670 (est) |
| Soluble in | water, 45.53 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cirsilineol usage levels up to | not for fragrance use. |
| Recommendation for cirsilineol flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-
cirsileneol
4',5-
dihydroxy-3',6,7-trimethoxyflavone
eupatrin
5-
hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one
5-
hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxychromen-4-one
PubMed:
Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation.
PubMed:
Chemistry and biological activities of Tanacetum chiliophyllum var. oligocephalum extracts.
PubMed:
[Chemical constituents from twigs and leaves of Melodinus hemsleyanus].
PubMed:
[Chemical constituents from twigs and leaves of Melodinus hemsleyanus].
PubMed:
Artemisia herba alba: a popular plant with potential medicinal properties.
PubMed:
Potent α-glucosidase and protein tyrosine phosphatase 1B inhibitors from Artemisia capillaris.
PubMed:
Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.
PubMed:
New terpenes from Salvia palaestina Benth. and Salvia syriaca L. growing wild in Jordan.
PubMed:
A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.
PubMed:
Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats.
PubMed:
Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease.
PubMed:
Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway.
PubMed:
Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita.
PubMed:
The anti-Helicobacter pylori flavones in a Brazilian plant, Hyptis fasciculata, and the activity of methoxyflavones.
PubMed:
[Study on chemical constituents in herbs of Anoectochilus roxburghii II].
PubMed:
[Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC].
PubMed:
Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity.
PubMed:
[Studies on chemical constituents in buds of Artemisia scoparia].
PubMed:
[Determination of cirsilineol in Herba Artemisiae scopariae collected in autumn by HPLC].
PubMed:
Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.
PubMed:
Protective effect of 4',5-dihydroxy-3',6,7-trimethoxyflavone from Artemisia asiatica against Abeta-induced oxidative stress in PC12 cells.
PubMed:
Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.
PubMed:
Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control.
PubMed:
Protective effects of some flavonoids on the renal cellular membrane.
PubMed:
Protein glycation inhibitors from thyme (Thymus vulgaris).
PubMed:
Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures.
PubMed:
[Flavones isolated from Thymus carnosus Boiss].