hydnocarpin
5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one
Identification
| Name | hydnocarpin |
| IUPAC | 5,7-dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one |
| CAS Number | 51419-48-8 |
| FDA UNII | Search |
| Molecular Formula | C25 H20 O9 |
| Molecular Weight | 464.42720000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 740.00 to 741.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 496.00 °F. TCC ( 257.80 °C. ) (est) |
| logP (o/w) | 3.529 (est) |
| Soluble in | water, 22.32 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for hydnocarpin usage levels up to | not for fragrance use. |
| Recommendation for hydnocarpin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
5,7-
dihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chromen-4-one
PubMed:
[Chemical constituents from a Tibetan medicine Meconopsis horridula].
PubMed:
Hydnocarpus: an ethnopharmacological, phytochemical and pharmacological review.
PubMed:
[Study on chemical constituents of Callicarpa peii].
PubMed:
Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.
PubMed:
Potentiating effect of the flavonolignan (-)-hydnocarpin in combination with vincristine in a sensitive and P-gp-expressing acute lymphoblastic leukemia cell line.
PubMed:
[Chemical constituents from aerial parts of Fallopia dumetosum].
PubMed:
NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species.
PubMed:
Two new phenolic glycosides from Inula cappa.
PubMed:
[Chemical constituents from stems of Lonicera japonica].
PubMed:
Polyphenols isolated from antiradical extracts of Mallotus metcalfianus.
PubMed:
Bioactivity-guided isolation of cytotoxic constituents of Brucea javanica collected in Vietnam.
PubMed:
Free radical scavenging, enzyme inhibitory constituents from antidiabetic Ayurvedic medicinal plant Hydnocarpus wightiana Blume.
PubMed:
[Studies on chemical constituents of Meconopsis quintuplinervia Regel].
PubMed:
Staphylococcus aureus MDR efflux pump inhibitors from a Berberis and a Mahonia (sensu strictu) species.
PubMed:
Synthesis and structures of regioisomeric hydnocarpin-type flavonolignans.
PubMed:
Hypolipidemic, anti-inflammatory, and antineoplastic activity and cytotoxicity of flavonolignans isolated from Hydnocarpus wightiana seeds.