isosilybin

4H-1- benzopyran-4-one, 2-(2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy- 3,5,7- trihydroxy-2-[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one PubMed: Chemoenzymatic Synthesis, Characterization, and Scale-up of Milk Thistle Flavonolignan Glucuronides. PubMed: Synchronous microencapsulation of multiple components in silymarin into PLGA nanoparticles by an emulsification/solvent evaporation method. PubMed: Pyranone natural products as inspirations for catalytic reaction discovery and development. PubMed: Accumulation of silymarin in milk thistle seeds under drought stress. PubMed: A biomimetic strategy to access the silybins: total synthesis of (-)-isosilybin A. PubMed: The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. PubMed: Isolation and purification of diastereoisomeric flavonolignans from silymarin by binary-column recycling preparative high-performance liquid chromatography. PubMed: Simplified procedure of silymarin extraction from Silybum marianum L. Gaertner. PubMed: Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. PubMed: Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum). PubMed: Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II. PubMed: Mechanistic study of the biomimetic synthesis of flavonolignan diastereoisomers in milk thistle. PubMed: An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study. PubMed: A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors. PubMed: Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction. PubMed: HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case. PubMed: Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy. PubMed: Absolute configuration of isosilybin A by X-ray crystallography of the heavy atom analogue 7-(4-Bromobenzoyl)isosilybin A. PubMed: Absorption and metabolism of milk thistle flavanolignans in humans. PubMed: A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma. PubMed: Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling. PubMed: Pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro. PubMed: Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II). PubMed: Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage. PubMed: Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. PubMed: Enhanced production of silymarin by Ag+ elicitor in cell suspension cultures of Silybum marianum. PubMed: Identification of hepatoprotective flavonolignans from silymarin. PubMed: Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships. PubMed: Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. PubMed: Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum. PubMed: [Silymarin in the treatment of chronic liver diseases: past and future]. PubMed: Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin. PubMed: Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). PubMed: Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. PubMed: New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum. PubMed: Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. PubMed: Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention. PubMed: Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract. PubMed: Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin. PubMed: Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. PubMed: Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. PubMed: Anticancer potential of silymarin: from bench to bed side. PubMed: Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system. PubMed: Structure elucidation and antioxidant activity of (-)-isosilandrin isolated from Silybum marianum L. PubMed: Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry. PubMed: Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry. PubMed: Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. PubMed: Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. PubMed: Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, Isolated from Silybum marianum (milk thistle). PubMed: Analysis of the active components of silymarin. PubMed: Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum. PubMed: [Determination of the active flavonoids in silymarine]. PubMed: Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans. PubMed: Determination of active component in silymarin by RP-LC and LC/MS. PubMed: [Separation and determination of effective components in silymarin and preparations of silymarin by MECC]. PubMed: Flavonolignan production from Silybum marianum transformed and untransformed root cultures. PubMed: Comparative pharmacokinetics of silipide and silymarin in rats. PubMed: Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients. PubMed: Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. PubMed: [Structure of silandrin and silymonin, two new flavanolignans from a white blooming Silybum marianum variety].