silydianin
silidianin
Identification
| Name | silydianin |
| CAS Number | 29782-68-1 |
| EINECS | 249-848-5 |
| FDA UNII | 7P89L7W179 |
| Molecular Formula | C25 H22 O10 |
| Molecular Weight | 482.44234000 |
| MDL Number | MFCD09970974 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 481.9 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for silydianin usage levels up to | not for fragrance use. |
| Recommendation for silydianin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
silidianin
PubMed:
The study of flavonolignan association patterns in fruits of diverging Silybum marianum (L.) Gaertn. chemotypes provides new insights into the silymarin biosynthetic pathway.
PubMed:
Flavonolignans reduce the response of blood platelet to collagen.
PubMed:
Flavonolignans inhibit the arachidonic acid pathway in blood platelets.
PubMed:
The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.
PubMed:
Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells.
PubMed:
Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.
PubMed:
Effects of Potassium Sulfate [K2SO4] on The Element Contents, Polyphenol Content, Antioxidant and Antimicrobial Activities of Milk Thistle [Silybum Marianum].
PubMed:
Effects of Silymarin on Diabetes Mellitus Complications: A Review.
PubMed:
Flavonolignans inhibit ADP induced blood platelets activation and aggregation in whole blood.
PubMed:
A new approach to the rapid separation of isomeric compounds in a Silybum marianum extract using UHPLC core-shell column with F5 stationary phase.
PubMed:
Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived therefrom.
PubMed:
Silymarin content in Silybum marianum populations growing in Egypt.
PubMed:
Is Silybin the Best Free Radical Scavenger Compound in Silymarin?
PubMed:
Phototoxic potential of silymarin and its bioactive components.
PubMed:
Head-to-Head Comparison of Ultra-High-Performance Liquid Chromatography with Diode Array Detection versus Quantitative Nuclear Magnetic Resonance for the Quantitative Analysis of the Silymarin Complex in Silybum marianum Fruit Extracts.
PubMed:
Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.
PubMed:
Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.
PubMed:
Supercritical COâ extraction of oil, fatty acids and flavonolignans from milk thistle seeds: Evaluation of their antioxidant and cytotoxic activities in Caco-2 cells.
PubMed:
Synchronous microencapsulation of multiple components in silymarin into PLGA nanoparticles by an emulsification/solvent evaporation method.
PubMed:
Accumulation of silymarin in milk thistle seeds under drought stress.
PubMed:
Simplified procedure of silymarin extraction from Silybum marianum L. Gaertner.
PubMed:
Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II.
PubMed:
An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study.
PubMed:
An integrated proteomic approach to decipher the effect of methyl jasmonate elicitation on the proteome of Silybum marianum L. hairy roots.
PubMed:
Free Radical Scavenging and Antioxidant Activities of Silymarin Components.
PubMed:
Synchronized and controlled release of multiple components in silymarin achieved by the osmotic release strategy.
PubMed:
Absorption and metabolism of milk thistle flavanolignans in humans.
PubMed:
A sensitive LC-MS/MS assay for the simultaneous analysis of the major active components of silymarin in human plasma.
PubMed:
[Determination of active components in silymarin by UPLC-ESIMS].
PubMed:
Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study.
PubMed:
Pyrazinecarboxamides as potential elicitors of flavonolignan and flavonoid production in Silybum marianum and Ononis arvensis cultures in vitro.
PubMed:
Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage.
PubMed:
Rapid separation and characterization of active flavonolignans of Silybum marianum by ultra-performance liquid chromatography coupled with electrospray tandem mass spectrometry.
PubMed:
Enhanced production of silymarin by Ag+ elicitor in cell suspension cultures of Silybum marianum.
PubMed:
Milk thistle in liver diseases: past, present, future.
PubMed:
Topical delivery of silymarin constituents via the skin route.
PubMed:
Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum.
PubMed:
[Silymarin in the treatment of chronic liver diseases: past and future].
PubMed:
Drug-drug interactions of silymarin on the perspective of pharmacokinetics.
PubMed:
Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2).
PubMed:
Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
PubMed:
Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract.
PubMed:
Separation and characterization of active flavonolignans of Silybum marianum by liquid chromatography connected with hybrid ion-trap and time-of-flight mass spectrometry (LC-MS/IT-TOF).
PubMed:
Pretreatment of milk thistle seed to increase the silymarin yield: an alternative to petroleum ether defatting.
PubMed:
Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.
PubMed:
Anticancer potential of silymarin: from bench to bed side.
PubMed:
Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.
PubMed:
Synthesis and antihepatotoxic activity of some new chalcones containing 1, 4 - dioxane ring system.
PubMed:
Silymarin and its components scavenge phenylglyoxylic ketyl radicals.
PubMed:
Analysis and comparison of active constituents in commercial standardized silymarin extracts by liquid chromatography-electrospray ionization mass spectrometry.
PubMed:
Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.
PubMed:
Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication.
PubMed:
An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species.
PubMed:
Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.
PubMed:
A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
PubMed:
Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans.
PubMed:
Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).
PubMed:
Extraction of nutraceuticals from milk thistle: part II. Extraction with organic solvents.
PubMed:
Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1,4-dioxane ring system.
PubMed:
Analysis of the active components of silymarin.
PubMed:
Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum.
PubMed:
Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.
PubMed:
Stability of the constituents of Calendula, milk-thistle and passionflower tinctures by LC-DAD and LC-MS.
PubMed:
[Determination of the active flavonoids in silymarine].
PubMed:
Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin.
PubMed:
Inhibition of the superoxide anion release and hydrogen peroxide formation in PMNLs by flavonolignans.
PubMed:
Determination of active component in silymarin by RP-LC and LC/MS.
PubMed:
[Separation and determination of effective components in silymarin and preparations of silymarin by MECC].
PubMed:
Flavonolignan production from Silybum marianum transformed and untransformed root cultures.
PubMed:
Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase.
PubMed:
Activities of silymarin and its flavonolignans upon low density lipoprotein oxidizability in vitro.
PubMed:
Silybin and silydianin diminish the oxidative metabolism of human polymorphonuclear neutrophils.
PubMed:
Comparative pharmacokinetics of silipide and silymarin in rats.
PubMed:
Pharmacokinetics of silybin in bile following administration of silipide and silymarin in cholecystectomy patients.
PubMed:
[Effects of flavobion on nucleic acids in tissues of rats irradiated with gamma rays].
PubMed:
Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.
PubMed:
[Milk thistle (Silybum marianum, L., Gaertn.) in the feed of ketotic cows].
PubMed:
Advances in pharmacological studies of silymarin.
PubMed:
Silymarin: potent inhibitor of cyclic AMP phosphodiesterase.
PubMed:
[Structure of silandrin and silymonin, two new flavanolignans from a white blooming Silybum marianum variety].
PubMed:
[Bioavailability of silymarin, I: Volumes of distribution of silybin, silydianin, and silychristin from in-vitro data (author's transl)].
PubMed:
Silymarin, an inhibitor of prostaglandin synthetase.
PubMed:
Silymarin, an inhibitor of lipoxygenase.
PubMed:
[Changes in erythrocyte shape and volume caused by silymarin].
PubMed:
[Peroxidase isoenzymes in cress seedlings (Lepidium sativum L.) and their inhibition by silybin, silydianin and silychristin].
PubMed:
[Silymarin--an inhibitor of horseradish peroxidase (author's transl)].