nortrachelogenin

wikstromol

CAS: 34444-37-6 C20 H22 O7 MW: 374.38974000

Identification

Namenortrachelogenin
IUPAC3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
CAS Number34444-37-6
FDA UNIISearch
Molecular FormulaC20 H22 O7
Molecular Weight374.38974000
MDL NumberMFCD01725924

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 609.20 °C. @ 760.00 mm Hg (est)
Flash Point 423.00 °F. TCC ( 217.30 °C. ) (est)
logP (o/w) 0.920 (est)
Soluble in water, 2515 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for nortrachelogenin usage levels up tonot for fragrance use.
Recommendation for nortrachelogenin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

carissa edulis pine longleaf pine wikstroemia indica

Synonyms

dihydro-3-hydroxy-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-2(3H)-furanone 2(3H)- furanone, dihydro-3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]- 2(3H)- furanone,dihydro-3-hydroxy-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-,(3R-cis) 3- hydroxy-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydro-2(3H)-furanone 3- hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one 8'-(R)-4,4',8- trihydroxy-3,3'-dimethoxylignanolide wikstromol PubMed: Novel Lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model. PubMed: Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration. PubMed: New guaian-type sesquiterpene from Wikstroemia indica. PubMed: Chemical constituents and biological activities from roots of Enkleia siamensis. PubMed: The antitumor lignan Nortrachelogenin sensitizes prostate cancer cells to TRAIL-induced cell death by inhibition of the Akt pathway and growth factor signaling. PubMed: A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides. PubMed: Bioactive compounds from Carissa spinarum. PubMed: A new lignan glycoside from Juniperus rigida. PubMed: Wounding response in xylem of Scots pine seedlings shows wide genetic variation and connection with the constitutive defence of heartwood. PubMed: Simultaneous high-performance liquid chromatographic determination of Cedrus deodara active constituents and their pharmacokinetic profile in mice. PubMed: Chemically standardized isolates from Cedrus deodara stem wood having anticancer activity. PubMed: Lignans from Arnica species. PubMed: Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest. PubMed: Lignans from the roots of Wikstroemia indica and their DPPH radical scavenging and nitric oxide inhibitory activities. PubMed: Structural determinants of plant lignans for growth of mammary tumors and hormonal responses in vivo. PubMed: Lignans from Trachelospermum jasminoides. PubMed: [Isolation and structure identification of lignans from pine needles of pinus massoniana Lamb]. PubMed: Free radical scavenging active components from Cedrus deodara. PubMed: In vitro inhibitory effects of Daphne oleoides ssp. oleoides on inflammatory cytokines and activity-guided isolation of active constituents. PubMed: Enantioselective synthesis of (-)-wikstromol using a new approach via malic acid. PubMed: Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica. PubMed: Phenolic Constituents of Selaginella doederleinii. PubMed: Inhibition of potato cyst nematode hatch by lignans fromBupleurum salicifolium (Unbelliferae). PubMed: Stereoselectivity questions in the synthesis of wikstromol. PubMed: Plant Anticancer Agents XXXIII. Constituents of Passerina vulgaris1. PubMed: Plant anticancer agents XXXIII. Constituents of Passerina vulgaris. PubMed: Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica. PubMed: Wikstromol, antitumor lignan from Wikstroemia foetida var. oahuensis Gray and Wikstroemia uva-ursi Gray (Thymelaeaceae). PubMed: (+)-Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica. PubMed: (+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica.