nortrachelogenin
wikstromol
Identification
| Name | nortrachelogenin |
| IUPAC | 3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one |
| CAS Number | 34444-37-6 |
| FDA UNII | Search |
| Molecular Formula | C20 H22 O7 |
| Molecular Weight | 374.38974000 |
| MDL Number | MFCD01725924 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 609.20 °C. @ 760.00 mm Hg (est) |
| Flash Point | 423.00 °F. TCC ( 217.30 °C. ) (est) |
| logP (o/w) | 0.920 (est) |
| Soluble in | water, 2515 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for nortrachelogenin usage levels up to | not for fragrance use. |
| Recommendation for nortrachelogenin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
dihydro-3-hydroxy-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-2(3H)-furanone
2(3H)-
furanone, dihydro-3-hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-
2(3H)-
furanone,dihydro-3-hydroxy-3,4-bis((4-hydroxy-3-methoxyphenyl)methyl)-,(3R-cis)
3-
hydroxy-3,4-bis(4-hydroxy-3-methoxybenzyl)dihydro-2(3H)-furanone
3-
hydroxy-3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one
8'-(R)-4,4',8-
trihydroxy-3,3'-dimethoxylignanolide
wikstromol
PubMed:
Novel Lignan and stilbenoid mixture shows anticarcinogenic efficacy in preclinical PC-3M-luc2 prostate cancer model.
PubMed:
Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration.
PubMed:
New guaian-type sesquiterpene from Wikstroemia indica.
PubMed:
Chemical constituents and biological activities from roots of Enkleia siamensis.
PubMed:
The antitumor lignan Nortrachelogenin sensitizes prostate cancer cells to TRAIL-induced cell death by inhibition of the Akt pathway and growth factor signaling.
PubMed:
A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides.
PubMed:
Bioactive compounds from Carissa spinarum.
PubMed:
A new lignan glycoside from Juniperus rigida.
PubMed:
Wounding response in xylem of Scots pine seedlings shows wide genetic variation and connection with the constitutive defence of heartwood.
PubMed:
Simultaneous high-performance liquid chromatographic determination of Cedrus deodara active constituents and their pharmacokinetic profile in mice.
PubMed:
Chemically standardized isolates from Cedrus deodara stem wood having anticancer activity.
PubMed:
Lignans from Arnica species.
PubMed:
Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest.
PubMed:
Lignans from the roots of Wikstroemia indica and their DPPH radical scavenging and nitric oxide inhibitory activities.
PubMed:
Structural determinants of plant lignans for growth of mammary tumors and hormonal responses in vivo.
PubMed:
Lignans from Trachelospermum jasminoides.
PubMed:
[Isolation and structure identification of lignans from pine needles of pinus massoniana Lamb].
PubMed:
Free radical scavenging active components from Cedrus deodara.
PubMed:
In vitro inhibitory effects of Daphne oleoides ssp. oleoides on inflammatory cytokines and activity-guided isolation of active constituents.
PubMed:
Enantioselective synthesis of (-)-wikstromol using a new approach via malic acid.
PubMed:
Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica.
PubMed:
Phenolic Constituents of Selaginella doederleinii.
PubMed:
Inhibition of potato cyst nematode hatch by lignans fromBupleurum salicifolium (Unbelliferae).
PubMed:
Stereoselectivity questions in the synthesis of wikstromol.
PubMed:
Plant Anticancer Agents XXXIII. Constituents of Passerina vulgaris1.
PubMed:
Plant anticancer agents XXXIII. Constituents of Passerina vulgaris.
PubMed:
Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica.
PubMed:
Wikstromol, antitumor lignan from Wikstroemia foetida var. oahuensis Gray and Wikstroemia uva-ursi Gray (Thymelaeaceae).
PubMed:
(+)-Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica.
PubMed:
(+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica.