2'-fucosyl lactose

(2R,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-4,5- dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanal 2'- fucosyllactose 2'-O- fucosyllactose D- glucose, O-6-deoxy-alpha-L-galactopyranosyl-(1-2)-O-beta-D-galactopyranosyl-(1-4)- PubMed: Structural characterisation of human galectin-4 C-terminal domain -elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens. PubMed: Attenuation of food allergy symptoms following treatment with human milk oligosaccharides in a mouse model. PubMed: Recognition of human milk oligosaccharides by bacterial exotoxins. PubMed: Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants. PubMed: In vitro impact of human milk oligosaccharides on enterobacteriaceae growth. PubMed: Effects of a human milk oligosaccharide, 2'-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents. PubMed: Fecal microbiota composition of breast-fed infants is correlated with human milk oligosaccharides consumed. PubMed: Oligosaccharide composition of breast milk influences survival of uninfected children born to HIV-infected mothers in Lusaka, Zambia. PubMed: A 3-week pre-clinical study of 2′-fucosyllactose in farm piglets. PubMed: The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation. PubMed: Structure and substrate specificity of a eukaryotic fucosidase from Fusarium graminearum. PubMed: Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants. PubMed: Can an ancestral condition for milk oligosaccharides be determined? Evidence from the Tasmanian echidna (Tachyglossus aculeatus setosus). PubMed: Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation. PubMed: Human milk oligosaccharides influence maturation of human intestinal Caco-2Bbe and HT-29 cell lines. PubMed: Selective proliferation of intestinal Barnesiella under fucosyllactose supplementation in mice. PubMed: Ultra high performance liquid chromatography-tandem mass spectrometry method for the determination of soluble milk glycans in rat serum. PubMed: Pre-clinical safety evaluation of the synthetic human milk, nature-identical, oligosaccharide 2'-O-Fucosyllactose (2'FL). PubMed: WbgL: a novel bacterial α1,2-fucosyltransferase for the synthesis of 2'-fucosyllactose. PubMed: 2'-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk. PubMed: Select human milk oligosaccharides directly modulate peripheral blood mononuclear cells isolated from 10-d-old pigs. PubMed: Bioengineered 2'-fucosyllactose and 3-fucosyllactose inhibit the adhesion of Pseudomonas aeruginosa and enteric pathogens to human intestinal and respiratory cell lines. PubMed: The human milk metabolome reveals diverse oligosaccharide profiles. PubMed: Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes. PubMed: "Amide resonance" in the catalysis of 1,2-α-L-fucosidase from Bifidobacterium bifidum. PubMed: Construction of Escherichia coli strains with chromosomally integrated expression cassettes for the synthesis of 2'-fucosyllactose. PubMed: Neutral and acidic milk oligosaccharides of the striped skunk (Mephitidae: Mephitis mephitis). PubMed: Human milk oligosaccharides inhibit rotavirus infectivity in vitro and in acutely infected piglets. PubMed: In vitro fermentation characteristics of select nondigestible oligosaccharides by infant fecal inocula. PubMed: Comprehensive profiles of human milk oligosaccharides yield highly sensitive and specific markers for determining secretor status in lactating mothers. PubMed: The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota. PubMed: Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm. PubMed: Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity. PubMed: Whole cell biosynthesis of a functional oligosaccharide, 2'-fucosyllactose, using engineered Escherichia coli. PubMed: Development of biosensor-based assays to identify anti-infective oligosaccharides. PubMed: Chemical characterization of milk oligosaccharides of an African lion (Panthera leo) and a clouded leopard (Neofelis nebulosa). PubMed: Utilization of natural fucosylated oligosaccharides by three novel alpha-L-fucosidases from a probiotic Lactobacillus casei strain. PubMed: Determination of sialyl and neutral oligosaccharide levels in transition and mature milks of Samoan women, using anthranilic derivatization followed by reverse phase high performance liquid chromatography. PubMed: Fucosylated glycan inhibition of human hepatocellular carcinoma cell migration through binding to chemokine receptors. PubMed: Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates. PubMed: Multivalent human blood group ABH and Lewis glycotopes are key recognition factors for a LFuc>Man binding lectin from phytopathogenic Ralstonia solanacearum. PubMed: Improved determination of milk oligosaccharides using a single derivatization with anthranilic acid and separation by reversed-phase high-performance liquid chromatography. PubMed: 1,2-alpha-l-Fucosynthase: a glycosynthase derived from an inverting alpha-glycosidase with an unusual reaction mechanism. PubMed: Structural basis of the catalytic reaction mechanism of novel 1,2-alpha-L-fucosidase from Bifidobacterium bifidum. PubMed: Variation of major neutral oligosaccharides levels in human colostrum. PubMed: Oligosaccharides in colostrum of Italian and Burkinabe women. PubMed: Interactions of the fucose-specific Pseudomonas aeruginosa lectin, PA-IIL, with mammalian glycoconjugates bearing polyvalent Lewis(a) and ABH blood group glycotopes. PubMed: Purification and characterization of extracellular 1,2-alpha-L-fucosidase from Bacillus cereus. PubMed: The fucose-binding lectin from Ralstonia solanacearum. A new type of beta-propeller architecture formed by oligomerization and interacting with fucoside, fucosyllactose, and plant xyloglucan. PubMed: An unusual anti-H lectin inhibited by milk from individuals with the Bombay phenotype. PubMed: Molecular cloning and characterization of Bifidobacterium bifidum 1,2-alpha-L-fucosidase (AfcA), a novel inverting glycosidase (glycoside hydrolase family 95). PubMed: Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose. PubMed: Characterization of oligosaccharides in milk of bearded seal (Erignathus barbatus). PubMed: Differences in oligosaccharide pattern of a sample of polar bear colostrum and mid-lactation milk. PubMed: Chemical characterization of the oligosaccharides in milk of high Arctic harbour seal (Phoca vitulina vitulina). PubMed: [Studies of oligosaccharide specificity of perch roe fucolectin, using gold labeled neoglycoproteins]. PubMed: Determination of each neutral oligosaccharide in the milk of Japanese women during the course of lactation. PubMed: Cloning of a rat gene encoding the histo-blood group A enzyme. Tissue expression of the gene and of the A and B antigens. PubMed: High-resolution crystal structures of Erythrina cristagalli lectin in complex with lactose and 2'-alpha-L-fucosyllactose and correlation with thermodynamic binding data. PubMed: Chemical characterization of the oligosaccharides in beluga (Delphinapterus leucas) and Minke whale (Balaenoptera acutorostrata) milk. PubMed: Comparison of oligosaccharides in milk specimens from humans and twelve other species. PubMed: Synthesis of the milk oligosaccharide 2'-fucosyllactose using recombinant bacterial enzymes. PubMed: Structural characterization of fucose-containing oligosaccharides by high-performance liquid chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. PubMed: Chemical characterisation of the oligosaccharides in hooded seal (Cystophora cristata) and Australian fur seal (Arctocephalus pusillus doriferus) milk. PubMed: Chemical characterization of milk oligosaccharides of the polar bear, Ursus maritimus. PubMed: Structural basis of carbohydrate recognition by lectin II from Ulex europaeus, a protein with a promiscuous carbohydrate-binding site. PubMed: A lectin from an edible mushroom Pleurotus ostreatus as a food intake-suppressing substance. PubMed: Variability of human milk neutral oligosaccharides in a diverse population. PubMed: Isolation and characterization from porcine serum of a soluble sulfotransferase responsible for 6-O-sulfation of the galactose residue in 2'-fucosyllactose: implications in the synthesis of the ligand for L-selectin. PubMed: Chemical characterization of milk oligosaccharides of the Japanese black bear, Ursus thibetanus japonicus. PubMed: Occurrence of an unusual lactose sulfate in dog milk. PubMed: Purification and characterization of a lymph node sulfotransferase responsible for 6-O-sulfation of the galactose residues in 2'-fucosyllactose and other sialyl LewisX-related sugars. PubMed: Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines. PubMed: Identification of fucose alpha(1-2) galactose epitope-containing glycoproteins from rat hippocampus. PubMed: Milk oligosaccharide profiles by reversed-phase HPLC of their perbenzoylated derivatives. PubMed: Multiple fucosyltransferases and their carbohydrate ligands are involved in spermatogenic cell-Sertoli cell adhesion in vitro in rats. PubMed: Identification of 2'-fucosyllactose in milk of the crabeater seal (Lobodon carcinophagus). PubMed: Immobilized Lotus tetragonolobus agglutinin binds oligosaccharides containing the Le(x) determinant. PubMed: Localized agglutinin staining in muscle capillaries from normal and very old atrophic human muscle using winged bean (Psophocarpus tetragonolobus) lectin. PubMed: Thermodynamics of monosaccharide and disaccharide binding to Erythrina corallodendron lectin. PubMed: Remodeling of mouse milk glycoconjugates by transgenic expression of a human glycosyltransferase. PubMed: Glycosidic specificity of fucosyltransferases present in rat epididymal spermatozoa. PubMed: Characterization of Biomphalaria alexandrina-derived lectins recognizing a fucosyllactose-related determinant on schistosomes. PubMed: Presence of multiple fucosyltransferases in rat Sertoli cells and spermatogenic cells. PubMed: Purification and characterization of alpha-L-fucosidase from Chinese hamster ovary cell culture supernatant. PubMed: Fucose and fucose-containing sugar epitopes enhance hippocampal long-term potentiation in the freely moving rat. PubMed: Lactose as affinity eluent and a synthetic sulfated copolymer as inhibitor, in conjunction with synthetic and natural acceptors, differentiate human milk Lewis-type and plasma-type alpha-L-fucosyltransferases. PubMed: Purification and properties of the alpha-3/4-L-fucosyltransferase released into the culture medium during the growth of the human A431 epidermoid carcinoma cell line. PubMed: Purification of the Lewis blood-group gene associated alpha-3/4-fucosyltransferase from human milk: an enzyme transferring fucose primarily to type 1 and lactose-based oligosaccharide chains. PubMed: Assay of alpha 1,3 N-acetyl-D-galactosaminyl transferase by affinity chromatography. PubMed: Variations in human liver fucosyltransferase activities in hepatobiliary diseases. PubMed: Thermodynamic analysis of ligand binding to winged bean (Psophocarpus tetragonolobus) acidic agglutinin reveals its specificity for terminally monofucosylated H-reactive sugars. PubMed: Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene. PubMed: Liquid ion-exchange chromatography under pressure of milk oligosaccharides using a pulsed amperometric detector. PubMed: Separation of human milk oligosaccharides by recycling chromatography. First isolation of lacto-N-neo-difucohexaose II and 3'-Galactosyllactose from this source. PubMed: Blood group ABO and Lewis antigens in bladder tumors: correlation between glycosyltransferase activity and antigen expression. PubMed: Substrate specificity of fucosyltransferase purified from human parotid saliva. PubMed: Studies on anti-H reagents. PubMed: Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase. PubMed: Determination of the structures of fucosyl-lactose and difucosyl-lactose from the milk of monotremes, using 13C-n.m.r. spectroscopy. PubMed: Regulatory mutations in CHO cells induce expression of the mouse embryonic antigen SSEA-1. PubMed: A monoclonal antibody that precipitates the glycoprotein receptor for epidermal growth factor is directed against the human blood group H type 1 antigen. PubMed: An enzyme basis for blood type A intermediate status. PubMed: Purification of an almond emulsin fucosidase on Cibacron blue-sepharose and demonstration of its activity toward fucose-containing glycoproteins. PubMed: A case of weak blood group B expression (Bm) associated with abnormal blood group galactosyltransferase. PubMed: Abnormal blood group galactosyltransferase in blood type A1B-subjects whose sera contain anti-B agglutinin. PubMed: Improved method for the isolation of 2' fucosyllactose from human milk. PubMed: Human salivary fucosyltransferases : evidence for two distinct alpha-3-L-fucosyltransferase activities one or which is associated with the Lewis blood group Le gene. PubMed: Membrane abnormality in red blood cells with weak type B expression. PubMed: Probable biosynthetic pathway for the synthesis of the B antigen for Bh variants. PubMed: A comparison of the alpha-L-fucosidase activities of human liver and serum. PubMed: Porcine A blood group-specific N-acetylgalactosaminyltransferase. PubMed: [Serum glycosyltransferase activity associated with antigen biosynthesis in blood groups A and B. Study of normal B group and cis AB group subjects]. PubMed: Qualitative differences in the N-acetyl-D-galactosaminyltransferases produced by human A1 and A2 genes. PubMed: N-acetyl-D-galactosaminyltransferase in human serum and erythrocyte membranes. PubMed: Correlation between secretor status and the occurrence of 2'-fucosyllactose in human milk.