Identification

Namezaluzanin C
IUPAC(3aS,6aR,8S,9aR,9bS)-8-hydroxy-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
CAS Number16838-87-2
FDA UNIISearch
Molecular FormulaC15 H18 O3
Molecular Weight246.30606000
Nikkaji NumberJ14.016C

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 2460 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for zaluzanin C usage levels up tonot for fragrance use.
Recommendation for zaluzanin C flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

zaluzania robinsonii

Synonyms

3beta,6alpha- dihydroxy-1beta-guaia-4(15),10(14),11(13)-trien-12-oic acid gamma-lactone (3aS,6aR,8S,9aR,9bS)-8- hydroxy-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one PubMed: Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation. PubMed: [Chemical constituents of Myripnois dioica]. PubMed: Guaianolide sesquiterpenoids from Ainsliaea yunnanensis. PubMed: Inhibition of COX-2 and NF-κB1 Gene Expression, NO Production, 5-LOX, and COX-1 and COX-2 Enzymes by Extracts and Constituents of Onopordum acanthium. PubMed: A new sesquiterpene lactone and other constituents of Moquiniastrum polymorphum subsp. floccosum (Asteraceae). PubMed: Bioactivity-guided isolation of antiproliferative compounds from the roots of Onopordum acanthium. PubMed: Sesquiterpene lactones from Lactuca canadensis and their chemotaxonomic significance. PubMed: [Lactone constituents of Saussurea involucrata]. PubMed: A dimeric sesquiterpene, gochnatiolide A. PubMed: Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia. PubMed: Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 macrophages by sesquiterpene lactones. PubMed: Selective deacetylation of zaluzanin D using transformed Escherichia coli cultures. PubMed: Microbial transformation of zaluzanin-D. PubMed: Sesquiterpene lactones and phenylpropanoids from Cosmos pringlei. PubMed: Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction. PubMed: Fungicidal activity of natural and synthetic sesquiterpene lactone analogs. PubMed: Inhibition of oxygen evolution by zaluzanin C. PubMed: The mode of action of zaluzanin C, an inhibitor of translation in eukaryotes. PubMed: Medicinal plants from Mexico. Part XXII. Isolation of zaluzanin-C a citotoxic sesquiterpenlactone from Zaluzania parthenoides.