zaluzanin C
Identification
| Name | zaluzanin C |
| IUPAC | (3aS,6aR,8S,9aR,9bS)-8-hydroxy-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one |
| CAS Number | 16838-87-2 |
| FDA UNII | Search |
| Molecular Formula | C15 H18 O3 |
| Molecular Weight | 246.30606000 |
| Nikkaji Number | J14.016C |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 2460 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for zaluzanin C usage levels up to | not for fragrance use. |
| Recommendation for zaluzanin C flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
3beta,6alpha-
dihydroxy-1beta-guaia-4(15),10(14),11(13)-trien-12-oic acid gamma-lactone
(3aS,6aR,8S,9aR,9bS)-8-
hydroxy-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one
PubMed:
Zaluzanin C (ZC) induces osteoblast differentiation through regulating of osteogenic genes expressions in early stage of differentiation.
PubMed:
[Chemical constituents of Myripnois dioica].
PubMed:
Guaianolide sesquiterpenoids from Ainsliaea yunnanensis.
PubMed:
Inhibition of COX-2 and NF-κB1 Gene Expression, NO Production, 5-LOX, and COX-1 and COX-2 Enzymes by Extracts and Constituents of Onopordum acanthium.
PubMed:
A new sesquiterpene lactone and other constituents of Moquiniastrum polymorphum subsp. floccosum (Asteraceae).
PubMed:
Bioactivity-guided isolation of antiproliferative compounds from the roots of Onopordum acanthium.
PubMed:
Sesquiterpene lactones from Lactuca canadensis and their chemotaxonomic significance.
PubMed:
[Lactone constituents of Saussurea involucrata].
PubMed:
A dimeric sesquiterpene, gochnatiolide A.
PubMed:
Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia.
PubMed:
Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression in RAW 264.7 macrophages by sesquiterpene lactones.
PubMed:
Selective deacetylation of zaluzanin D using transformed Escherichia coli cultures.
PubMed:
Microbial transformation of zaluzanin-D.
PubMed:
Sesquiterpene lactones and phenylpropanoids from Cosmos pringlei.
PubMed:
Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction.
PubMed:
Fungicidal activity of natural and synthetic sesquiterpene lactone analogs.
PubMed:
Inhibition of oxygen evolution by zaluzanin C.
PubMed:
The mode of action of zaluzanin C, an inhibitor of translation in eukaryotes.
PubMed:
Medicinal plants from Mexico. Part XXII. Isolation of zaluzanin-C a citotoxic sesquiterpenlactone from Zaluzania parthenoides.