ethyl nitrite

nitrous acid, ethyl ester

CAS: 109-95-5 C2 H5 N O2 MW: 75.06725000 ethereal

Identification

Nameethyl nitrite
IUPACethyl nitrite
CAS Number109-95-5
EINECS203-722-6
FDA UNII8C7CJ279RV
Molecular FormulaC2 H5 N O2
Molecular Weight75.06725000
MDL NumberMFCD00010257
Nikkaji NumberJ47.917I
Beilstein1699562
CoE Number11869

Regulatory

FEMA Number2446
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)109-95-5 ; ETHYL NITRITE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.90090 @ 25.00 °C.
Boiling Point 17.40 to 18.00 °C. @ 760.00 mm Hg
Vapor Pressure 905.966980 mmHg @ 25.00 °C. (est)
Flash Point 59.00 °F. TCC ( 15.00 °C. )
logP (o/w) 0.712 (est)
Soluble in alcohol
Insoluble in water

Organoleptic Properties

Odor Description at 1.00 % in propylene glycol.

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation Toxicityinhalation-rat LC50 160 ppm/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: EXCITEMENT\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nLUNGS, THORAX, OR RESPIRATION: CYANOSIS']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for ethyl nitrite usage levels up tonot for fragrance use.
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy0.10000
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

ethyl nitrite 15% in ethanol ethyl nitrite solution ethylnitrite hyponitrous ether nitrosyl ethoxide nitrous acid ethyl ester nitrous acid, ethyl ester nitrous ether nitrous ether 15% in ethanol nitrous ethyl ether spirit of nitrous ether sweet spirit of nitre PubMed: Chirped-Pulse millimeter-Wave spectroscopy for dynamics and kinetics studies of pyrolysis reactions. PubMed: S-nitrosylation therapy to improve oxygen delivery of banked blood. PubMed: Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death. PubMed: A comparison of organic and inorganic nitrates/nitrites. PubMed: Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage. PubMed: Inclusion of a nitric oxide congener in the insufflation gas repletes S-nitrosohemoglobin and stabilizes physiologic status during prolonged carbon dioxide pneumoperitoneum. PubMed: Transport rather than diffusion-dependent route for nitric oxide gas activity in alveolar epithelium. PubMed: Formation of nitric oxide, ethyl nitrite and an oxathiolone derivative of caffeic acid in a mixture of saliva and white wine. PubMed: Protection from lipopolysaccharide-induced lung injury by augmentation of airway S-nitrosothiols. PubMed: [Effect of ethyl nitrite versus inhaled nitric oxide in a rat model of acute pulmonary hypertension]. PubMed: The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions. PubMed: Transformation of ethyl alcohol to ethyl nitrite in acidified saliva: possibility of its occurrence in the stomach. PubMed: Isomeric recognition by ion/molecule reactions: the ionized phenol-cyclohexadienone case. PubMed: Ab initio, density functional theory, and continuum solvation model prediction of the product ratio in the S(N)2 reaction of NO2(-) with CH3CH2Cl and CH3CH2Br in DMSO solution. PubMed: Efficacy of ethyl nitrite in reversing surgical vasospasm. PubMed: Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats. PubMed: Inclusion of an S-nitrosylating agent in the insufflating gas does not alter gastric activity in rats following pneumoperitoneum. PubMed: A nitric oxide processing defect of red blood cells created by hypoxia: deficiency of S-nitrosohemoglobin in pulmonary hypertension. PubMed: Formation of ethyl nitrite in vivo after ethanol administration. PubMed: A method to attenuate pneumoperitoneum-induced reductions in splanchnic blood flow. PubMed: Fourier transform infrared-probed O(3P) microreactor: demonstration with ethylene reactions in argon matrix. PubMed: The combined solid/solution-phase synthesis of nitrosamines: the evolution of the "libraries from libraries" concept. PubMed: Inhaled ethyl nitrite gas for persistent pulmonary hypertension in infants. PubMed: Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn. PubMed: Spin-labeled 1-alkyl-1-nitrosourea synergists of antitumor antibiotics. PubMed: Preparation and properties of S-nitroso-L-cysteine ethyl ester, an intracellular nitrosating agent. PubMed: Synthesis, characterization, solid-state molecular structures, and deprotonation reactions of cationic alcohol complexes of osmium nitrosyl porphyrins. PubMed: [A gas chromatographic method for detecting nitrites in the blood and stomach contents]. PubMed: Direct demonstration of NO formation in vivo from organic nitrites and nitrates, and correlation to effects on blood pressure and to in vitro effects. PubMed: Oxidation of deoxyhemerythrin to semi-methemerythrin by nitrite. PubMed: Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, Basc and micronucleus tests. PubMed: Oxidation of hemoglobin and myoglobin by alkyl nitrites inhibition by oxygen. PubMed: Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites. PubMed: Ethyl nitrite. The in vivo synthesis of a mutagenic substance from tobacco smoke and ethanol. PubMed: Sudden death in an infant from methemoglobinemia after administration of "sweet spirits of nitre". PubMed: [Acute poisoning due to inhalation of ethyl nitrite vapors].