kadsurenone

5- allyl-2-(3,4-dimethoxy-phenyl)-3a-methoxy-3-methyl-3,3a-dihydro-2H-benzofuran-6-one (2S,3R,3aS)-5- allyl-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-3,3a-dihydro-1-benzofuran-6(2H)-one 6(2H)- benzofuranone, 2-(3,4-dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propen-1-yl)-, (2S,3R,3aS)- denudatin B (2S-(2alpha,3beta,3aalpha))-2-(3,4- dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propenyl)-6(2H)-benzofuranone (2S,3R,3aS)-2-(3,4- dimethoxyphenyl)-3a-methoxy-3-methyl-5-prop-2-enyl-2,3-dihydro-1-benzofuran-6-one PubMed: Development of an LC-MS/MS method for quantification of kadsurenone in rat plasma and its application to a pharmacokinetic study. PubMed: Platelet-activating factor (PAF)-antagonists of natural origin. PubMed: [Neolignans and lignan from Piper wallichii]. PubMed: Pharmacokinetics of kadsurenone and its interaction with cyclosporin A in rats using a combined HPLC and microdialysis system. PubMed: [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. PubMed: Ambident effect of a p-sulfinyl group for the introduction of two carbon substituents to phenol rings: a convergent synthesis of diverse benzofuran neolignans. PubMed: Platelet-activating factor antagonists. PubMed: The biological activity of acetylated sphingosylphosphorylcholine derivatives. PubMed: [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. PubMed: [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. PubMed: Trimucytin: a collagen-like aggregating inducer isolated from Trimeresurus mucrosquamatus snake venom. PubMed: Stimulation of human polymorphonuclear leukocytes by leukotriene B4 and platelet-activating factor: an ultrastructural and pharmacological study. PubMed: [PAF antagonistic benzofuran neolignans from Piper kadsura]. PubMed: PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. PubMed: Stimulation of tumour necrosis factor release by cytotoxic analogues of platelet-activating factor. PubMed: Antagonism of platelet-activating factor-induced increase in cytosolic free calcium concentration in human endothelial cells. PubMed: Platelet-activating factor (PAF) receptor antagonists inhibit arachidonic acid induced platelet aggregation in rabbit whole blood. PubMed: Comparison of the actions of some platelet-activating factor antagonists on platelets and aortic smooth muscles. PubMed: Inhibition of immune complex-induced enteropathy by three different platelet-activating factor receptor antagonists. PubMed: The rational search for natural neolignans. PubMed: Pharmacologic characterization of the rabbit neutrophil receptor for platelet-activating factor. PubMed: Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. PubMed: Lipophilicity force field profile: an expressive visualization of the lipophilicity molecular potential gradient. PubMed: Distinct stimulatory effect of platelet-activating factor on prostaglandin I2 and thromboxane A2 biosynthesis by rat dental pulp. PubMed: Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. PubMed: Development of specific functionally active receptors for platelet-activating factor in HL-60 cells following granulocytic differentiation. PubMed: Kadsurenone and other related lignans as antagonists of platelet-activating factor receptor. PubMed: Further characterization of PAF receptor and novel antagonists. PubMed: Acute microcirculatory effects of platelet-activating factor. PubMed: Antagonism of platelet activating factor-induced chemiluminescence in guinea-pig peritoneal macrophages in differing states of activation. PubMed: PAF-receptor. 1. 'Cache-oreilles' effect of selected high-potency platelet-activating factor (PAF) antagonists. PubMed: Pharmacologic modulation of D-49 phospholipase A2-induced paw edema in the mouse. PubMed: Preliminary studies on phospholipase A2-induced mouse paw edema as a model to evaluate antiinflammatory agents. PubMed: Antagonism of Paf-induced oedema formation in rabbit skin: a comparison of different antagonists. PubMed: Platelet activating factor is a potent colonic secretagogue with actions independent of specific PAF receptors. PubMed: Platelet-activating factor-induced calcium mobilization in human platelets and neutrophils: effects of PAF-acether antagonists. PubMed: [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. PubMed: Platelet-activating factor stimulates arachidonic acid metabolism in rat liver cells (C-9 cell line) by a receptor-mediated mechanism. PubMed: Metabolism of kadsurenone and 9,10-dihydrokadsurenone in rhesus monkeys and rat liver microsomes. PubMed: Enhanced human monocyte cytotoxicity by platelet-activating factor. PubMed: Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction. PubMed: Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. PubMed: Effect of platelet activating factor on leukocyte-endothelial cell interactions. PubMed: Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin. PubMed: Identification of platelet-activating factor receptors in P388D1 murine macrophages. PubMed: Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. PubMed: Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage. PubMed: Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. PubMed: Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. PubMed: Effect of platelet activating factor antagonists on cultured rat mesangial cells. PubMed: Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. PubMed: Specific receptor sites for platelet activating factor on rat liver plasma membranes. PubMed: Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay. PubMed: Pharmacologic modulation of PAF-induced mortality in mice. PubMed: Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor. PubMed: Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. PubMed: Structure-activity relationships of kadsurenone analogues. PubMed: Species difference in the specific receptors of platelet activating factor. PubMed: Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. PubMed: The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation. PubMed: Characterization of platelet activating factor (PAF)-acether-induced contractions of guinea-pig lung strips by selected inhibitors of arachidonic acid metabolism and by PAF-acether antagonists. PubMed: Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. PubMed: Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. PubMed: Comparative effects of drugs on leukotrienes-, PAF-acether- and histamine- induced contractions of guinea-pig lung parenchymal strips. PubMed: [Neolignans from Piper hancei Maxim]. PubMed: Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. PubMed: Kadsurenone distinguishes between different platelet activating factor receptor subtypes on macrophages and polymorphonuclear leucocytes. PubMed: Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. PubMed: Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. PubMed: Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds. PubMed: Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. PubMed: Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. PubMed: trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. PubMed: [Antagonists of platelet activating factor]. PubMed: Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. PubMed: Specific binding sites for platelet activating factor in human lung tissues. PubMed: Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. PubMed: Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. PubMed: The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor.