5-methoxyflavone
4H-1-benzopyran-4-one, 5-methoxy-2-phenyl-
Identification
| Name | 5-methoxyflavone |
| IUPAC | 5-methoxy-2-phenylchromen-4-one |
| CAS Number | 42079-78-7 |
| EINECS | 255-652-0 |
| FDA UNII | Search |
| Molecular Formula | C16 H12 O3 |
| Molecular Weight | 252.26924000 |
| MDL Number | MFCD00016942 |
| Nikkaji Number | J278.326F |
| XlogP3 | 3.50 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 422.50 °C. @ 760.00 mm Hg (est) |
| Flash Point | 394.00 °F. TCC ( 201.10 °C. ) (est) |
| logP (o/w) | 3.470 (est) |
| Soluble in | water, 19.78 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for 5-methoxyflavone usage levels up to | not for fragrance use. |
| Recommendation for 5-methoxyflavone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 5-methoxy-2-phenyl-
5-
methoxy-2-phenyl-4-benzopyrone
5-
methoxy-2-phenyl-4H-chromen-4-one
5-
methoxy-2-phenylchromen-4-one
PubMed:
A validated LC-MS/MS determination method for the illegal food additive rhodamine B: Applications of a pharmacokinetic study in rats.
PubMed:
Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.
PubMed:
Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity.
PubMed:
High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite.
PubMed:
Metabolism of Kaempferia parviflora polymethoxyflavones by human intestinal bacterium Bautia sp. MRG-PMF1.
PubMed:
[Further chemical investigation of leaves of Aquilaria Sinensis].
PubMed:
Phenolic constituents of Knautia arvensis aerial parts.
PubMed:
Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines.
PubMed:
[Chemical constituents of rhizoma imperatae and their anti-complementary activity].
PubMed:
A new antioxidant flavonoid from the lianas of Gnetum macrostachyum.
PubMed:
Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone.
PubMed:
Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone.
PubMed:
Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones.
PubMed:
Studies on the constituents of roots of Scutellaria planipes.
PubMed:
Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.
PubMed:
Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.
PubMed:
Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.
PubMed:
Flavonoid-induced gastroprotection in rats: role of blood flow and leukocyte adherence.
PubMed:
Synthesis and biological evaluation of substituted flavones as gastroprotective agents.
PubMed:
Phenolics induced in Beta vulgaris by Rhizoctonia solani infection.