formononetin

isoflavone, 7-hydroxy-4'-methoxy-

CAS: 485-72-3 C16 H12 O4 MW: 268.26844000

Identification

Nameformononetin
IUPAC7-hydroxy-3-(4-methoxyphenyl)chromen-4-one
CAS Number485-72-3
EINECS207-623-9
FDA UNII295DQC67BJ
Molecular FormulaC16 H12 O4
Molecular Weight268.26844000
MDL NumberMFCD00016948
Nikkaji NumberJ12.525C
Beilstein237979

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 256.50 °C. @ 760.00 mm Hg
Boiling Point 479.40 °C. @ 760.00 mm Hg (est)
Flash Point 362.00 °F. TCC ( 183.40 °C. ) (est)
logP (o/w) 2.960 (est)
Soluble in water, 157.3 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants, skin conditioning, skin protecting
Recommendation for formononetin usage levels up tonot for fragrance use.
Recommendation for formononetin flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

baboonwood bean mung bean bean mung bean plant chickpea seed clover red clover fenugreek fenugreek plant pea soybean seed soybean shoot

Synonyms

4H-1- benzopyran-4-one, 7-hydroxy-3- (4-methoxyphenyl)- 4H-1- benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- 4H-1- benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- (9CI) biochanin B iso flavone, 7-hydroxy-4'-methoxy- iso flavone, 7-hydroxy-4'-methoxy- (8CI) formonetin formonoetin formononectin formononetine formononetol 7- hydroxy-3-(4-methoxy-phenyl)-chromen-4-one 7- hydroxy-3-(4-methoxyphenyl)-4-benzopyrone 7- hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one 7- hydroxy-3-(4-methoxyphenyl)-4H-benzopyran-4-one 7- hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-on 7- hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one 7- hydroxy-3-(4-methoxyphenyl)chromen-4-one 7- hydroxy-3-(4-methoxyphenyl)chromone 7- hydroxy-3-(4'-methoxyphenyl)-4H-benzopyran-4-one 7- hydroxy-4'-methoxy-Isoflavone (8CI) 7- hydroxy-4'-methoxyisoflavanone 7- hydroxy-4'-methoxyisoflavone 7- hydroxy-4'-methoxyisoflavone*4'-O-methyldaidzein neochanin PubMed: Investigation of antioxidant interactions between Radix Astragali and Cimicifuga foetida and identification of synergistic antioxidant compounds. PubMed: Comparative studies on the constituents, antioxidant and anticancer activities of extracts from different varieties of corn silk. PubMed: The isoflavone irilone contributes to the estrogenic potential of dietary supplements containing red clover. PubMed: Development of a food compositional database for the estimation of dietary intake of phyto-oestrogens in a group of postmenopausal women previously treated for breast cancer and validation with urinary excretion. PubMed: A modified QuEChERS method as sample treatment before the determination of isoflavones in foods by ultra-performance liquid chromatography-triple quadrupole mass spectrometry. PubMed: Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes. PubMed: Germination dramatically increases isoflavonoid content and diversity in chickpea (Cicer arietinum L.) seeds. PubMed: The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang. PubMed: Effects of sodium metavanadate and germination on the sprouting of chickpeas and its content of vanadium, formononetin and biochanin A in the sprouts. PubMed: Effects of sodium selenite and germination on the sprouting of chickpeas (Cicer arietinum L.) and its content of selenium, formononetin and biochanin A in the sprouts. PubMed: Condensed tannins and flavonoids from the forage legume sulla (Hedysarum coronarium). PubMed: Association between dietary phyto-oestrogens and bone density in men and postmenopausal women. PubMed: Occurrence and mass balance of isoflavones on an experimental grassland field. PubMed: Phytoestrogen intake and cardiovascular risk markers in Bangladeshi postmenopausal women. PubMed: ZnO-ZnS QDs interfacial heterostructure for drug and food delivery application: enhancement of the binding affinities of flavonoid aglycones to bovine serum albumin. PubMed: Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α. PubMed: PAMPA permeability, plasma protein binding, blood partition, pharmacokinetics and metabolism of formononetin, a methoxylated isoflavone. PubMed: HPLC/DAD/MS and antioxidant activity of isoflavone-based food supplements. PubMed: Quantification of five isoflavones and coumestrol in various solid agroenvironmental matrices using ¹³c₃-labeled internal standards. PubMed: Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. PubMed: Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. PubMed: Study on the relevance between beany flavor and main bioactive components in Radix Astragali. PubMed: Red clover (Trifolium pratense L.) isoflavones: root phenolic compounds affected by biotic and abiotic stress factors. PubMed: Isoflavones in coffee: influence of species, roast degree, and brewing method. PubMed: Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. PubMed: Anticancer effects of flavonoid derivatives isolated from Millettia reticulata Benth in SK-Hep-1 human hepatocellular carcinoma cells. PubMed: Enhancement of the encapsulation and transmembrane permeation of isoflavone-containing red clover extracts in phospholipid-based microemulsions using different extraction processes. PubMed: Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.). PubMed: Equol in milk of dairy cows is derived from forage legumes such as red clover. PubMed: Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells. PubMed: [Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin]. PubMed: Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats. PubMed: Phytoestrogen content of cereals and cereal-based foods consumed in the UK. PubMed: Effect of forage on the content of phyto-oestrogens in bovine milk. PubMed: Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. PubMed: Phytoestrogen content of foods of animal origin: dairy products, eggs, meat, fish, and seafood. PubMed: Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons. PubMed: Isoflavonoid composition of a callus culture of the relict tree Maackia amurensis Rupr. et Maxim. PubMed: Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial. PubMed: Determination of phytoestrogens in dietary supplements by LC-MS/MS. PubMed: Phenolic compounds contribute to dark bran pigmentation in hard white wheat. PubMed: Dietary phytoestrogens, including isoflavones, lignans, and coumestrol, in nonvitamin, nonmineral supplements commonly consumed by women in Canada. PubMed: Quantification of six phytoestrogens at the nanogram per liter level in aqueous environmental samples using 13C3-labeled internal standards. PubMed: Analysis of flavonoid phytoestrogens in botanical and ephedra-containing dietary supplements. PubMed: High levels of equol in organic skimmed Finnish cow milk. PubMed: [Study on the chemical constituents of flavones from corn silk]. PubMed: Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). PubMed: Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. PubMed: Estimated intakes of isoflavones and coumestrol in Korean population. PubMed: Quantification and stability studies on the flavonoids of Radix hedysari. PubMed: Analysis of isoflavones in foods and dietary supplements. PubMed: Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. PubMed: Isoflavone profiles of red clovers and their distribution in different parts harvested at different growing stages. PubMed: The isoflavone content of commercially-available feline diets in New Zealand. PubMed: Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study. PubMed: Isoflavonoids are present in Arabidopsis thaliana despite the absence of any homologue to known isoflavonoid synthases. PubMed: Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry. PubMed: Antioxidant activity of isoflavones and their major metabolites using different in vitro assays. PubMed: Thermal degradation kinetics of isoflavone aglycones from soy and red clover. PubMed: Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. PubMed: High performance liquid chromatographic analysis of isoflavones in medicinal herbs. PubMed: Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones and estrogenic activity. PubMed: Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. PubMed: Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages. PubMed: Red clover Trifolium pratense L. phytoestrogens: UV-B radiation increases isoflavone yield, and postharvest drying methods change the glucoside conjugate profiles. PubMed: Supercritical fluid extraction of isoflavones from biological samples with ultra-fast high-performance liquid chromatography/mass spectrometry. PubMed: Effects of the environment, cultivar, maturity, and preservation method on red clover isoflavone concentration. PubMed: Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). PubMed: Isoflavones modulate the glucuronidation of estradiol in human liver microsomes. PubMed: Evaluation of isoflavone aglycon and glycoside distribution in soy plants and soybeans by fast column high-performance liquid chromatography coupled with a diode-array detector. PubMed: In vitro free radical and ONOO- scavengers from Sophora flavescens. PubMed: Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy? PubMed: Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects. PubMed: Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover). PubMed: Assessment of the reactivity of selected isoflavones against proteins in comparison to quercetin. PubMed: LC/UV/ESI-MS analysis of isoflavones in Edamame and Tofu soybeans. PubMed: Identification of phytoestrogens in bovine milk using liquid chromatography/electrospray tandem mass spectrometry. PubMed: Phyto-oestrogen levels in foods: the design and construction of the VENUS database. PubMed: Oxidative metabolism and genotoxic potential of major isoflavone phytoestrogens. PubMed: Metabolism of biochanin A and formononetin by human liver microsomes in vitro. PubMed: Intake of dietary phytoestrogens by Dutch women. PubMed: Quantification of the group B soyasaponins by high-performance liquid chromatography. PubMed: Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham study(1-4). PubMed: Quantitative determination of isoflavones and coumestrol in soybean by column liquid chromatography. PubMed: Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States). PubMed: LC-ESI-MS study of the flavonoid glycoside malonates of red clover (Trifolium pratense). PubMed: Synthesis of haptens and conjugates for ELISAs of phytoestrogens. Development of the immunological tests. PubMed: Development of a simple method for the determination of genistein, daidzein, biochanin A, and formononetin (biochanin B) in human urine. PubMed: Phytoestrogen content of purified, open- and closed-formula laboratory animal diets. PubMed: Phytoestrogen content in foods. PubMed: Isoflavones in human breast milk and other biological fluids. PubMed: Phytoestrogens have agonistic and combinatorial effects on estrogen-responsive gene expression in MCF-7 human breast cancer cells. PubMed: Isoflavone content of infant foods and formulas. PubMed: Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. PubMed: Phytoestrogen content of foods--a compendium of literature values. PubMed: Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine. PubMed: High-performance liquid chromatographic analysis of phytoestrogens in soy protein preparations with ultraviolet, electrochemical and thermospray mass spectrometric detection. PubMed: Oestrogenic activity of soya-bean products. PubMed: Phytoestrogens: adverse effects on reproduction in California quail.