fraxidin
2H-1-benzopyran-2-one, 8-hydroxy-6,7-dimethoxy-
Identification
| Name | fraxidin |
| IUPAC | 8-hydroxy-6,7-dimethoxychromen-2-one |
| CAS Number | 525-21-3 |
| EINECS | 208-370-7 |
| FDA UNII | Search |
| Molecular Formula | C11 H10 O5 |
| Molecular Weight | 222.19670000 |
| MDL Number | MFCD00017492 |
| Nikkaji Number | J11.697A |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 424.00 to 425.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 340.00 °F. TCC ( 171.00 °C. ) (est) |
| logP (o/w) | 0.793 (est) |
| Soluble in | water, 1.462e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for fraxidin usage levels up to | not for fragrance use. |
| Recommendation for fraxidin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2H-1-
benzopyran-2-one, 8-hydroxy-6,7-dimethoxy-
8-
hydroxy-6,7-dimethoxy-2-benzopyrone
8-
hydroxy-6,7-dimethoxychromen-2-one
PubMed:
Development of a highly visual, simple, and rapid test for the discovery of novel insulin mimetics in living vertebrates.
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Chemical constituents of Allophylus longipes.
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Constituents of the root of Anemone tomentosa.
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Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.
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Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells.
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[Studies on chemical constituents and antibacterial activity from n-butanol extract of Sarcandra glabra].
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Development of a rapid and validated method for investigating the metabolism of scoparone in rat using ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry.
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Secondary metabolites from the wood bark of Durio zibethinus and Durio kutejensis.
PubMed:
Metabolic fate of fraxin administered orally to rats.
PubMed:
Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress.
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Cytotoxic constituents of the twigs of Simarouba glauca collected from a plot in Southern Florida.
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Four new coumarin derivatives from Artemisia keiskeana.
PubMed:
Antihyperglycemic activity of Teramnus labialis (Fabaceae).
PubMed:
In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla.
PubMed:
Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins.