7,8-dihydroxyflavone

4H-1- benzopyran-4-one, 7,8-dihydroxy-2-phenyl- 7,8- dihydroxy-2-phenyl-4-benzopyrone 7,8- dihydroxy-2-phenyl-4H-1-benzopyran-4-one 7,8- dihydroxy-2-phenyl-4H-chromen-4-one 7,8- dihydroxy-2-phenyl-chromen-4-one 7,8- dihydroxy-2-phenylchromen-4-one 7,8- dihydroxy-flavone PubMed: 7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome. PubMed: Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor. PubMed: 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cell death through modulating PI3K/Akt and JNK pathways. PubMed: Behavior of the potential antitumor V(IV)O complexes formed by flavonoid ligands. 1. Coordination modes and geometry in solution and at the physiological pH. PubMed: Methylation and subsequent glycosylation of 7,8-dihydroxyflavone. PubMed: Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference. PubMed: Small-molecule TrkB agonist 7,8-dihydroxyflavone reverses cognitive and synaptic plasticity deficits in a rat model of schizophrenia. PubMed: 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. PubMed: 7,8-Dihydroxyflavone, a small molecule TrkB agonist, improves spatial memory and increases thin spine density in a mouse model of Alzheimer disease-like neuronal loss. PubMed: Effect of 7, 8-dihydroxyflavone on the up-regulation of Nrf2-mediated heme oxygenase-1 expression in hamster lung fibroblasts. PubMed: 7,8-Dihydroxyflavone attenuates the release of pro-inflammatory mediators and cytokines in lipopolysaccharide-stimulated BV2 microglial cells through the suppression of the NF-κB and MAPK signaling pathways. PubMed: 7,8-Dihydroxyflavone protects human keratinocytes against oxidative stress-induced cell damage via the ERK and PI3K/Akt-mediated Nrf2/HO-1 signaling pathways. PubMed: Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. PubMed: Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. PubMed: 7,8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction. PubMed: Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone. PubMed: Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity. PubMed: Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: radiosynthesis and evaluation of 2-(4-[(18)F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-(11)C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one. PubMed: 7,8-Dihydroxyflavone suppresses oxidative stress-induced base modification in DNA via induction of the repair enzyme 8-oxoguanine DNA glycosylase-1. PubMed: Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. PubMed: 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice. PubMed: 7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats. PubMed: Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves. PubMed: 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. PubMed: 7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine. PubMed: Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists. PubMed: Small molecules activating TrkB receptor for treating a variety of CNS disorders. PubMed: Individual differences in novelty seeking predict subsequent vulnerability to social defeat through a differential epigenetic regulation of brain-derived neurotrophic factor expression. PubMed: Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs. PubMed: Thyroxin treatment protects against white matter injury in the immature brain via brain-derived neurotrophic factor. PubMed: Probing the ability of presynaptic tyrosine kinase receptors to regulate striatal dopamine dynamics. PubMed: Activation of BDNF signaling prevents the return of fear in female mice. PubMed: Effects of TrkB agonist 7,8-dihydroxyflavone on sensory gating deficits in mice after administration of methamphetamine. PubMed: Modulatory effects of the novel TrkB receptor agonist 7,8-dihydroxyflavone on synaptic transmission and intrinsic neuronal excitability in mouse visual cortex in vitro. PubMed: 7,8-Dihydroxyflavone leads to survival of cultured embryonic motoneurons by activating intracellular signaling pathways. PubMed: TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia. PubMed: Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington's disease. PubMed: O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. PubMed: Apoptosis induction of human leukemia U937 cells by 7,8-dihydroxyflavone hydrate through modulation of the Bcl-2 family of proteins and the MAPKs signaling pathway. PubMed: Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning. PubMed: Influence of glucose on the human serum albumin-flavone interaction and their antioxidant activity. PubMed: Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. PubMed: Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. PubMed: Companions reverse stressor-induced decreases in neurogenesis and cocaine conditioning possibly by restoring BDNF and NGF levels in dentate gyrus. PubMed: Activation of TrkB by 7,8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. PubMed: 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. PubMed: 7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation. PubMed: Fear extinction and BDNF: translating animal models of PTSD to the clinic. PubMed: 7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells. PubMed: The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. PubMed: 7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. PubMed: Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. PubMed: Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins. PubMed: 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. PubMed: Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. PubMed: Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. PubMed: Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. PubMed: 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. PubMed: Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. PubMed: A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. PubMed: Characterization of an O-methyltransferase from Streptomyces avermitilis MA-4680. PubMed: [Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase]. PubMed: A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. PubMed: Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. PubMed: Acidity of hydroxyl groups: an overlooked influence on antiradical properties of flavonoids. PubMed: Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. PubMed: Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone. PubMed: Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. PubMed: Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells. PubMed: Flavonoids: structural requirements for antiproliferative activity on breast cancer cells. PubMed: Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes. PubMed: Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II). PubMed: Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. PubMed: Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. PubMed: Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. PubMed: Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase. PubMed: Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids. PubMed: Effects of phenolic compounds on bromobenzene-mediated hepatotoxicity in mice. PubMed: Effect of various flavonoids on lysosomes subjected to an oxidative or an osmotic stress. PubMed: Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII.