tocopheryl nicotinate

vitamin E nicotinate

CAS: 43119-47-7 C35 H53 N O3 MW: 535.81201000

Identification

Nametocopheryl nicotinate
IUPAC[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate
CAS Number43119-47-7
EINECS256-101-7
FDA UNIIWI1J5UCY5C
Molecular FormulaC35 H53 N O3
Molecular Weight535.81201000
Nikkaji NumberJ291.082I
Beilstein0466142

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 649.02 °C. @ 760.00 mm Hg (est)
Flash Point 655.00 °F. TCC ( 346.30 °C. ) (est)
logP (o/w) 11.327 (est)
Soluble in water, 8.516e-009 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Oral/Parenteral Toxicityintramuscular-mouse LD50 > 1000 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 > 20000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants, skin conditioning
Recommendation for tocopheryl nicotinate usage levels up tonot for fragrance use.
Recommendation for tocopheryl nicotinate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

(2R-(2R*(4R*,8R*)))-3,4- dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl tridecyl)-2H-1-benzopyran-6-yl nicotinate [2R-2R*(4R*,8R*)]-3,4- dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol nicotinate juvela nicotinate 3- pyridinecarboxylic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester 3- pyridinecarboxylic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, (2R-(2R*(4R*,8R*)))- (2R-(2R*(4R*,8R*)))-3- pyridinecarboxylic acid, 3,4-dihydro-2,5,7,8tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester (2R)-2,5,7,8- tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl nicotinate (2R)-2,5,7,8- tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl pyridine-3-carboxylate [(2R)-2,5,7,8- tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate DL-a- tocopherol nicotinate (2R)-2-((4R,8R)-4,8,12- trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-yl pyridine-3-carboxylate vitamin E nicotinate vitamin E nicotinic acid ester PubMed: Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan. PubMed: Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of alpha-tocopheryl esters. PubMed: Allergic contact dermatitis due to DL-alpha-tocopheryl nicotinate. PubMed: Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. PubMed: Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan. PubMed: Enhancement by alpha-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-gamma through the upregulation of protein kinase C in rat vascular smooth muscle cells. PubMed: Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia. PubMed: A randomised, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy. PubMed: Hydrolysis of tocopheryl and retinyl esters by porcine carboxyl ester hydrolase is affected by their carboxylate moiety and bile acids. PubMed: Reduction of tablet coloration at tableting for oily medicine (tocopheryl nicotinate). PubMed: Application of calcium silicate for medicinal preparation. I. Solid preparation adsorbing an oily medicine to calcium silicate. PubMed: Tissue alpha-tocopherol concentrations following supplementation with various forms of vitamin E in sheep. PubMed: [The significance of lipoprotein(a) in assessment of risk for atherosclerosis]. PubMed: Protection against carbon tetrachloride-induced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol. PubMed: Effects of dietary vitamin E on clinical course and plasma glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities in hereditary hepatitis of LEC rats. PubMed: Serum total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in lambs following supplementation with various forms of tocopherol. PubMed: Vitamin E and cancer prevention: recent advances and future potentials. PubMed: Bioavailability of vitamin E compounds in lambs. PubMed: High-performance liquid chromatographic determination of alpha-tocopheryl nicotinate in cosmetic preparations. PubMed: A prevention trial on cerebral infarction with dl-alpha-tocopheryl nicotinate--rationales for trial. The Alpha-Tocopheryl Nicotinate Prevention Study Group. PubMed: Reduction of serum lipoprotein(a) levels in hyperlipidaemic patients with alpha-tocopheryl nicotinate. PubMed: Effects of vitamin E administration on platelet function in diabetes mellitus. PubMed: Effects of dietary vitamin E supplement on gracile axonal dystrophy (gad) mice. PubMed: A nutritional evaluation of vitamin E status in very low birth weight infants with respect to changes in plasma and red blood cell tocopherol levels. PubMed: Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells. PubMed: Influence of vitamin E on platelet survival. PubMed: Effect of vitamin E on IgE antibody formation in mice. PubMed: Metabolism of the nicotinic acid moiety of d,l-alpha-tocopheryl nicotinate. PubMed: [Clinical effect of dentifrice containing dl-alpha-Tocopheryl nicotinate]. PubMed: [A case with Bartter's syndrome associated with type II hyperlipidemia, increased fluidity of plasma VLDL and abnormal configuration of peripheral erythrocytes (author's transl)]. PubMed: [Effects of soysterol, pantethine and dl-alpha-tocopheryl nicotinate on hyperlipemia in rats (author's transl)]. PubMed: The effect of food on the absorption of alpha-tocopheryl nicotinate in beagle dogs and human volunteers. PubMed: Cutaneous microcirculatory effects of various vasodilator agents on the conscious rabbit, with special regard to changes in the rhythmic property of vasomotion. PubMed: Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma. PubMed: Antihypertensive action of d,l-alpha-tocopheryl nicotinate in rats. PubMed: Inhibition of platelet aggregation by alpha-tocopherol and its nicotinate and acetate esters. PubMed: Effects of dl-alpha-tocopheryl nicotinate on coronary circulation and development of coronary collateral vessels. PubMed: Comparative double-blind trial of dl-alpha-tocopheryl nicotinate on vibration disease. PubMed: A controlled, double-blind study of dl-alpha-tocopheryl nicotinate (Juvela-Nicotinate) for treatment of symptoms in hypertension and cerebral arteriosclerosis. PubMed: Phagocytosis of alpha-tocopheryl nicotinate by the reticuloendothelial system: a microautoradiographic study. PubMed: Anti-hypertensive action of DL-alpha-tocopharyl esters in rats. PubMed: Comparison of alpha-tocopheryl nicotinate and acetate on skin microcirculation. PubMed: Comparative studies of the effects of alpha-tocopheryl nicotinate and the combination alpha-tocopheryl acetate and nicotinic acid. PubMed: Tissue uptake and metabolism of d,l-3,4- 3 H 2 -a-tocopheryl nicotinate and d,l-a-tocopheryl-1',2'- 3 H 2 -acetate following intravenous administration.