tocopheryl nicotinate
vitamin E nicotinate
Identification
| Name | tocopheryl nicotinate |
| IUPAC | [(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate |
| CAS Number | 43119-47-7 |
| EINECS | 256-101-7 |
| FDA UNII | WI1J5UCY5C |
| Molecular Formula | C35 H53 N O3 |
| Molecular Weight | 535.81201000 |
| Nikkaji Number | J291.082I |
| Beilstein | 0466142 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 649.02 °C. @ 760.00 mm Hg (est) |
| Flash Point | 655.00 °F. TCC ( 346.30 °C. ) (est) |
| logP (o/w) | 11.327 (est) |
| Soluble in | water, 8.516e-009 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intramuscular-mouse LD50 > 1000 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 > 20000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antioxidants, skin conditioning |
| Recommendation for tocopheryl nicotinate usage levels up to | not for fragrance use. |
| Recommendation for tocopheryl nicotinate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(2R-(2R*(4R*,8R*)))-3,4-
dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl tridecyl)-2H-1-benzopyran-6-yl nicotinate
[2R-2R*(4R*,8R*)]-3,4-
dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol nicotinate
juvela nicotinate
3-
pyridinecarboxylic acid, (2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl ester
3-
pyridinecarboxylic acid, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester, (2R-(2R*(4R*,8R*)))-
(2R-(2R*(4R*,8R*)))-3-
pyridinecarboxylic acid, 3,4-dihydro-2,5,7,8tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester
(2R)-2,5,7,8-
tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl nicotinate
(2R)-2,5,7,8-
tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl pyridine-3-carboxylate
[(2R)-2,5,7,8-
tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate
DL-a-
tocopherol nicotinate
(2R)-2-((4R,8R)-4,8,12-
trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-yl pyridine-3-carboxylate
vitamin E nicotinate
vitamin E nicotinic acid ester
PubMed:
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed:
Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of alpha-tocopheryl esters.
PubMed:
Allergic contact dermatitis due to DL-alpha-tocopheryl nicotinate.
PubMed:
Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review.
PubMed:
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed:
Enhancement by alpha-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-gamma through the upregulation of protein kinase C in rat vascular smooth muscle cells.
PubMed:
Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia.
PubMed:
A randomised, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy.
PubMed:
Hydrolysis of tocopheryl and retinyl esters by porcine carboxyl ester hydrolase is affected by their carboxylate moiety and bile acids.
PubMed:
Reduction of tablet coloration at tableting for oily medicine (tocopheryl nicotinate).
PubMed:
Application of calcium silicate for medicinal preparation. I. Solid preparation adsorbing an oily medicine to calcium silicate.
PubMed:
Tissue alpha-tocopherol concentrations following supplementation with various forms of vitamin E in sheep.
PubMed:
[The significance of lipoprotein(a) in assessment of risk for atherosclerosis].
PubMed:
Protection against carbon tetrachloride-induced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol.
PubMed:
Effects of dietary vitamin E on clinical course and plasma glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities in hereditary hepatitis of LEC rats.
PubMed:
Serum total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in lambs following supplementation with various forms of tocopherol.
PubMed:
Vitamin E and cancer prevention: recent advances and future potentials.
PubMed:
Bioavailability of vitamin E compounds in lambs.
PubMed:
High-performance liquid chromatographic determination of alpha-tocopheryl nicotinate in cosmetic preparations.
PubMed:
A prevention trial on cerebral infarction with dl-alpha-tocopheryl nicotinate--rationales for trial. The Alpha-Tocopheryl Nicotinate Prevention Study Group.
PubMed:
Reduction of serum lipoprotein(a) levels in hyperlipidaemic patients with alpha-tocopheryl nicotinate.
PubMed:
Effects of vitamin E administration on platelet function in diabetes mellitus.
PubMed:
Effects of dietary vitamin E supplement on gracile axonal dystrophy (gad) mice.
PubMed:
A nutritional evaluation of vitamin E status in very low birth weight infants with respect to changes in plasma and red blood cell tocopherol levels.
PubMed:
Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells.
PubMed:
Influence of vitamin E on platelet survival.
PubMed:
Effect of vitamin E on IgE antibody formation in mice.
PubMed:
Metabolism of the nicotinic acid moiety of d,l-alpha-tocopheryl nicotinate.
PubMed:
[Clinical effect of dentifrice containing dl-alpha-Tocopheryl nicotinate].
PubMed:
[A case with Bartter's syndrome associated with type II hyperlipidemia, increased fluidity of plasma VLDL and abnormal configuration of peripheral erythrocytes (author's transl)].
PubMed:
[Effects of soysterol, pantethine and dl-alpha-tocopheryl nicotinate on hyperlipemia in rats (author's transl)].
PubMed:
The effect of food on the absorption of alpha-tocopheryl nicotinate in beagle dogs and human volunteers.
PubMed:
Cutaneous microcirculatory effects of various vasodilator agents on the conscious rabbit, with special regard to changes in the rhythmic property of vasomotion.
PubMed:
Decreased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the blood and its unresponsiveness to tocophreyl nicotinate and indomethacin in patients with primary hepatocellular carcinoma.
PubMed:
Antihypertensive action of d,l-alpha-tocopheryl nicotinate in rats.
PubMed:
Inhibition of platelet aggregation by alpha-tocopherol and its nicotinate and acetate esters.
PubMed:
Effects of dl-alpha-tocopheryl nicotinate on coronary circulation and development of coronary collateral vessels.
PubMed:
Comparative double-blind trial of dl-alpha-tocopheryl nicotinate on vibration disease.
PubMed:
A controlled, double-blind study of dl-alpha-tocopheryl nicotinate (Juvela-Nicotinate) for treatment of symptoms in hypertension and cerebral arteriosclerosis.
PubMed:
Phagocytosis of alpha-tocopheryl nicotinate by the reticuloendothelial system: a microautoradiographic study.
PubMed:
Anti-hypertensive action of DL-alpha-tocopharyl esters in rats.
PubMed:
Comparison of alpha-tocopheryl nicotinate and acetate on skin microcirculation.
PubMed:
Comparative studies of the effects of alpha-tocopheryl nicotinate and the combination alpha-tocopheryl acetate and nicotinic acid.
PubMed:
Tissue uptake and metabolism of d,l-3,4- 3 H 2 -a-tocopheryl nicotinate and d,l-a-tocopheryl-1',2'- 3 H 2 -acetate following intravenous administration.