evernic acid
4-((4-methoxy-6-methylsalicyloyl)oxy)-6-methylsalicylic acid
Identification
| Name | evernic acid |
| IUPAC | 2-hydroxy-4-(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy-6-methylbenzoic acid |
| CAS Number | 537-09-7 |
| EINECS | 208-658-2 |
| FDA UNII | 2EQ5W5403J |
| Molecular Formula | C17 H16 O7 |
| Molecular Weight | 332.30892000 |
| MDL Number | MFCD00045824 |
| Nikkaji Number | J13.675A |
| Beilstein | 2227186 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 531.80 °C. @ 760.00 mm Hg (est) |
| Flash Point | 382.00 °F. TCC ( 194.60 °C. ) (est) |
| logP (o/w) | 5.030 (est) |
| Soluble in | water, 4.404 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intravenous-mouse LD50 178 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01633']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for evernic acid usage levels up to | not for fragrance use. |
| Recommendation for evernic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4-((4-
methoxy-6-methyl salicyloyl)oxy)-6-methyl salicylic acid
2,6-
cresotic acid, 4-methoxy-, 4-ester with 6-methyl-beta-resorcylic acid (8CI)
4-((4-
methoxy-6-methylsalicyloyl)oxy)-6-methylsalicylic acid
2-
hydroxy-4-(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy-6-methylbenzoic acid
2-
hydroxy-4-[(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy]-6-methylbenzoic acid
PubMed:
Clastogenic effect of atranorin, evernic acid, and usnic acid on human lymphocytes.
PubMed:
[Study on the chemical constituents of two lichen plants from Meng Mountain].
PubMed:
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.
PubMed:
Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds.
PubMed:
Fragrance chemicals in domestic and occupational products.
PubMed:
Improvement of the analysis of dansylated derivatives of polyamines and their conjugates by high-performance liquid chromatography.
PubMed:
Separation of polyamines, conjugated to DNA, by reversed-phase high-performance liquid chromatography.
PubMed:
Screening of tissue cultures and thalli of lichens and some of their active constituents for inhibition of tumor promoter-induced Epstein-Barr virus activation.
PubMed:
An investigation of the allergenic constituents of Cladonia stellaris (Opiz) Pous & Vezda ('silver moss', 'reindeer moss' or 'reindeer lichen').
PubMed:
The occurrence of lichen phenolics in the photobiont cells of Evernia prunastri.
PubMed:
Photosensitivity to oak moss.
PubMed:
The use of immobilized cells to stabilize orsellinate depside hydrolase of Pseudevernia furfuracea.
PubMed:
Purification and Properties of the Constitutive Arginase of Evernia prunastri.
PubMed:
The use of urea by Evernia prunastri thalli.
PubMed:
A Simple Assay Demonstrating the Effect of Rehydration on the Orsellinate Depside Hydrolase Activity of Evernia prunastri.
PubMed:
Endogenous Inactivators of Arginase, l-Arginine Decarboxylase, and Agmatine Amidinohydrolase in Evernia prunastri Thallus.
PubMed:
Contact allergy to atranorin in lichens and perfumes.