pterosin B
(R)-6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one
Identification
| Name | pterosin B |
| IUPAC | (2R)-6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydroinden-1-one |
| CAS Number | 34175-96-7 |
| FDA UNII | Search |
| Molecular Formula | C14 H18 O2 |
| Molecular Weight | 218.29586000 |
| Nikkaji Number | J2.774J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 212.8 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for pterosin B usage levels up to | not for fragrance use. |
| Recommendation for pterosin B flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(R)-6-(2-
hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one
(2R)-6-(2-
hydroxyethyl)-2,5,7-trimethyl-2,3-dihydroinden-1-one
1-
indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-
1H-
inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (R)-
PubMed:
Survey of ferns and clinico-pathological studies on the field cases of Enzootic bovine haematuria in Himachal Pradesh, a north-western Himalayan state of India.
PubMed:
Screening for Ptaquiloside in Ferns: Using Herbarium Specimens for Qualitative Mapping Purposes.
PubMed:
Bovine enzootic haematuria from consumption of Pteris deflexa and Pteris plumula in northwestern Argentina.
PubMed:
UPLC-MS/MS determination of ptaquiloside and pterosin B in preserved natural water.
PubMed:
Dissipation of pterosin B in acid soils - Tracking the fate of the bracken fern carcinogen ptaquiloside.
PubMed:
Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
PubMed:
Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome.
PubMed:
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
PubMed:
Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling.
PubMed:
Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes.
PubMed:
Evaluation of the anti-inflammatory and antioxidative potential of four fern species from China intended for use as food supplements.
PubMed:
Determination of ptaquiloside and pterosin B derived from bracken (Pteridium aquilinum) in cattle plasma, urine and milk.
PubMed:
The naturally occurring carcinogen ptaquiloside is present in groundwater below bracken vegetation.
PubMed:
Influence of bracken fern (Pteridium caudatum L. Maxon) pre-treatment on extraction yield of illudane glycosides and pterosins.
PubMed:
A new facile synthesis of dâ-pterosin B and dâ-bromopterosin, deuterated analogues of ptaquiloside.
PubMed:
Metabolism of (2S)-pterosin A: identification of the phase I and phase II metabolites in rat urine.
PubMed:
Residue potential of norsesquiterpene glycosides in tissues of cattle fed Austral bracken (Pteridium esculentum).
PubMed:
Norsesquiterpene glycosides in bracken ferns (Pteridium esculentum and Pteridium aquilinum subsp. wightianum) from Eastern Australia: reassessed poisoning risk to animals.
PubMed:
Quantification of ptaquiloside and pterosin B in soil and groundwater using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
PubMed:
Isolation of 5-hydroxypyrrolidin-2-one and other constituents from the young fronds of Pteridium aquilinum.
PubMed:
New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis Burm.
PubMed:
Characterization of toxin from cheilanthes fern and its effect on lymphocyte proliferation and DNA fragmentation.