beta-lapachone

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2H-naphthol[1,2-b]pyan-5,6-dione, 3,4-dihydro-2,2-dimethyl-

CAS: 4707-32-8 C15 H14 O3 MW: 242.27418000

Identification

Namebeta-lapachone
IUPAC2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione
CAS Number4707-32-8
FDA UNII6N4FA2QQ6A
Molecular FormulaC15 H14 O3
Molecular Weight242.27418000
MDL NumberMFCD01712233
Beilstein0181499

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 381.40 °C. @ 760.00 mm Hg (est)
Flash Point 337.00 °F. TCC ( 169.70 °C. ) (est)
logP (o/w) 2.820 (est)
Soluble in water, 48.47 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial agents
Recommendation for beta-lapachone usage levels up tonot for fragrance use.
Recommendation for beta-lapachone flavor usage levels up tonot for flavor use.

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4707-32-8 beta-Lapachone > 98%
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Potential Uses

None Found

Natural Occurrence

tabebuia avellanedae

Synonyms

3,4- dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione 2,2- dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione lapachone 2H- naphthol[1,2-b]pyan-5,6-dione, 3,4-dihydro-2,2-dimethyl- PubMed: Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice. PubMed: Beta-lapachone (LAPA) decreases cell viability and telomerase activity in leukemia cells: suppression of telomerase activity by LAPA. PubMed: Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase. PubMed: Toxic potential of dietary genistein isoflavone and beta-lapachone on capacitation and acrosome reaction of epididymal spermatozoa.