arnebin 1
beta,beta-dimethylacrylshikonin
Identification
| Name | arnebin 1 |
| IUPAC | [1-(5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] 3-methylbut-2-enoate |
| CAS Number | 5162-01-6 |
| FDA UNII | Search |
| Molecular Formula | C21 H22 O6 |
| Molecular Weight | 370.40154000 |
| Nikkaji Number | J256.532C |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.1685 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for arnebin 1 usage levels up to | not for fragrance use. |
| Recommendation for arnebin 1 flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
arnebin I
2-
butenoic acid, 3-methyl-, 1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-pentenyl ester
[1-(5,8-
dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl] 3-methylbut-2-enoate
beta,beta-
dimethyl acryl shikonin
beta,beta-
dimethylacrylshikonin
PubMed:
Glucose uptake stimulatory potential and antidiabetic activity of the Arnebin-1 from Arnabia nobelis.
PubMed:
Phytochemicals in Wound Healing.
PubMed:
Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.
PubMed:
Arnebin-1 promotes the angiogenesis of human umbilical vein endothelial cells and accelerates the wound healing process in diabetic rats.
PubMed:
Estimation of naphthaquinones from Arnebia hispidissima (Lehm.) DC. In vivo and in vitro. I. Anti-inflammatory screening.
PubMed:
Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing.