methysticin

(R-(E))-6-(2-(1,3- benzodioxol-5-yl)ethenyl)-5,6-dihydro-4-methoxy-2H-pyran-2-one (2R)-2-[(E)-2-(1,3- benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one (R)-5,6- dihydro-4-methoxy-6-(3,4-(methylene dioxy)styryl)-2H-pyran-2-one 5- hydroxy-3-methoxy-7-(3,4-(methylenedioxy)phenyl)-2,6-heptadienoic acid gamma-lactone kavahin kavatin 2H- pyran-2-one, 5,6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)styryl)-, (R)- PubMed: Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. PubMed: Quantitative Determination of Lactones in Piper methysticum (Kava-Kava) by Supercritical Fluid Chromatography. PubMed: Kavalactone content and chemotype of kava beverages prepared from roots and rhizomes of Isa and Mahakea varieties and extraction efficiency of kavalactones using different solvents. PubMed: Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors. PubMed: Phototoxicity of kava - formation of reactive oxygen species leading to lipid peroxidation and DNA damage. PubMed: Kavalactone metabolism in rat liver microsomes. PubMed: Pacific island 'Awa (Kava) extracts, but not isolated kavalactones, promote proinflammatory responses in model mast cells. PubMed: Kavalactone metabolism in the isolated perfused rat liver. PubMed: Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice. PubMed: Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. PubMed: Proposal for a kava quality standardization code. PubMed: Herbal bioactivation, molecular targets and the toxicity relevance. PubMed: Kavalactones Yangonin and Methysticin induce apoptosis in human hepatocytes (HepG2) in vitro. PubMed: Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. PubMed: Highly regio- and stereoselective Heck reaction of allylic esters with arenediazonium salts: application to the synthesis of kavalactones. PubMed: Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity. PubMed: High-performance liquid chromatography assays for desmethoxyyangonin, methysticin, kavain and their microsomal metabolites. PubMed: Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots. PubMed: Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. PubMed: Evaluation of commercial kava extracts and kavalactone standards for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells. PubMed: Permeability studies of Kavalactones using a Caco-2 cell monolayer model. PubMed: Fourier transform ion cyclotron resonance mass spectrometry for the characterisation of kavalactones in the kava plant: elemental formulae confirmation by dual spray accurate mass measurement and structural confirmation by infrared multiphoton dissociation and sustained off-resonance irradiation collision induced dissociation. PubMed: Melanogenesis stimulation in murine B16 melanoma cells by Kava (Piper methysticum) rhizome extract and kavalactones. PubMed: Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). PubMed: Kavalactones fail to inhibit alcohol dehydrogenase in vitro. PubMed: Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation. PubMed: Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. PubMed: Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro. PubMed: Superheated water chromatography-nuclear magnetic resonance spectroscopy of kava lactones. PubMed: Determination of kava lactones in food supplements by liquid chromatography-atmospheric pressure chemical ionisation tandem mass spectrometry. PubMed: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard. PubMed: LC-UV and LC-MS analysis of food and drink products containing kava. PubMed: Analysis of kavalactones from Piper methysticum (kava-kava). PubMed: Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. PubMed: Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. PubMed: Kava does not display metabolic toxicity in a homogeneous cellular assay. PubMed: Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). PubMed: Inhibition of human cytochrome P450 activities by kava extract and kavalactones. PubMed: Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity. PubMed: Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots. PubMed: Interaction of various Piper methysticum cultivars with CNS receptors in vitro. PubMed: Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm. PubMed: Microbial transformation of kawain and methysticin. PubMed: Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). PubMed: Effect of kava extract and individual kavapyrones on neurotransmitter levels in the nucleus accumbens of rats. PubMed: Influence of genuine kavapyrone enantiomers on the GABA-A binding site. PubMed: Contribution to the quantitative and enantioselective determination of kavapyrones by high-performance liquid chromatography on ChiraSpher NT material. PubMed: Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. PubMed: Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract. PubMed: Piper methysticum: enantiomeric separation of kavapyrones by high performance liquid chromatography. PubMed: Effects of methysticin on three different models of seizure like events studied in rat hippocampal and entorhinal cortex slices. PubMed: Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. PubMed: The antinociceptive actions of kava components in mice. PubMed: Metabolism of some kava pyrones in the rat. PubMed: [Quantitative determination of kawa lactones in Piper methysticum (Forster). 2. Determination of kawain, methysticin and yangonin]. PubMed: [Quantitative determination of kawa-lactones in Piper methysticum (Forster). 1. Determination methods with pure substances kawain, methysticin and yangonin].