ginkgetin
ginkgetin 7''-O-b-D-glucopyranoside
Identification
| Name | ginkgetin |
| CAS Number | 481-46-9 |
| FDA UNII | HY5EZW8269 |
| Molecular Formula | C32 H22 O10 |
| Molecular Weight | 566.51934000 |
| Nikkaji Number | J92.485G |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 863.70 °C. @ 760.00 mm Hg (est) |
| Flash Point | 549.00 °F. TCC ( 287.20 °C. ) (est) |
| logP (o/w) | 4.450 (est) |
| Soluble in | water, 0.002419 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ginkgetin usage levels up to | not for fragrance use. |
| Recommendation for ginkgetin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4H-1-
benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-
3''',8-
biflavone, 4',5,5'',7-tetrahydroxy-4''',7''-dimethoxy-
5,7-
dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl)-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
5,7-
dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-chromen-4-one
5,7-
dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one
7,4'-
dimethyl amentoflavone
7,4'-
dimethylamentoflavone
ginkgetin 7''-O-b-D-glucopyranoside
PubMed:
Neuroprotective biflavonoids of Chamaecyparis obtusa leaves against glutamate-induced oxidative stress in HT22 hippocampal cells.
PubMed:
Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells.
PubMed:
Two new nonacosanetriols from Ginkgo biloba sarcotesta.
PubMed:
Biflavonoids from Caper (Capparis spinosa L.) fruits and their effects in inhibiting NF-kappa B activation.
PubMed:
Target-guided isolation and purification of antioxidants from Selaginella sinensis by offline coupling of DPPH-HPLC and HSCCC experiments.
PubMed:
A new dilactone from the seeds of Gaultheria yunnanensis.
PubMed:
[Structrue identification of biflavones and determination of Taxol from Taxus Madia].
PubMed:
Inhibition of arachidonate release from rat peritoneal macrophage by biflavonoids.
PubMed:
Biochemical pharmacology of biflavonoids: implications for anti-inflammatory action.
PubMed:
Seco-terpenoids and other constituents from Elateriospermum tapos.
PubMed:
Anti-inflammatory activity of the synthetic C-C biflavonoids.
PubMed:
Anti-influenza virus activity of biflavonoids.
PubMed:
Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation.
PubMed:
Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).
PubMed:
Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana.
PubMed:
Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba.
PubMed:
Comparative antiplasmodial, leishmanicidal and antitrypanosomal activities of several biflavonoids.
PubMed:
Ginkgetin, a Biflavone from Ginko biloba leaves, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells.
PubMed:
Biflavones from Chamaecyparis obtusa.
PubMed:
Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation.
PubMed:
Biflavone glucosides from Ginkgo biloba yellow leaves.
PubMed:
Neuroprotective effects of naturally occurring biflavonoids.
PubMed:
Flavonoids from Metasequoia glyptostroboides.
PubMed:
[The effects of ginaton on cochlear microcirculation].
PubMed:
Antifungal activity of biflavones from Taxus baccata and Ginkgo biloba.
PubMed:
Flavonoids differentially inhibit guinea pig epidermal cytosolic phospholipase A2.
PubMed:
Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation.
PubMed:
Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes.
PubMed:
Effect of biflavones of Ginkgo biloba against UVB-induced cytotoxicity in vitro.
PubMed:
Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7.
PubMed:
Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell line.
PubMed:
The effects of two new antagonists of secretory PLA2 on TNF, iNOS, and COX-2 expression in activated macrophages.
PubMed:
Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.
PubMed:
Inhibition of cAMP-phosphodiesterase by biflavones of Ginkgo biloba in rat adipose tissue.
PubMed:
Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs.
PubMed:
[HPLC determination of six flavonoid constituents in Ginkgo biloba leaves].
PubMed:
Selective cytotoxicity of ginkgetin from Selaginella moellendorffii.
PubMed:
Effects of flavonoids of Ginkgo biloba on proliferation of human skin fibroblast.
PubMed:
Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids.
PubMed:
Mechanism of action of the antiherpesvirus biflavone ginkgetin.
PubMed:
Effects of some compounds isolated fromCelaenodendron mexicanum standl (euphorbiaceae) on seeds and phytopathogenic fungi.
PubMed:
HPLC Separation and Quantitative Determination of Biflavones in Leaves from Ginkgo biloba.