1,2-cyclohexane diol

2-hydroxycyclohexanol

CAS: 931-17-9 C6 H12 O2 MW: 116.16004000

Identification

Name1,2-cyclohexane diol
CAS Number931-17-9
EINECS213-229-8
FDA UNIISearch
Molecular FormulaC6 H12 O2
Molecular Weight116.16004000
MDL NumberMFCD00003861
Nikkaji NumberJ39.508K
Beilstein2036627

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 6.592e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for 1,2-cyclohexane diol usage levels up tonot for fragrance use.
Recommendation for 1,2-cyclohexane diol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

castoreum PMC

Synonyms

brenzcatechin cyclohexane-1,2-diol 1,2- cyclohexanediol 1,2- dihydroxycyclohexane 2- hydroxycyclohexanol PubMed: Practical synthesis of the C-ring precursor of paclitaxel from 3-methoxytoluene. PubMed: A Mild Catalytic Oxidation System: FePcOTf/H2O2 Applied for Cyclohexene Dihydroxylation. PubMed: Encapsulation of enzyme via one-step template-free formation of stable organic-inorganic capsules: A simple and efficient method for immobilizing enzyme with high activity and recyclability. PubMed: A simple and convenient approach for preparing core-shell-like silica@nickel species nanoparticles: highly efficient and stable catalyst for the dehydrogenation of 1,2-cyclohexanediol to catechol. PubMed: Effect of hydroxyl groups and rigid structure in 1,4-cyclohexanediol on percutaneous absorption of metronidazole. PubMed: Isolation, characterization, and nuclease activity of biologically relevant chromium(V) complexes with monosaccharides and model diols. Likely intermediates in chromium-induced cancers. PubMed: Assessment of the nuclear pore dilating agent trans-cyclohexane-1,2-diol in differentiated airway epithelium. PubMed: Structural organization of the nuclear pore permeability barrier. PubMed: Contribution of flavonoids and catechol to the reduction of ICAM-1 expression in endothelial cells by a standardised Willow bark extract. PubMed: Cyclohexane-1,2-dione hydrolase from denitrifying Azoarcus sp. strain 22Lin, a novel member of the thiamine diphosphate enzyme family. PubMed: Theoretical study of oxidation of cyclohexane diol to adipic anhydride by [Ru(IV)(O)(tpa)(H2O)]2+ complex (tpa ═ tris(2-pyridylmethyl)amine). PubMed: Theoretical insights into heme-catalyzed oxidation of cyclohexane to adipic acid. PubMed: Exceptional structural and mechanical flexibility of the nuclear pore complex. PubMed: A very active cu-catalytic system for the synthesis of aryl, heteroaryl, and vinyl sulfides. PubMed: Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745. PubMed: On the origins of kinetic resolution of cyclohexane-1,2-diols through stereoselective acylation by chiral tetrapeptides. PubMed: Oxidation of cyclohexanediol derivatives with 12-tungstophosphoric acid-hydrogen peroxide system. PubMed: From simple diols to carbohydrate derivatives of phenylarsonic acid. PubMed: Oxidation of p-chlorotoluene and cyclohexene catalysed by polymer-anchored oxovanadium(IV) and copper(II) complexes of amino acid derived tridentate ligands. PubMed: New strategies for nucleic acid delivery to conquer cellular and nuclear membranes. PubMed: An interlaboratory comparison of methods used to assess antioxidant potentials. PubMed: An unexpected co-crystal with a variable degree of order: 1:1 rac-1,2-cyclohexanediol/triphenylphosphine oxide. PubMed: Advantages of synthesizing trans-1,2-cyclohexanediol in a continuous flow microreactor over a standard glass apparatus. PubMed: Is adamantane a suitable substituent to pre-organize the acid orientation in E-selectin antagonists? PubMed: Nuclear accumulation of plasmid DNA can be enhanced by non-selective gating of the nuclear pore. PubMed: Solid-state compounds of stereoisomers: cis and trans isomers of 1,2-cyclohexanediol and 2,3-tetralindiol. PubMed: Dovyalicin-type spermidine alkaloids from Dovyalis species. PubMed: Zr(IV)-monosubstituted Keggin-type dimeric polyoxometalates: synthesis, characterization, catalysis of H2O2-based oxidations, and theoretical study. PubMed: Hydrophobic and hydrophilic yoctowells. PubMed: Biocatalytic production of enantiopure cyclohexane-trans-1,2-diol using extracellular lipases from Bacillus subtilis. PubMed: Towards carbohydrate derivatives of the ReI(CO)3 fragment. PubMed: Preparation and evaluation of a chiral stationary phase covalently bound with chiral pseudo-1 8-crown-6 ether having 1-phenyl-1,2-cyclohexanediol as a chiral unit. PubMed: Determination of the mode and efficacy of the cross-linking of guar by borate using MAS 11B NMR of borate cross-linked guar in combination with solution 11B NMR of model systems. PubMed: Synthesis of a new oxime and its application to the construction of a highly selective and sensitive Co(II) PVC-based membrane sensor. PubMed: Absence of interactive effects of trans-1,2-cyclohexanediol, a major metabolite of the side-chain of candesartan cilexetil, on digoxin-induced arrhythmias in dogs. PubMed: Tin(II) chloride catalyzed reactions of diazodiphenylmethane with vicinal diols in an aprotic solvent. The reactions with cis- and trans-1,2-cyclohexanediols and 1,2-propanediol. PubMed: [Enantiomeric resolution of trans-1,2-disubstituted cyclopropane by high performance liquid chromatography]. PubMed: Chiral separation of enantiomeric 1,2-diamines using molecular imprinting method and selectivity enhancement by addition of achiral primary amines into eluents. PubMed: Electronic Effects in Asymmetric Catalysis: Structural Studies of Precatalysts and Intermediates in Rh-Catalyzed Hydrogenation of Dimethyl Itaconate and Acetamidocinnamic Acid Derivatives Using C(2)-Symmetric Diarylphosphinite Ligands. PubMed: Photoinitiated catalysis in Nafion membranes containing palladium(II) meso-tetrakis(N-methyl-4-pyridyl)porphyrin and iron(III) meso-tetrakis-(2,6-dichlorophenyl)porphyrin for O2-mediated oxidations of alkenes. PubMed: Expression of benzene dioxygenase from Pseudomonas putida ML2 in cis-1,2-cyclohexanediol-degrading pseudomonads. PubMed: Asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids using (S,S)-cyclohexane-1,2-diol as a chiral auxiliary. PubMed: Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol. PubMed: Stereochemical differentiation of cyclic glycols by ion-molecule reactions in a quadrupole mass spectrometer using dimethyl ether acetonitrile and 2-S-pyrrolidinemethanol PubMed: Effect of ethanol on the urinary excretion of cyclohexanol and cyclohexanediols, biomarkers of the exposure to cyclohexanone, cyclohexane and cyclohexanol in humans. PubMed: Biological monitoring of occupational exposure to cyclohexane by urinary 1,2- and 1,4-cyclohexanediol determination. PubMed: Monitoring of occupational exposure to cyclohexanone by diffusive sampling and urinalysis. PubMed: 1,2- and 1,4-Cyclohexanediol: major urinary metabolites and biomarkers of exposure to cyclohexane, cyclohexanone, and cyclohexanol in humans. PubMed: Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography. PubMed: Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse. PubMed: Simple and sensitive determination of 2,3-butanediol in biological samples by gas chromatography with electron-capture detection. PubMed: Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia. PubMed: Metabolism and disposition of cyclohexanone oxime in male F-344 rats. PubMed: Cyclohexane diester analogues of phorbol ester as potential activators of protein kinase C. PubMed: Urinary excretion of cyclohexanediol, a metabolite of the solvent cyclohexanone, by infants in a special care unit. PubMed: Saturated analogues of poison ivy allergens. Synthesis of trans,trans- and cis,trans-3-alkyl-1,2-cyclohexanediols and sensitizing properties in allergic contact dermatitis. PubMed: The role of arginyl residues in estrogen receptor activation and transformation. PubMed: Myo-inositol transport in Saccharomyces cerevisiae. PubMed: A study on the mutagenic activity of styrene and styrene oxide. PubMed: [Suitability of the O-diphenol oxidase test using catechol for the differentiation of Cryptococcus neoformans]. PubMed: The metabolites of cyclohexylamine in man and certain animals. PubMed: Comparison of metal-binding properties of trans-1,2-cyclohexanediol diphosphate and deacylated phosphoinositides. PubMed: Cis-Cyclohexane-1,2-diol in the beaver gland.