artemetin
combretol
Identification
| Name | artemetin |
| IUPAC | 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one |
| CAS Number | 479-90-3 |
| FDA UNII | 73KMT7R64H |
| Molecular Formula | C20 H20 O8 |
| Molecular Weight | 388.37300000 |
| Nikkaji Number | J12.181I |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 588.80 °C. @ 760.00 mm Hg (est) |
| Flash Point | 408.00 °F. TCC ( 208.90 °C. ) (est) |
| logP (o/w) | 2.550 (est) |
| Soluble in | water, 54.85 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for artemetin usage levels up to | not for fragrance use. |
| Recommendation for artemetin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
artemisetin
4H-1-
benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-
combretol
2-(3,4-
dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one
2-(3,4-
dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one
2-(3,4-
dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one
erianthin
flavone, 5-hydroxy-3,3',4',6,7-pentamethoxy-
5-
hydroxy-3,3',4',6,7-pentamethoxyflavone
5-
hydroxy-3,6,7,3',4'-pentamethoxyflavone
penta-O-methylquercetagetin
quercetagetin-3,6,7,3',4'-pentamethylether
PubMed:
In vitro Antitumoral Activity of Compounds Isolated from Artemisia gorgonum Webb.
PubMed:
Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells.
PubMed:
The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin.
PubMed:
[Chemical constituents from ethyl acetate extract of Artemisia rupestris].
PubMed:
Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction.
PubMed:
The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion.
PubMed:
Bioactive diterpenes from Callicarpa longissima.
PubMed:
Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats.
PubMed:
Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum.
PubMed:
Hypotensive mechanism of the extracts and artemetin isolated from Achillea millefolium L. (Asteraceae) in rats.
PubMed:
[Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography].
PubMed:
One new triterpene ester from Nepeta suavis.
PubMed:
Chemical composition and antibacterial activity of Cordia verbenacea extracts obtained by different methods.
PubMed:
A high-speed counter-current chromatography- HPLC-DAD method for preparative isolation and purification of two polymethoxylated flavones from Taraxacum mongolicum.
PubMed:
Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus.
PubMed:
Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines.
PubMed:
[Studies on chemical constituents from herbs of Taraxacum mongolicum].
PubMed:
[Studies on constitutes from Taraxacum mongolicum].
PubMed:
[Studies on chemical constituents in herb from Artemisia rupestris].
PubMed:
Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells.
PubMed:
Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia.
PubMed:
G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.).
PubMed:
Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC.
PubMed:
New diterpenes and norditerpenes from the fruits of Vitex rotundifolia.
PubMed:
In vitro cytotoxicity of flavonoids against MK2 and C6 tumour cells.
PubMed:
Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells.
PubMed:
Terpenoids and flavonoids from Artemisia species.
PubMed:
Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships.
PubMed:
Cytotoxic flavonoids from Vitex agnus-castus.
PubMed:
Cytotoxic terpenoids and flavonoids from Artemisia annua.
PubMed:
Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures.
PubMed:
Anti-inflammatory activity and sub-acute toxicity of artemetin.
PubMed:
Chemical Constituents of Buxus sempervirens.
PubMed:
Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones.
PubMed:
Isolation and identification of three new flavones from Achillea millefolium L.