artemetin

combretol

CAS: 479-90-3 C20 H20 O8 MW: 388.37300000

Identification

Nameartemetin
IUPAC2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one
CAS Number479-90-3
FDA UNII73KMT7R64H
Molecular FormulaC20 H20 O8
Molecular Weight388.37300000
Nikkaji NumberJ12.181I

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 588.80 °C. @ 760.00 mm Hg (est)
Flash Point 408.00 °F. TCC ( 208.90 °C. ) (est)
logP (o/w) 2.550 (est)
Soluble in water, 54.85 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for artemetin usage levels up tonot for fragrance use.
Recommendation for artemetin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

verbena yarrow

Synonyms

artemisetin 4H-1- benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy- combretol 2-(3,4- dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one 2-(3,4- dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-chromen-4-one 2-(3,4- dimethoxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one erianthin flavone, 5-hydroxy-3,3',4',6,7-pentamethoxy- 5- hydroxy-3,3',4',6,7-pentamethoxyflavone 5- hydroxy-3,6,7,3',4'-pentamethoxyflavone penta-O-methylquercetagetin quercetagetin-3,6,7,3',4'-pentamethylether PubMed: In vitro Antitumoral Activity of Compounds Isolated from Artemisia gorgonum Webb. PubMed: Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells. PubMed: The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin. PubMed: [Chemical constituents from ethyl acetate extract of Artemisia rupestris]. PubMed: Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction. PubMed: The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. PubMed: Bioactive diterpenes from Callicarpa longissima. PubMed: Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats. PubMed: Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. PubMed: Hypotensive mechanism of the extracts and artemetin isolated from Achillea millefolium L. (Asteraceae) in rats. PubMed: [Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography]. PubMed: One new triterpene ester from Nepeta suavis. PubMed: Chemical composition and antibacterial activity of Cordia verbenacea extracts obtained by different methods. PubMed: A high-speed counter-current chromatography- HPLC-DAD method for preparative isolation and purification of two polymethoxylated flavones from Taraxacum mongolicum. PubMed: Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus. PubMed: Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. PubMed: [Studies on chemical constituents from herbs of Taraxacum mongolicum]. PubMed: [Studies on constitutes from Taraxacum mongolicum]. PubMed: [Studies on chemical constituents in herb from Artemisia rupestris]. PubMed: Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells. PubMed: Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia. PubMed: G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). PubMed: Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC. PubMed: New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. PubMed: In vitro cytotoxicity of flavonoids against MK2 and C6 tumour cells. PubMed: Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. PubMed: Terpenoids and flavonoids from Artemisia species. PubMed: Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships. PubMed: Cytotoxic flavonoids from Vitex agnus-castus. PubMed: Cytotoxic terpenoids and flavonoids from Artemisia annua. PubMed: Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. PubMed: Anti-inflammatory activity and sub-acute toxicity of artemetin. PubMed: Chemical Constituents of Buxus sempervirens. PubMed: Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. PubMed: Isolation and identification of three new flavones from Achillea millefolium L.