acyclovir
2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
Identification
| Name | acyclovir |
| IUPAC | 2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one |
| CAS Number | 59277-89-3 |
| FDA UNII | X4HES1O11F |
| Molecular Formula | C8 H11 N5 O3 |
| Molecular Weight | 225.20827000 |
| MDL Number | MFCD00057880 |
| Nikkaji Number | J11.247J |
| Beilstein | 1219402 |
| XlogP3 | -1.60 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 255.00 °C. @ 760.00 mm Hg |
| Boiling Point | 594.97 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 7.500000 mmHg @ 25.00 °C. (est) |
| Flash Point | 597.00 °F. TCC ( 313.60 °C. ) (est) |
| logP (o/w) | -0.617 (est) |
| Soluble in | water, 3.399e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-child TDLo 3000 mg/kg/22W-I |
| Dermal Toxicity | subcutaneous-mouse LD50 1118 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for acyclovir usage levels up to | not for fragrance use. |
| Recommendation for acyclovir flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Glentham Life Sciences Ltd
The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
Potential Uses
Natural Occurrence
Synonyms
aciclovier
acyclo-V
alti-acyclovir
2-
amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one
2-
amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
2-
amino-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one
2-
amino-9-(2-hydroxy-ethoxymethyl)-1,9-dihydro-purin-6-one
2-
amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one
2-
amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one
2-
amino-9-[(2-hydroxyethoxy)methyl]-3,9-dihydro-6H-purin-6-one
2-
amino-9-{[(2-hydroxyethyl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
azone
cargosil
cyclovir
genvir
gerpevir
herpevir
9-[(2-
hydroxyethoxy)-methyl]guanine
9-((2-
hydroxyethoxy)methyl)guanine
9-[(2-
hydroxyethoxy)methyl]guanine
9-(2-
hydroxyethoxy)methylguanine
9-(2-
hydroxyethyloxymethyl)guanine
9-
hyroxyethoxymethylguanine
maynar
poviral
6H-
purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-
6H-
purin-6-one, 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-
vipral
viropump
virorax
viroraxl
zovir
zovirax
zyclir
PubMed:
Impact of hospital guideline for weight-based antimicrobial dosing in morbidly obese adults and comprehensive literature review.
PubMed:
Development of performance matrix for generic product equivalence of acyclovir topical creams.
PubMed:
Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients.
PubMed:
Comparison of in vitro release rates of acyclovir from cream formulations using vertical diffusion cells.
PubMed:
Electrosprayed core-shell solid dispersions of acyclovir fabricated using an epoxy-coated concentric spray head.
PubMed:
Inhibition of herpes simplex virus type 1 entry by chloride channel inhibitors tamoxifen and NPPB.
PubMed:
The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007.
PubMed:
The antiviral drug valacyclovir successfully suppresses salivary gland hypertrophy virus (SGHV) in laboratory colonies of Glossina pallidipes.
PubMed:
Biological activities of purified marennine, the blue pigment responsible for the greening of oysters.
PubMed:
Tsetse salivary gland hypertrophy virus: hope or hindrance for tsetse control?
PubMed:
Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry.
PubMed:
Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction.
PubMed:
The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo.
PubMed:
Analysis of the antiviral drugs acyclovir and valacyclovir-hydrochloride in tsetse flies (Glossina pallidipes) using LC-MSMS.
PubMed:
Valacyclovir: approved and off-label uses for the treatment of herpes virus infections in immunocompetent and immunocompromised adults.
PubMed:
Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets.
PubMed:
The treatment of herpes simplex infections: an evidence-based review.
PubMed:
Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP).
PubMed:
Radiesse-induced herpes zoster.
PubMed:
Antiviral activity of esterified alpha-lactalbumin and beta-lactoglobulin against herpes simplex virus type 1. Comparison with the effect of acyclovir and L-polylysines.
PubMed:
Bioavailability of two oral suspension and two oral tablet formulations of acyclovir 400 mg: two single-dose, open-label, randomized, two-period crossover comparisons in healthy Mexican adult subjects.
PubMed:
Chickenpox.
PubMed:
Genital herpes.
PubMed:
Topical Cidofovir for Treatment of Resistant Viral Infections.
PubMed:
Herpes labialis.
PubMed:
Developing an evidence-based, preventive care package for persons with HIV in Africa.
PubMed:
Exposure-response relationships and drug interactions of sirolimus.
PubMed:
Assessing bioequivalence using genomic data.
PubMed:
First one-day, oral antiviral for cold sores is approved.
PubMed:
Evaluation of USP apparatus 3 for dissolution testing of immediate-release products.
PubMed:
Pediatric uses of valacyclovir, penciclovir and famciclovir.
PubMed:
Comparison of new topical treatments for herpes labialis: efficacy of penciclovir cream, acyclovir cream, and n-docosanol cream against experimental cutaneous herpes simplex virus type 1 infection.
PubMed:
Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections.
PubMed:
Drug-resistant herpes: cidofovir gel in limbo. Interview with Jay Lalezari, M.D. Interview by John S. James.
PubMed:
[Primary varicella-zoster virus infection--current knowledge, diagnostic and therapeutic approaches].
PubMed:
Perspectives on switching oral acyclovir from prescription to over-the-counter status: report of a consensus panel.
PubMed:
Cidofovir use in acyclovir-resistant herpes infection.
PubMed:
Foscavir receives new indication.
PubMed:
New drug approvals in 1996.
PubMed:
The pharmacological profile of famciclovir.
PubMed:
Drug effective against herpes.
PubMed:
New drugs--reports of new drugs recently approved by the FDA. Valacyclovir.
PubMed:
Pharmacokinetics and tolerability of single oral doses of 882C87, a potent, new anti-varicella-zoster virus agent, in healthy volunteers.
PubMed:
Prevalence and patterns of use of concomitant medications among participants in three multicenter human immunodeficiency virus type I clinical trials. AIDS Clinical Trials Group (ACTG).
PubMed:
From the Food and Drug Administration.
PubMed:
Uses and safety of acyclovir in pregnancy.
PubMed:
Pregnancy outcomes following systemic prenatal acyclovir exposure--June 1, 1984-June 30, 1993.
PubMed:
Acyclovir (Zovirax) pharmacokinetics in Quaker parakeets, Myiopsitta monachus.
PubMed:
Clinical relevance of herpes simplex virus in the throat of elderly with Salmonella enteritidis gastroenteritis.
PubMed:
[Prevention against chickenpox in children is unnecessary!].
PubMed:
Acyclovir approved for childhood chickenpox.
PubMed:
From the Food and Drug Administration.
PubMed:
From the Food and Drug Administration.
PubMed:
[Prevention of bacterial infections after bone marrow graft by broad-spectrum oral antibiotics, absorbable (pefloxacin, penicillin) and non absorbable (cephalosporin, gentamycin, bacitracin)].
PubMed:
Open study of 2-amino-9-(hydroxyethoxymethyl)-9H-purine (desciclovir) in the treatment of herpes zoster.
PubMed:
Evaluation of drug reviews.
PubMed:
Oral form of acyclovir approved.
PubMed:
Mutagenicity in drug development: interpretation and significance of test results.
PubMed:
Acyclovir.
PubMed:
New anti-herpes virus drug being tested.