6H-3a,6-epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,5S,6S,8aS)-

CAS: 4871-97-0 C15 H24 O2 MW: 236.35468000

Identification

Namecurcumol
IUPAC(2S,5S,8S,9S)-9-isopropyl-2-methyl-6-methylene-11-oxatricyclo[6.2.1.01,5]undecan-8-ol
CAS Number4871-97-0
FDA UNII9190RTN07X
Molecular FormulaC15 H24 O2
Molecular Weight236.35468000
MDL NumberMFCD00272163

Regulatory

Physical Properties

Assay 80.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 332.00 to 334.00 °C. @ 760.00 mm Hg (est)
Flash Point 274.00 °F. TCC ( 134.70 °C. ) (est)
logP (o/w) 3.276 (est)
Soluble in water, 59.2 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for curcumol usage levels up tonot for fragrance use.
Recommendation for curcumol flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Potential Uses

None Found

Natural Occurrence

turmeric rhizome turmeric wild turmeric

Synonyms

6H-3a,6- epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethyl)-, (3S,5S,6S,8aS)- (3S-(3alpha,3aalpha,5alpha,6alpha,8abeta))- octahydro-3-methyl-8-methylene-5-(1-methyl ethyl)-6H-3a,6-epoxyazulen-6-ol (2S,5S,8S,9S)-9-iso propyl-2-methyl-6-methylene-11-oxatricyclo[6.2.1.01,5]undecan-8-ol PubMed: Analysis and pharmacokinetic study of curdione in Rhizoma Curcumae by UPLC/QTOF/MS. PubMed: Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model. PubMed: Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway. PubMed: Pharmacokinetics and liver distribution study of unbound curdione and curcumol in rats by microdialysis coupled with rapid resolution liquid chromatography (RRLC) and tandem mass spectrometry. PubMed: Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors. PubMed: Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264.7 cells. PubMed: Synthesis, anti-tumor activity, and structure-activity relationships of curcumol derivatives. PubMed: [Mechanism study on anti-proliferative effects of curcumol in human hepatocarcinoma HepG2 cells]. PubMed: Zedoary oil (Ezhu You) inhibits proliferation of AGS cells. PubMed: Modeling anti-allergic natural compounds by molecular topology. PubMed: [Effects end mechanisms of curcumol beta-cyclodextrin compound on the proliferation and apoptosls of esophageal carcinoma cell line TE-1]. PubMed: Microbial transformation of curcumol by Aspergillus niger. PubMed: [Effect and mechanism of curcumol on angiogenesis activity of zebrafishes]. PubMed: [Analysis of volatile compounds from Curcuma by microwave assisted solid phase headspace-gas chromatography]. PubMed: Subunit-specific inhibition of glycine receptors by curcumol. PubMed: Anti-cancer properties of terpenoids isolated from Rhizoma Curcumae--a review. PubMed: Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis. PubMed: [Effect of curcumol on proliferation and apoptosis of nasopharyngeal carcinoma cell line CNE-2]. PubMed: [Comparison of content of curdione, curcumol, germacrone and beta-elemene in different varieties of vinegar backed Rhizoma Curcuma]. PubMed: Isolation and identification of phase 1 metabolites of curcumol in rats. PubMed: [HPLC determination of six components in zedoary turmeric oil and its related injections]. PubMed: Preparative isolation and purification of six volatile compounds from essential oil of Curcuma wenyujin using high-performance centrifugal partition chromatography. PubMed: Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells. PubMed: Determination of curcumol in rat plasma by capillary gas chromatography with a hydrogen flame ionization detector. PubMed: Chemical constituents from the radix of Curcuma wenyujin. PubMed: Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. PubMed: A new eudesmane sesquiterpene lactone from Curcuma wenyujin. PubMed: [Determination of curcumol in plasma by HPLC-MS/MS method and its pharmacokinetics in Beagle dogs]. PubMed: Microbial transformation of curcumol by Cunninghamella blakesleana. PubMed: Four novel metabolites from microbial transformation of curcumol by Cunninghamella blakesleana. PubMed: [Study on the chemical constituents of Curcuma phaeocaulis]. PubMed: Simultaneous determination of 11 characteristic components in three species of Curcuma rhizomes using pressurized liquid extraction and high-performance liquid chromatography. PubMed: Optimization of GC-MS conditions based on resolution and stability of analytes for simultaneous determination of nine sesquiterpenoids in three species of Curcuma rhizomes. PubMed: [Determination of curcumol in Rhizoma Curcumae by GC]. PubMed: Fast determination of curcumol, curdione and germacrone in three species of Curcuma rhizomes by microwave-assisted extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry. PubMed: Seasonal variation and analgesic properties of different parts from Curcuma zedoaria Roscoe (Zingiberaceae) grown in Brazil. PubMed: [The fingerprint of Ezhu by GC-MS]. PubMed: Effects of different ingredients of zedoary on gene expression of HSC-T6 cells. PubMed: Molecular genetic and chemical assessment of Rhizoma Curcumae in China. PubMed: Identification and quantitation of eleven sesquiterpenes in three species of Curcuma rhizomes by pressurized liquid extraction and gas chromatography-mass spectrometry. PubMed: [Absorption of zedoary oil in rat intestine using in situ single pass perfusion model]. PubMed: A new triterpenoid from Entodon okamurae Broth. PubMed: [Studies on chemical constituents of Curcuma aromatica salisb]. PubMed: [Synthesis of 11-aminomethyl-2,6-dimethyl-3,9-diisopropyl-tricyclo [5.3.2.0(1.5)] dodeca-5,9-dien-8-ol]. PubMed: The absolute stereostructure of curcumol isolated from Curcuma wenyujin. PubMed: [The metabolism of 3H-curcumol in normal rats and tumour bearing mice (author's transl)]. PubMed: [The determination of curcumol in the volatile oil of Curcuma aromatica by phloroglucinol spectrophotometry (author's transl)]. PubMed: [Determination of curcumol in the volatile oil of Curcuma aromatica (author's transl)]. PubMed: Structure of curcumol. PubMed: Structure of curcumol.