butein

chalcone, 2',3,4,4'-tetrahydroxy- (2E)-1-(2,4- dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one (2E)-1-(2,4- dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one (E)-1-(2,4- dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one 2- propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-, (2E)- (E)-2',3,4,4'- terahydroxychalcone 2',3,4,4'- tetrahydroxychalcone PubMed: Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. PubMed: Inhibitory effects of butein on cancer metastasis and bioenergetic modulation. PubMed: [Chemical constituents from seeds of Sophora alopecuroides]. PubMed: Butein, a novel dual inhibitor of MET and EGFR, overcomes gefitinib-resistant lung cancer growth. PubMed: The depletion of securin enhances butein-induced apoptosis and tumor inhibition in human colorectal cancer. PubMed: Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species. PubMed: Inhibition of adipocyte inflammation and macrophage chemotaxis by butein. PubMed: Butein induces cell apoptosis and inhibition of cyclooxygenase‑2 expression in A549 lung cancer cells. PubMed: Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach. PubMed: Protective effect of detoxified Rhus verniciflua stokes on human keratinocytes and dermal fibroblasts against oxidative stress and identification of the bioactive phenolics. PubMed: Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway. PubMed: Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities. PubMed: Butein and its emerging anti-proliferative and pro-apoptotic effects in systemic malignancies. PubMed: Butein inhibits NF-κB activation and reduces infiltration of inflammatory cells and apoptosis after spinal cord injury in rats. PubMed: Butein is a novel anti-adipogenic compound. PubMed: Electrochemical oxidation of butein at glassy carbon electrodes. PubMed: Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions. PubMed: Butein imparts free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma. PubMed: Inhibitory effect of butein on tumor necrosis factor-α-induced expression of cell adhesion molecules in human lung epithelial cells via inhibition of reactive oxygen species generation, NF-κB activation and Akt phosphorylation. PubMed: Butein inhibits the proliferation of breast cancer cells through generation of reactive oxygen species and modulation of ERK and p38 activities. PubMed: Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress. PubMed: Natural chalcones as dual inhibitors of HDACs and NF-κB. PubMed: Antirestenosis effect of butein in the neointima formation progression. PubMed: Butein induces apoptosis in human uveal melanoma cells through mitochondrial apoptosis pathway. PubMed: Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography. PubMed: Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. PubMed: Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells. PubMed: Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells. PubMed: Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. PubMed: Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation. PubMed: Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo. PubMed: Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress. PubMed: Butein inhibits the migration and invasion of SK-HEP-1 human hepatocarcinoma cells through suppressing the ERK, JNK, p38, and uPA signaling multiple pathways. PubMed: A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). PubMed: Inhibitory effects of herbal alkaloids on the tumor necrosis factor-α and nitric oxide production in lipopolysaccharide-stimulated RAW264 macrophages. PubMed: HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos. PubMed: Butein from Rhus verniciflua protects pancreatic β cells against cytokine-induced toxicity mediated by inhibition of nitric oxide formation. PubMed: The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. PubMed: Butein, a tetrahydroxychalcone, suppresses cancer-induced osteoclastogenesis through inhibition of receptor activator of nuclear factor-kappaB ligand signaling. PubMed: Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo. PubMed: The potential influence of plant polyphenols on the aging process. PubMed: Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells. PubMed: Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. PubMed: Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells. PubMed: Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells. PubMed: Butein up-regulates the expression of the π class of glutathione S-transferase in rat primary hepatocytes through the ERK/AP-1 pathway. PubMed: Cloning, functional expression, and characterization of a chalcone 3-hydroxylase from Cosmos sulphureus. PubMed: Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular signal-regulated kinase/Sp1-dependent DR5 upregulation and NF-kappaB inactivation. PubMed: Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents. PubMed: Inhibitory effects of polyphenols isolated from Rhus verniciflua on Aldo-keto reductase family 1 B10. PubMed: Butrin, isobutrin, and butein from medicinal plant Butea monosperma selectively inhibit nuclear factor-kappaB in activated human mast cells: suppression of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8. PubMed: Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells. PubMed: [Chalcones from Bauhinia glauca subsp. pernervosa]. PubMed: [Studies on phenolic compounds from Sophora alopecuroides]. PubMed: Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. PubMed: Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. PubMed: Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes. PubMed: Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells. PubMed: Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles. PubMed: Bioactive flavonoids of the flowers of Butea monosperma. PubMed: Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. PubMed: Butein sensitizes human leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis inducing ligand (TRAIL). PubMed: Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. PubMed: A novel anticancer effect of butein: inhibition of invasion through the ERK1/2 and NF-kappa B signaling pathways in bladder cancer cells. PubMed: Antimicrobial and antioxidative activities of bioactive constituents from Hydnophytum formicarum Jack. PubMed: Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. PubMed: Structural requirements of 2',4',6'-tris(methoxymethoxy) chalcone derivatives for anti-inflammatory activity: the importance of a 2'-hydroxy moiety. PubMed: In vitro metabolism of isoliquiritigenin by human liver microsomes. PubMed: Butein blocks tumor necrosis factor alpha-induced interleukin 8 and matrix metalloproteinase 7 production by inhibiting p38 kinase and osteopontin mediated signaling events in HT-29 cells. PubMed: Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. PubMed: Butein suppresses bile acid-induced hepatocyte apoptosis through a JNK-dependent but ERK-independent pathway. PubMed: Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. PubMed: The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. PubMed: Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). PubMed: Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit. PubMed: Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. PubMed: 2',4',6'-Tris(methoxymethoxy) chalcone attenuates hepatic stellate cell proliferation by a heme oxygenase-dependent pathway. PubMed: Rhus verniciflua stokes extract: radical scavenging activities and protective effects on H2O2-induced cytotoxicity in macrophage RAW 264.7 cell lines. PubMed: Biocatalytic synthesis of butein and sulfuretin by Aspergillus alliaceus. PubMed: Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes. PubMed: Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. PubMed: Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose transport? PubMed: The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. PubMed: The chalcone butein from Rhus verniciflua Stokes inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. PubMed: Chalcones as potent tyrosinase inhibitors: the importance of a 2,4-substituted resorcinol moiety. PubMed: Facilitation of the purinergic contractile response of the guinea pig vas deferens by sodium orthovanadate. PubMed: Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by butein in RAW 264.7 cells. PubMed: Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. PubMed: Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. PubMed: Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers. PubMed: Relationship between flavonoid structure and inhibition of farnesyl protein transferase. PubMed: First bacterial chalcone isomerase isolated from Eubacterium ramulus. PubMed: Butein ameliorates renal concentrating ability in cisplatin-induced acute renal failure in rats. PubMed: Determination of butein in rat serum by high performance liquid chromatography. PubMed: The chalcone butein from Rhus verniciflua shows antifibrogenic activity. PubMed: Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. PubMed: Application of a molecularly imprinted polymer for the effective recognition of different anti-epidermal growth factor receptor inhibitors. PubMed: [Studies on flavonoid constituents of Caragana intermediia]. PubMed: Hypotensive effect of butein via the inhibition of angiotensin converting enzyme. PubMed: Selective separation of active inhibitors of epidermal growth factor receptor from Caragana jubata by molecularly imprinted solid-phase extraction. PubMed: Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. PubMed: Conjugation of chlorambucil with GSH by GST purified from human colon adenocarcinoma cells and its inhibition by plant polyphenols. PubMed: Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. PubMed: Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivatives. PubMed: Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. PubMed: Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. PubMed: Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. PubMed: Inhibitory activity of flavonoids and tannins against HIV-1 protease. PubMed: Antioxidant properties of butein isolated from Dalbergia odorifera. PubMed: Butein, a specific protein tyrosine kinase inhibitor. PubMed: Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera. PubMed: Inhibition of glutathione reductase by plant polyphenols. PubMed: Glutathione conjugation of chlorambucil: measurement and modulation by plant polyphenols. PubMed: Inhibition of various isoforms of rat liver glutathione S-transferases by tannic acid and butein. PubMed: Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimental anti-glomerular basement membrane antibody-associated glomerulonephritis (3). PubMed: Inhibition of the efflux of glutathione S-conjugates by plant polyphenols. PubMed: Butein ameliorates experimental anti-glomerular basement membrane (GBM) antibody-associated glomerulonephritis in rats (1). PubMed: Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor. PubMed: Variation in the modulation of superoxide-induced single-strand breaks in plasmid pBR322 DNA by biological antioxidants. PubMed: Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. PubMed: Inhibitory effects of plant polyphenols on rat liver glutathione S-transferases. PubMed: Protective effects of hydroxychalcones on free radical-induced cell damage. PubMed: Effects of gamma-linolenic acid, flavonoids, and vitamins on cytotoxicity and lipid peroxidation. PubMed: Studies on lipid oxidation in fish phospholipid liposomes. PubMed: Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes. PubMed: Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells. PubMed: Effect of myricetin and other flavonoids on the liver plasma membrane Ca2+ pump. Kinetics and structure-function relationships. PubMed: Phytoalexin synthesis in soybean cells: elicitor induction of reductase involved in biosynthesis of 6'-deoxychalcone. PubMed: Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects. PubMed: Metabolism and excretion of butein, 2',3,4-trihydroxychalcone, 3-O-methylbutein, 4-O-methylbutein and 2',4',4-trihydroxychalcone in the rat. PubMed: Condensed tannins. 10. Isolation of (--)-butin and butein from wattle heartwoods.