4-methoxychalcone

2-propen-1-one, 3-(4-methoxyphenyl)-1-phenyl- (9CI)

CAS: 959-33-1 C16 H14 O2 MW: 238.28598000

Identification

Name4-methoxychalcone
IUPAC3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
CAS Number959-33-1
EINECS213-499-7
FDA UNIISearch
Molecular FormulaC16 H14 O2
Molecular Weight238.28598000
MDL NumberMFCD00017179
XlogP33.10 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 397.30 °C. @ 760.00 mm Hg (est)
Flash Point 357.00 °F. TCC ( 180.40 °C. ) (est)
logP (o/w) 3.960 (est)
Soluble in water, 17.61 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for 4-methoxychalcone usage levels up tonot for fragrance use.
Recommendation for 4-methoxychalcone flavor usage levels up tonot for flavor use.

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

chalcone, 4-methoxy- (8CI) 4'- methoxybenzylidene acetophenone para- methoxyphenyl styryl ketone 3-(4- methoxyphenyl)-1-phenyl-2-propen-1-one 3-(4- methoxyphenyl)-1-phenylprop-2-en-1-one phenyl p-methoxystyryl ketone 2- propen-1-one, 3-(4-methoxyphenyl)-1-phenyl- (9CI) PubMed: Two new chalcones from Clerodendrum phlomidis. PubMed: In vitro action of flavonoids in the canine malignant histiocytic cell line DH82. PubMed: Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate. PubMed: 4-methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells. PubMed: Novel acetylated chalcone and biflavonoid glycosides from Trigonosciadium brachytaenium (Boiss.) Alava. PubMed: 4,2',5'-trihydroxy-4'-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages. PubMed: 2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells. PubMed: 2-hydroxy-4'-methoxychalcone inhibits proliferation and inflammation of human aortic smooth muscle cells by increasing the expression of peroxisome proliferator-activated receptor gamma. PubMed: Kinetic analysis of some chalcones and synthetic chalcone analogues on the fenton-reaction initiated deoxyribose degradation assay. PubMed: Two new chalcone glycosides from the stems of Entada phaseoloides. PubMed: PPARα activation by culinary herbs and spices. PubMed: Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells. PubMed: Leishmania amazonensis growth inhibitors: biological and theoretical features of sulfonamide 4-methoxychalcone derivatives. PubMed: Methoxy- and fluoro-chalcone derivatives arrest cell cycle progression and induce apoptosis in human melanoma cell A375. PubMed: Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone. PubMed: Flavonoids from the heartwood of Dalbergia odorifera and their protective effect on glutamate-induced oxidative injury in HT22 cells. PubMed: Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea. PubMed: Synthesis, biological evaluation and SAR of sulfonamide 4-methoxychalcone derivatives with potential antileishmanial activity. PubMed: Phytochemical investigation of Anaphalis lactea. PubMed: Allergy-preventive flavonoids from Xanthorrhoea hastilis. PubMed: Analysis of antioxidant activities contained in the Boesenbergia pandurata Schult. Rhizome. PubMed: Anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone. PubMed: A new chromone from Ficus lyrata. PubMed: Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by 2'-hydroxychalcone derivatives in RAW 264.7 cells. PubMed: Inclusion compounds of 2,5-diphenylhydroquinone. PubMed: Inhibition of prostalglandin E2 production by 2'-hydoxychalcone derivatives and the mechanism of action. PubMed: Androechin, a new chalcone glucoside from Andrographis echioides. PubMed: In vitro leishmanicidal activity of naturally occurring chalcones. PubMed: Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles. PubMed: Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis. PubMed: Chalcones, myo-inositol and other novel inhibitors of pulmonary carcinogenesis. PubMed: Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. PubMed: Introduction of unnatural amino acids into chalcone isomerase. PubMed: [Kinetics of the bacteriostatic activity of natural and synthetic chalcones on a strain of Staphylococcus aureus]. PubMed: Metabolism and excretion of butein, 2',3,4-trihydroxychalcone, 3-O-methylbutein, 4-O-methylbutein and 2',4',4-trihydroxychalcone in the rat.